Association Between the Pre-mir-218 Polymorphism and Cancer Risk in the Chinese Population: a Meta-Analysis

Gao, Yue; Liu, Yan; Liu, Geli; Ran, Longke; Zeng, Fan; Wu, Jiayan; Song, Fangzhou

doi:10.7314/apjcp.2014.15.6.2517

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…A meta-analysis showed that rs11134527 polymorphism was associated with risk of cervical cancer but not hepatocellular carcinoma [24] In the present study, no association was observed between rs11134527 and GC risk in all of the four genetic models (dominant model, recessive model, codominant model, and overdominant model). Jiang et al found that the G/G genotype of rs11134527 was significantly associated with a better prognosis of esophageal squamous cell carcinoma in a codominant model [25].…”

Section: Discussioncontrasting

confidence: 58%

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Jia

Cao

et al. 2017

Disease Markers

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Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93, P = 0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95, P = 0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

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Section: Discussioncontrasting

confidence: 58%

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Jia

Cao

et al. 2017

Disease Markers

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“…MiR-218 is a tumor suppressor gene that is expressed at significantly low levels in various tumors. Some targets of miR-218 , such as ROBO1, RICTOR, BIRC5 and LAMB3 , have been reported to participate in many cancer signaling pathways, such as the ERK/MAPK, Wnt/β-catenin , and Notch pathways [ 12 , 41 , 42 ]. These findings indicate that the up-regulation of miR-218 may reduce the risk of cancer by down-regulating these targets.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have revealed the relationship between the miR-218 polymorphism and cancer risk in the Chinese population. Gao et al [ 12 ] reported a meta-analysis about cancer in the Chinese population, and their results revealed that the miR-218 rs11134527 A>G polymorphism is linked to a remarkable reduction in cancer risk in GG genotype people compared with AA and AG genotype people. Other studies have demonstrated that the miR-218 rs11134527 A>G polymorphism is related to the susceptibility to cervical cancer, esophageal squamous cell carcinoma, breast cancer, and neuroblastoma [ 13–16 ].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between miR-218 rs11134527 A>G and Kawasaki disease susceptibility

et al. 2018

Bioscience Reports

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Kawasaki disease (KD) is a type of disease that includes the development of a fever that lasts at least 5 days and involves the clinical manifestation of multicellular vasculitis. KD has become one of the most common pediatric cardiovascular diseases. Previous studies have reported that miR-218 rs11134527 A>G is associated with susceptibility to various cancer risks. However, there is a lack of evidence regarding the relationship between this polymorphism and KD risk. The present study explored the correlation between the miR-218 rs11134527 A>G polymorphism and the risk of KD. We recruited 532 patients with KD and 623 controls to genotype the miR-218 rs11134527 A>G polymorphism with a TaqMan allelic discrimination assay. Our results illustrated that the miR-218 rs11134527 A>G polymorphism was not associated with KD risk. In an analysis stratified by age, sex, and coronary artery lesions, we found only that the risk of KD was significantly decreased for children older than 5 years (GG vs. AA/AG: adjusted OR = 0.26, 95% CI = 0.07–0.94, P=0.041). The present study demonstrated that the miR-218 rs1113452 A>G polymorphism may have an age-related relationship with KD susceptibility that has not previously been revealed.

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“…Single nucleotide polymorphisms (SNPs), the most common genetic variation, have been demonstrated to influence the expression or target site selection of miRNAs and thus are involved in a series of biological processes by interfering interaction between miRNAs and target mRNAs [8, 9]. SNPs present in the miRNA genes have been illustrated to be a potentially important mechanism in the development and progression of cancer [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects

et al. 2016

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Single nucleotide polymorphisms (SNPs) in MicroRNAs (miRNAs) are involved in the mechanism of carcinogenesis. Several studies have evaluated the association of rs4919510 SNP in miR-608 with cancer susceptibility in different types of cancer, with inconclusive outcomes. To obtain a more precise estimation, we carried out this meta-analysis through systematic retrieval from the PubMed and Embase database. A total of 10 case-control studies were analyzed with 6,000 cases and 7,664 controls. The results showed that 4919510 SNP in miR-608 was significantly associated with decreased cancer risk only in recessive model (CC vs. GG+GC: OR=0.89, 95% CI: 0.82-0.97, P=0.009). By further stratified analysis, we found that rs4919510 SNP had some relationship with decreased cancer risk in both homozygote model (CC vs. GG: OR=0.59, 95% CI: 0.36-0.96, P=0.034) and dominant model (CG+ CC vs. GG: OR=0.60, 95% CI: 0.37-0.98, P=0.042) in Caucasians but no relationship in any genetic model in Asians. These results indicated that miR-608 rs4919510 polymorphism may contribute to the decreased cancer susceptibility and could be a promising target to forecast cancer risk for clinical practice. However, to further confirm these results, well-designed large scale case–control studies are needed in the future.

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Association Between the Pre-mir-218 Polymorphism and Cancer Risk in the Chinese Population: a Meta-Analysis

Cited by 6 publications

References 27 publications

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Lack of association between miR-218 rs11134527 A>G and Kawasaki disease susceptibility

Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects

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Association Between the Pre-mir-218 Polymorphism and Cancer Risk in the Chinese Population: a Meta-Analysis

Cited by 6 publications

References 27 publications

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Lack of association between miR-218 rs11134527 A&gt;G and Kawasaki disease susceptibility

Association of miR-608 rs4919510 polymorphism and cancer risk: a meta-analysis based on 13,664 subjects

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Product

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Lack of association between miR-218 rs11134527 A>G and Kawasaki disease susceptibility