Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Kunimoto, Mitsuhiro; Shimada, Kazunori; Yokoyama, M; Matsubara, Tomomi; Aikawa, Tatsuro; Ouchi, Shohei; Shimizu, Megumi; Fujita, Kosuke; Miyazaki, Tatsuya; Kadoguchi, Tomoyasu; Fujiwara, Kei; Abulimiti, Abidan; Honzawa, Akio; Yamada, Miki; Shimada, Akira; Yamamoto, Taira; Asai, Tomohiro; Amano, Atsushi; Smit, Andries J.; Daida, Hiroyuki

doi:10.1186/s12872-020-01484-3

Cited by 10 publications

(8 citation statements)

References 54 publications

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“…Additionally, a study on patients with HF with preserved ejection fraction found that higher SAF levels (SAF > 2.9 AU) were associated with first hospitalization for HF [ 32 ]. Moreover, our teams have recently reported that exercise capacity, a strong predictor in patients with CVD, was significantly lower in patients with higher SAF levels regardless of their DM status and that SAF levels were independently associated with exercise intolerance in patients with CVD [ 9 ]. The present study is the first to report that SAF levels are significantly associated with adverse outcomes in patients with HF who underwent CR.…”

Section: Discussionmentioning

confidence: 99%

“…Body composition, grip strength, and SAF level were assessed at the beginning of CR. Anthropometric parameters, including body fat percentage, lean body weight, and muscle mass, were measured by bioelectrical impedance analysis (TANITA, MC-780A, Tokyo, Japan), as previously described [ 9 ]. Grip strength test was conducted in both hands in a standing position; the higher grip strength value was used.…”

Section: Methodsmentioning

confidence: 99%

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Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation

Kunimoto

Yokoyama

Shimada

et al. 2021

Cardiovasc Diabetol

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Background Advanced glycation end-products, indicated by skin autofluorescence (SAF) levels, could be prognostic predictors of all-cause and cardiovascular mortality in patients with diabetes mellitus (DM) and renal disease. However, the clinical usefulness of SAF levels in patients with heart failure (HF) who underwent cardiac rehabilitation (CR) remains unclear. This study aimed to investigate the associations between SAF and MACE risk in patients with HF who underwent CR. Methods This study enrolled 204 consecutive patients with HF who had undergone CR at our university hospital between November 2015 and October 2017. Clinical characteristics and anthropometric data were collected at the beginning of CR. SAF levels were noninvasively measured with an autofluorescence reader. Major adverse cardiovascular event (MACE) was a composite of all-cause mortality and unplanned hospitalization for HF. Follow-up data concerning primary endpoints were collected until November 2017. Results Patients’ mean age was 68.1 years, and 61% were male. Patients were divided into two groups according to the median SAF levels (High and Low SAF groups). Patients in the High SAF group were significantly older, had a higher prevalence of chronic kidney disease, and more frequently had history of coronary artery bypass surgery; however, there were no significant between-group differences in sex, prevalence of DM, left ventricular ejection fraction, and physical function. During a mean follow-up period of 590 days, 18 patients had all-cause mortality and 36 were hospitalized for HF. Kaplan–Meier analysis showed that patients in the high SAF group had a higher incidence of MACE (log-rank P < 0.05). After adjusting for confounding factors, Cox regression multivariate analysis revealed that SAF levels were independently associated with the incidence of MACE (odds ratio, 1.86; 95% confidence interval, 1.08–3.12; P = 0.03). Conclusion SAF levels were significantly associated with the incidence of MACE in patients with HF and may be useful for risk stratification in patients with HF who underwent CR.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation

Kunimoto

Yokoyama

Shimada

et al. 2021

Cardiovasc Diabetol

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“…In contrast to our results, sAF proved to be an independent risk indicator for postoperative morbidity (OR = 2.8, p < 0.0001) and mortality (OR = 3.1, p < 0.0001) in that study. Two other studies showed in cardiac rehabilitation patients that sAF was independently associated with reduced exercise capacity [ 40 ] and in the case of patients with heart failures with new adverse cardiovascular events (MACE) [ 41 ]. Summarizing the available literature, it can be concluded that the noninvasive determination of sAF in cardiac surgery patients can be helpful in predicting cardiovascular outcome.…”

Section: Discussionmentioning

confidence: 99%

Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)

Reichert

Hofmann

Kohnert

et al. 2022

JCM

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Tissue concentrations of advanced glycation end product (AGE) and peripheral soluble receptor of AGE (sRAGE) levels may be associated with periodontitis severity. Both parameters and periodontitis might serve as outcome predictors for patients undergoing coronary artery bypass grafting (CABG). This study aimed to investigate possible associations between periodontitis and AGE/sRAGE. Ultimately, we wanted to examine whether AGE, sRAGE, and severe periodontitis are associated with the incidence of new cardiovascular events within 3 years of follow-up after CABG. Ninety-five patients with coronary vascular disease (CVD) (age 69 years, 88.3% males) needing CABG surgery were included. Periodontal diagnosis was made according to the guidelines of the “Centers for Disease Control and Prevention (CDC)” (2007) and staged according to the new classification of periodontal diseases (2018). AGE tissue concentrations were assessed as skin autofluorescence (sAF). sRAGE levels were determined by using a commercially available enzyme-linked immunoabsorbance assay (ELISA) kit. Univariate and multivariate baseline and survival analyses were carried out with Mann–Whitney U test, Chi² test, Kaplan–Meier curves with Log-Rank test, and logistic and Cox regression. sAF was identified as an independent risk indicator for severe periodontitis with respect to the cofactors age, gender, plaque index, and diabetes (adjusted odds ratio [OR] = 2.9, p = 0.028). The degree of subgingival inflammation assessed as a percentage of sites with bleeding on probing (BOP) was inversely correlated with sRAGE concentration (r = −0.189, p = 0.034). Both sAF (Hazard Ratio [HR] = 2.4, p = 0.004) and sRAGE (HR = 1.9, p = 0.031) increased the crude risk for new adverse events after CABG. The occurrence of severe periodontitis trends towards a higher risk for new cardiovascular events (HR = 1.8, p = 0.115). Applying multivariate Cox regression, only peripheral arterial disease (adjusted HR = 2.7, p = 0.006) and history of myocardial infarction (adjusted HR = 2.8, p = 0.010) proved to be independent risk factors for cardiovascular outcome. We conclude that sAF may represent a new, independent risk indicator for severe periodontitis. In contrast, sAF, sRAGE, and severe periodontitis were not independent prognostic factors for postoperative outcome in patients undergoing CABG.

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“…In addition, cohort studies of elderly people (≥ 65 years old) in Germany and Netherlands have found that blood and subcutaneous levels of AGEs were inversely associated with health-related quality of life (Drenth et al, 2018;Ebert et al, 2019). Negative correlations between blood CML level and walking speed and subcutaneous AGE level and maximal oxygen uptake have also been shown (Semba et al, 2010;Kunimoto et al, 2020). Collectively, the accumulation of AGEs in the body is a risk factor for decreased motor function.…”

Section: Glycative Stress and Motor Functionmentioning

confidence: 99%

Association of Glycative Stress With Motor and Muscle Function

Egawa

Hayashi

2022

Front. Physiol.

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Glycative stress is a type of biological stress caused by non-enzymatic glycation reactions, which include advanced glycation end product (AGE) formation, AGE accumulation, glycation-driven dysfunction of proteins and cellular signaling, inflammation, oxidation, and tissue damage. Increased glycative stress derived from hyperglycemia and lifestyle disorders is a risk factor in metabolic and age-related diseases, such as type 2 diabetes, cardiovascular disease, cancer, Alzheimer’s disease, osteoporosis, and dementia. Studies have shown that AGE accumulation is correlated with the age-related loss of muscle mass and power output, also called sarcopenia. Mechanistically, dysfunctions of contractile proteins, myogenic capacity, and protein turnover can cause glycative stress-induced skeletal muscle dysfunction. Because the skeletal muscle is the largest metabolic organ in the body, maintaining skeletal muscle health is essential for whole-body health. Increasing awareness and understanding of glycative stress in the skeletal muscle in this review will contribute to the maintenance of better skeletal muscle function.

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Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Cited by 10 publications

References 54 publications

Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation

Relationship between skin autofluorescence levels and clinical events in patients with heart failure undergoing cardiac rehabilitation

Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)

Association of Glycative Stress With Motor and Muscle Function

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