Association between the PlA platelet glycoprotein GPIIIa polymorphism and extent of coronary artery disease

Gruchała, Marcin; Ciećwierz, Dariusz; Ochman, Karolina; Targoński, Radosław; Dubaniewicz, Witold; Sobiczewski, Wojciech; Wasąg, Bartosz; Drewla, Piotr; Skarżyński, Paweł; Romanowski, Piotr; Limon, Janusz; Rynkiewicz, Andrzej

doi:10.1016/s0167-5273(02)00412-6

Cited by 12 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of the association between carriage of the PlA2 allele and MI using data adjusted for age, sex, ethnicity and cardiovascular risk factors demonstrated an increased level of association ( n = 12,001; OR 1.240, 95% CI 1.117–1.376; p<0.001) [87], [88], [96], [97], [101], [109], [110], [112], [119]–[121], [125], [127]. Further subgroup analysis based on comparison of the PlA1/A1 versus PlA2/A2 genotype failed to show a significant association ( n = 23,836; OR 1.023, 95% CI 0.877–1.192; p = 0.774) [70]–[72], [81], [82], [86]–[91], [95], [98]–[100], [102]–[104], [106]–[108], [111]–[114], [116], [117], [120], [122], [124], [128] (Figure 3); however, within this analysis, the number of subjects with the PlA2/A2 genotype was small, consisting of 333 cases and 1,504 controls.…”

Section: Resultsmentioning

confidence: 99%

“…Analysis based on ethnicity was limited to Caucasians as the majority of studies did not explicitly state the ethnicity of participants. A non-significant pooled OR for the association of PlA2 carriage with MI was observed for the 11 available studies ( n = 10,585; OR 1.050, 95% CI 0.962–1.146; p = 0.272) [71], [81], [88], [95]–[97], [103], [109], [112], [127], [128].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

View full text Add to dashboard Cite

BackgroundThe PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI.MethodsElectronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated using fixed-effects and random-effects models. The primary outcome measure was MI, and a secondary analysis was also performed for acute coronary syndromes (ACS) more generally.Findings57 studies were eligible for statistical analysis and included 17,911 cases and 24,584 controls. Carriage of the PlA2 allele was significantly associated with MI (n = 40,692; OR 1.077, 95% CI 1.024–1.132; p = 0.004) but with significant publication bias (p = 0.040). The degree of association with MI increased with decreasing age of subjects (≤45 years old: n = 9,547; OR 1.205, 95% CI 1.067–1.360; p = 0.003) and with adjustment of data for conventional cardiovascular risk factors (n = 12,001; OR 1.240, 95% CI 1.117–1.376; p<0.001). There was a low probability of publication bias for these subgroup analyses (all p<0.05).ConclusionsThe presence of significant publication bias makes it unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The PlA1/A2 Polymorphism of Glycoprotein IIIa as a Risk Factor for Myocardial Infarction: A Meta-Analysis

2014

View full text Add to dashboard Cite

show abstract

“…We believe that the study by Gruchala et al [1] gives an excellent example on the fact that the association of genetic factors with coronary disease is highly dependent on the clinical phenotype studied. Although the endpoints may be similar, the risk factors and pathogenesis of coronary disease have enormous interindividual variety ranging from an isolated event of coronary thrombosis and myocardial infarction with normal coronary arteries to an extensively diseased coronary artery tree.…”

mentioning

confidence: 92%

“…In their recent study, Gruchala et al [1] reported an association of the platelet GPIIIa Pl A polymorphism A1/A1 genotype with increased severity of coronary artery disease as opposed to A2 carriers of the GPIIIa polymorphism. In their discussion, they highlighted their study as the first one to report such an association.…”

mentioning

confidence: 99%

The platelet GPIIIa PlA polymorphism and the extent of coronary disease—a reply

Mikkelsson

Karhunen

2005

International Journal of Cardiology

View full text Add to dashboard Cite

“…We thank Dr. Mikkelsson and Dr. Karhunen for their comments on our recent article [1]. The letter addresses very important issues regarding the complexity of genetic association studies in coronary artery disease.…”

mentioning

confidence: 99%