Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study

Xu, Lixia; Zeng, Zhirong; Chen, Bin; Wu, Xinxin; Yu, Jun; Xue, Ling; Tian, Linwei; Wang, Yiming; Chen, Minhu; Sung, Joseph J.Y.; Hu, Pinjin

doi:10.3892/ol.2011.249

Cited by 9 publications

(6 citation statements)

References 27 publications

(41 reference statements)

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“…Our results showed that subjects carrying the genotype TT in the locus − 509 of the TGF-β gene had a decreased risk for GC (Table 2). Our result is consistent with a recent meta-analysis, which also found that TT genotype at the locus − 509 of the TGF-β gene was protective for GC in an Asian population [21], as well as with other studies [22, 23]. In contrast, this TT genotype has been reported as a risk genotype for GC in an Indian and a Chinese population [24, 25].…”

Section: Discussionsupporting

confidence: 93%

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

et al. 2019

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Background Helicobacter pylori infection is recognized as the main risk factor for gastric cancer (GC), the fifth most common neoplasia worldwide. H. pylori interacts with the immune system, disrupting the cytokine network and inducing chronic inflammation. This work aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in selected cytokine gene promoters and GC. Methods The study included 359 subjects, 125 GC patients, 109 intestinal metaplasia (IM) patients and 125 asymptomatic controls. DNA was extracted from white blood cells and nine SNPs in cytokine gene promoters were genotyped using predesigned 5′-endonulease assays. The association of the SNPs with IM and GC was evaluated using multinomial regression models. Results Both genotypes, TC ( OR = 0.51, 95% CI = 0.27–0.98) and TT ( OR = 0.42, 95% CI = 0.20–0.91) in the locus − 509 of the TGF-β promoter were significantly associated with GC. The TT genotype in the locus − 819 of the IL-10 promoter was also significantly associated with GC ( OR = 0.37, 95% CI = 0.17–0.81). No significant association was found with SNPs IL-4 –590 T/C (rs1800629), IL-6 –573G/C (rs1800796), IL-10 –592C/A (rs1800872), IL-10 –1082A/G (rs1800896), and, IFN-γ –1615C/T (rs2069705). Conclusions SNPs in TGFβ (− 509 C/T, rs1800469) and IL-10 (− 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population.

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Section: Discussionsupporting

confidence: 93%

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

et al. 2019

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“…Most studies are about the mutations, variants, and polymorphisms of TGFB1 with gastric cancer. For example, the C-509T [ 38 ] and 509C/T [ 39 ] mutations were significantly associated with gastric cancer invasion. Therefore, in this study, by performing bioinformatics analysis, we showed that TGFB1 could also be considered as a diagnostic biomarker for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Important Molecular Pathways and Candidate Diagnostic Biomarkers of Noninvasive to Invasive Stages in Gastric Cancer by In Silico Analysis

Tutunchi

Akhavan

Bereimipour

et al. 2021

Journal of Oncology

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Gastric cancer affects millions of people each year; it is the fifth deadliest cancer globally. Due to failure to perform routine tests such as endoscopy, it is usually diagnosed in the invasive stages. Therefore, finding diagnostic biomarkers in blood can help to speed up the initial diagnosis of cancer. This study aimed to find appropriate diagnostic biomarkers in the extracellular matrix of noninvasive to invasive stages of gastric cancer patients, using bioinformatics analysis. First, we selected the appropriate datasets from the GEO database. We evaluated the genes’ signaling pathways, biological processes, and molecular functions. More accurately, we assessed the genes, in which their protein products are released into the extracellular matrix; we evaluated their protein network. Then, we validated the candidate proteins in the GEPIA and TCGA databases. The extracellular matrix, tyrosine kinase receptors, and immune response pathways are effective factors, which are related to the highly expressed genes and metabolism; cell cycle pathways are also impressive on low-expression genes. 69 highly expressed proteins are released into the extracellular matrix. After drawing the protein network, 5 proteins were selected as more suitable candidates for further studies. These proteins’ expression significantly increases in the human samples, and the survival chart showed up to about 80% mortality in the individuals over time. With integrated bioinformatics analysis, BGN, LOX, MMP-9, SERPINE1, and TGFB1 proteins have been selected as suitable diagnostic biomarkers for noninvasive to invasive stages of gastric cancer. Further studies are needed to evaluate more precise mechanisms between these proteins.

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“…Previously, we found decreased TGF-β1 in serum samples of male CRC patients significantly associated with CC genotype, indicating that -509C/T functional promoter polymorphism (rs1800469) within the TGF-β1 gene ( TGF-Β1 ) increased the cancer risk, particularly for advanced stages[ 14 ]. A noteworthy finding of the study of Xu et al [ 25 ] was that TGF-Β1 -509C/T and TGF-ΒR2 -875A/G gene polymorphisms acted synergistically on the decreased risk of gastric cancer. The risk of gastric cancer was notably lower among subjects who carried both the TGF-Β1 -509C and TGF-ΒR2 -875A allele genotypes.…”

Section: Discussionmentioning

confidence: 99%

Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

Stanilov

Grigorova

Velikova

et al. 2021

WJGO

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Association between the TGFB1 -509C/T and TGFBR2 -875A/G polymorphisms and gastric cancer: a case-control study

Cited by 9 publications

References 27 publications

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Evaluation of Important Molecular Pathways and Candidate Diagnostic Biomarkers of Noninvasive to Invasive Stages in Gastric Cancer by In Silico Analysis

Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

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