Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review

Xiang, Tong; Wan, Qunfang; Li, Zhenzhen; Liu, Sitong; Huang, Jiao; Wu, Man; Fan, Hong

doi:10.1016/j.micpath.2019.04.023

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…The analysis did not differentiate between the total sample and PTB subgroups. Tong et al suggested that rs1800450 and rs5030737 polymorphisms were risk factors for susceptibility to TB; nevertheless, rs7095891 and rs1800451 polymorphisms acted as protective factors against TB [57]. Their study did not analyze the differences between the total sample and subgroups of TB.…”

Section: Discussionmentioning

confidence: 96%

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Shen

Yang

et al. 2020

Hereditas

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Background: Mannose-binding lectin (MBL2) is considered to play a role in the human innate immune response to tuberculosis (TB) infections, and 4 common single nucleotide polymorphisms (SNPs) may be associated with pulmonary tuberculosis (PTB) risk. To examine these potential associations, we performed a comprehensive analysis to assess the relationships between MBL2 polymorphisms and PTB. Methods: The PubMed, Embase, and SinoMed databases were searched for articles published prior to June 13, 2019. Odds ratios with 95% confidence intervals were calculated to evaluate the strength of the relationships. Results: There were 37 case-control studies examining the effects of the four SNPs in MBL2 on PTB. A positive association between rs11003125 and PTB risk was observed in the hospital-based subgroup. Moreover, for the combined polymorphism and PTB risk, positive associations were detected not only in the total population but also in those with Asian origins across all source of control subgroups. No associations were found for rs7096206 or rs7095891. Conclusions: Our current study indicated that several SNPs in MBL2 may be associated with susceptibility to PTB.

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Section: Discussionmentioning

confidence: 96%

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Shen

Yang

et al. 2020

Hereditas

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“…To our knowledge, this is the first study to report that the rs930507, rs2099902, and rs10824793 polymorphisms can affect TB development in a population of Han Chinese origin. It is worth mentioning that several meta-analysis studies have reported that five MBL2 SNPs (rs1800450, rs1800451, rs5030737, rs7095891, and rs7096206) are associated with an increased or decreased TB risk [22][23][24][25][26]. However, there is insufficient data regarding the role of rs930507, rs2099902, and rs10824793 in TB susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population

et al. 2020

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Background: Immune-and inflammation-related genes (IIRGs) play an important role in the pathogenesis of tuberculosis (TB). However, the relationship between IIRG polymorphisms and TB risk remains unknown. In this study, the gene polymorphisms and their association with tuberculosis were determined in a Chinese population. Methods: We performed a case-control study involving 1016 patients with TB and 507 healthy controls of Han Chinese origin. Sixty-four single-nucleotide polymorphisms (SNPs) belonging to 18 IIRGs were genotyped by the PCR-MassArray assay, and the obtained data was analyzed with χ 2-test, Bonferroni correction, and unconditional logistic regression analysis. Results: We observed significant differences in the allele frequency of LTA rs2229094*C (P = 0.015), MBL2 rs2099902*C (P = 0.001), MBL2 rs930507*G (P = 0.004), MBL2 rs10824793*G (P = 0.004), and IL12RB1 rs2305740*G (P = 0.040) between the TB and healthy groups. Increased TB risk was identified in the rs930507 G/G genotype (P adjusted = 0.027) under a codominant genetic model as well as in the rs2099902

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“…It has been suggested that, at the population level, the clinical consequences of an inherently high ability to produce functionally active MBL in the Arctic representatives are low risk of severe bacterial infections at early age and, likely the higher risk of tuberculosis at older age, [18,26]. Moreover, the low incidence of atherosclerosis and cardio-vascular diseases among the aborigines of the Arctic, along with factors such as high consumption of omega-3 fatty acids and lifestyle features, might be due to the genetic characteristics of the production and activity of MBL.…”

Section: Discussionmentioning

confidence: 99%

“…The recent meta-analyses have shown that the relationship between MBL genotypes and tuberculosis are controversial, i.e. some genetic variations increase the risk of the disease (rs1800450, rs5030737), while some may decrease (rs1800451, rs7095891), [24][25][26]. The analysis is complicated by large heterogeneity in different clinical forms of tuberculosis in the studies.…”

Section: Introductionmentioning

confidence: 99%

Mannose-binding lectin gene polymorphisms in the East Siberia and Russian Arctic populations

Tereshchenko

Смольникова

Фрейдин

2020

Preprint

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Background: Mannose-binding lectin (MBL) encoded by MBL2 gene is a protein with the ability to form carbohydrate complexes with microbial wall promoting their subsequent elimination.Genetically determined levels of MBL can modify the risk and clinical characteristics of many infectious diseases. The frequency of MBL2 genotypes exhibits significant population differences.The data on the distribution of MBL2 genotypes among the aborigines of the Russian Arctic territories have not yet been published. Methods:A total of 880 specimens of dried blood spots of the newborns were genotyped. The newborns represented four populations: Nenets, Dolgan-Nganasans, Mixed aboriginal population, and Russians (Caucasians, Krasnoyarsk). Six polymorphisms of the MBL2 gene were studied: rs11003125, rs7096206, rs7095891, rs5030737, rs1800450, and rs1800451. Results:The frequency of the combined rare O allele (composed of the coding region variants rs5030737, rs1800450, and rs1800451) in the homozygous state was significantly higher in Russians: 10% vs 2% in Nenets and 1% in Dolgan-Nganosans (p<0.001 for Russians vs other populations). The frequency of the high-producing haplotype (HYPA) was 35.4% in the Russian newborns, in keeping with European populations (27-33%); 64% for Nenets and 56% for Dolgan-Nganasans, similar to the estimates obtained for Eskimos and North Amerinds (64-81%). Conclusion:Our study results are in line with the hypothesis that human evolution has been moving in the direction of accumulation of the genotypes associated with low activity of the lectin complement activation pathway because of the prevalence of some intracellular infections such as tuberculosis, whereby low MBL activity may have a protective effect.

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Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review

Cited by 17 publications

References 39 publications

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Association between polymorphisms in mannose-binding lectin 2 gene with pulmonary tuberculosis susceptibility

Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population

Mannose-binding lectin gene polymorphisms in the East Siberia and Russian Arctic populations

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