Association between the malnutrition-inflammation score and post-transplant anaemia

Molnar, Miklos Z.; Czira, Maria E.; Rudas, Anna; Újszászi, Ákos; Haromszeki, Bela; Kósa, János P.; Lakatos, Péter; Bekő, Gabriella; Sárváry, Enikő; Varga, Marina; Fornadi, Katalin; Novák, Márta; Rosivall, László; Kiss, István; Remport, Ádám; Goldsmith, David; Kövesdy, Csaba P.; Mucsi, István

doi:10.1093/ndt/gfq690

Cited by 51 publications

(38 citation statements)

References 40 publications

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“…Thus, it is important to integrate information from multiple biomarkers to describe the prevailing inflammatory state (18)(19)(20). We computed an inflammation score after integrating the data from all measured proinflammatory markers and found that the intensity of inflammation was positively related to the level of UACR and inversely related to eGFR (Figures 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

“…An inflammation score has been shown to more accurately predict the phenotype of interest than a single biomarker of inflammation (18)(19)(20). In these studies, inflammation was determined to be present in a particular participant if serum level of an inflammatory biomarker exceeded its median value for the whole cohort.…”

Section: Calculation Of Inflammation Scorementioning

confidence: 99%

See 1 more Smart Citation

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

Gupta

Mitra

Kanetsky

et al. 2012

Clinical Journal of the American Society of Nephrology

449

344

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Section: Discussionmentioning

confidence: 99%

Section: Calculation Of Inflammation Scorementioning

confidence: 99%

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

Gupta

Mitra

Kanetsky

et al. 2012

Clinical Journal of the American Society of Nephrology

449

344

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“…The creation of the cohort has been described previously. [28][29][30][31][32][33][34] From these 150 eligible patients, 100 individuals agreed to participate and they underwent 1-night PSG (kTx participant sample). From this sample of 100 patients, 3 were excluded from our analysis because of a missing depression score and 2 were excluded because of antidepressant pharmacotherapy.…”

Section: Sample Of Patients and Data Collectionmentioning

confidence: 99%

“…[28][29][30][31][32][33][34] Potentially eligible patients were selected from all prevalent adult kTx recipients (total clinic population; n = 1,214) who were regularly followed at a single outpatient academic transplant center, the kidney transplant clinic of the Department of Transplantation and Surgery at the Semmelweis University, Budapest, Hungary (Figure 1). All patients followed at the clinic on December 31, 2006 were considered for enrollment in the Malnutrition and INflammation In Transplant (MINIT-HU) study.…”

Section: Sample Of Patients and Data Collectionmentioning

confidence: 99%

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Rónai

Szentkirályi

Lázár

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. Methods: Ninety-five kTx recipients participated in the study (54 males, mean ± standard devation age 51 ± 13 years, body mass index 26 ± 4 kg/m 2 , estimated glomerular filtration rate 53 ± 19 ml/min/1.73 m 2 ). Symptoms of depression were assessed by the Center for Epidemiologic Studies -Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. Results: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = −0.24, P < .05), but not with the amount of slow wave sleep (r = −0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (β: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (β: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. I NTRO DUCTI O NDepression is one of the most prevalent mental health conditions in patients with chronic kidney disease (CKD) [1][2][3][4] ; furthermore, it is an important determinant of impaired quality of life. 5,6 Among kidney transplant (kTx) recipients, depression is associated with reduced adherence and also with increased morbidity, graft loss, and mortality. [7][8][9][10][11][12][13] Poor sleep and various sleep problems are also frequent complaints among kTx recipients.14,15 Earlier we reported that chronic insomnia was independently associated with the presence of depression in kTx recipients. 16 In the general population there is a strong and bidirectional relationship between depression and sleep.17 This is also reflected in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition definition of major depression (MD), 18 as sleep complaints are core symptoms of MD. Several objective sleep parameters are different in patients with MD than in healthy control patients. Patients with MD have decreased amounts of slow wave sleep (SWS) and shortened rapid eye movement (REM) latency with increased amounts of REM sleep. The exact mechanisms and factors that may link depression to poor clinical outcomes among kTx recipients are not yet well defined. In a recent review focusing on kTx and depression, 23 sleep is not mentioned. This may be due to the complete lack of polysomnography (PSG) studies that assess the association between sleep and depression in this population. The frequent co-occurrence of subjective sleep complaints and depression among kTx recipients 16 suggests that the relationship between the two conditions may be similar to the association described in the g...

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“…Oterdoom et al found that higher muscle mass, assessed by 24-hour urine creatinine excretion, is associated with better survival after kidney transplantation (42). In dialysis patients low serum creatinine is a marker for protein-energy wasting (43), which is a strong predictor of mortality (44,45) and anemia (46) in renal transplant recipients. To the best of our knowledge, no prior study has examined the effect of pretransplant serum creatinine in MHD patients on outcomes after kidney transplantation.…”

Section: ͻ0001mentioning

confidence: 99%

Associations of Pretransplant Weight and Muscle Mass with Mortality in Renal Transplant Recipients

Streja¹,

Molnar²,

Kövesdy³

et al. 2011

Clinical Journal of the American Society of Nephrology

157

148

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Summary Background and objectives:The association between pretransplant body composition and posttransplant outcomes in renal transplant recipients is unclear. It was hypothesized that in hemodialysis patients higher muscle mass (represented by higher pretransplant serum creatinine level) and larger body size (represented by higher pretransplant body mass index [BMI]) are associated with better posttransplant outcomes. Design, setting, participants, & measurements:Linking 5-year patient data of a large dialysis organization (DaVita) to the Scientific Registry of Transplant Recipients, 10,090 hemodialysis patients were identified who underwent kidney transplantation from July 2001 to June 2007. Cox regression hazard ratios and 95% confidence intervals of death and/or graft failure were estimated. Results:Patients were 49 Ϯ 13 years old and included 49% women, 45% diabetics, and 27% African Americans. In Cox models adjusted for case-mix, nutrition-inflammation complex, and transplant-related covariates, the 3-month-averaged postdialysis weight-based pretransplant BMI of 20 to Ͻ22 and Ͻ 20 kg/m 2 , compared with 22 to Ͻ25 kg/m 2 , showed a nonsignificant trend toward higher combined posttransplant mortality or graft failure, and even weaker associations existed for BMI Ն 25 kg/m 2 . Compared with pretransplant 3-month-averaged serum creatinine of 8 to Ͻ10 mg/dl, there was 2.2-fold higher risk of combined death or graft failure with serum creatinine Ͻ4 mg/dl, whereas creatinine Ն14 mg/dl exhibited 22% better graft and patient survival. Conclusions:Pretransplant obesity does not appear to be associated with poor posttransplant outcomes. Larger pretransplant muscle mass, reflected by higher pretransplant serum creatinine level, is associated with greater posttransplant graft and patient survival.

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Association between the malnutrition-inflammation score and post-transplant anaemia

Abstract: The MIS is independently associated with PTA in the kidney-transplanted population with eGFR lower than or equal to 60 mL/min/1.73 m(2).

Cited by 51 publications

References 40 publications

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

Depressive Symptoms Are Associated With Objectively Measured Sleep Parameters in Kidney Transplant Recipients

Associations of Pretransplant Weight and Muscle Mass with Mortality in Renal Transplant Recipients

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