Association Between the hsa-mir-27a Variant and Breast Cancer Risk: a Meta-analysis

Association of a Pre-miR-27a Polymorphism with Cancer Risk: an Updated Meta-analysis

“…Previous meta-analysis by Wang et al showed that significantly increased cancer risks were associated with rs895819 AG polymorphism heterozygote and dominant model in Asian based on two studies (549 cases and 547 controls) (Wang et al, 2012). By including one (Zhong et al, 2013), or two more studies , however, the later pooled analyses did not find this association in Asian.…”

“…Out of the Twenty-five, seven articles were pooled analysis, commentary and review papers (Wang et al, 2012;Yang and Burwinkel, 2012;Ma et al, 2013;Wang et al, 2013;Xu et al, 2013b;Zhong et al, 2013;Chen et al, 2014), and four reports were cancer biology experimental studies (Hirota et al, 2012;Jahid et al, 2012;Zanetti et al, 2012;Yuan et al, 2013). Three studies were excluded given that they did not include controls (Yoon et al, 2012;Xu et al, 2013a), or reported non-cancer disease (Song et al, 2013).…”

“…Some other epidemiological studies have examined the association between rs895819 and cancer risk in other type of cancers, but showed an inconsistent conclusion (Sun et al, 2010;Hezova et al, 2012;Shi et al, 2012;Zhou et al, 2012). Meta-analysis studies revealed that rs895819 was a functional SNP and may have some relation to breast cancer susceptibility, or cancer development in Caucasian (Wang et al, 2012;Wang et al, 2013;Xu et al, 2013b;Zhong et al, 2013). Due to limited studies and data presented in original reports, however, these meta-analysis studies did not calculate the pooled odd ratio (OR) for different subgroups of breast cancers or other types of cancers.…”

Association Between the Pre-mir-218 Polymorphism and Cancer Risk in the Chinese Population: a Meta-Analysis

“…The link between genetic variants in miRNAs and cancer was highlighted by many researchers. Wang et al (2012) found that hsamir-27a rs895819 may play an important role in breast cancer development. Zhang et al (2013) reported the association of mir-499 rs3746444 polymorphism and mir-149 rs2292832 polymorphism with cancer risk in the Chinese population and found that rs3746444 GG genotype is associated with increased cancer risk, especially liver cancer, while the rs2292832 polymorphism showed no association with cancer risk in Chinese.…”

In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/β-catenin signaling pathway

“…Currently, for a vast majority of BC patients, mastectomy coupled with radiotherapy is widely put into practice for treatment with a relatively effective result [3]. However approximately10% of women diagnosed with BC exhibited a family history, so further studies concerning BC related genetic variants are necessary [4]. Wacholder et al revealed that multiple genetic variants were associated with this type of cancer [5].…”