Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis

Zhao, Ge; Cai, Yunfei; Liu, Jing; Meng, Ting

doi:10.1042/bsr20181548

Cited by 10 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previously, loci rs2234693 and rs9340799 associated with IUGR were also reported as candidate for preeclampsia [28][29][30], age of menarche [31], precocious puberty [32], height at menarche [33], premature ovarian failure [34], endometriosis [35], breast cancer [36], type II diabetes mellitus [37]. Specifically, Molvarec [28] reported the GG genotype of the rs9340799 was associated with a lower risk of IUGR in patients with severe preeclampsia while the homozygous TA haplotype carriers of ESR1 rs2234693 and rs9340799 polymorphisms showed an increased risk of severe preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of Central Russia

Golovchenko

Abramova

Ponomarenko

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

This study aimed to investigate the role ofESR1 and PGR gene polymorphisms in development of intrauterine growth restriction (IUGR) among Russian women in Central Russia.Study design: This case-control study recruited a total of 520 women in the third trimester of pregnancy, including 196 IUGR patients and 324 controls. The participants were unrelated women of self-reported Russian ethnicity. Participants were genotyped at 4 functionally significant polymorphisms of theESR1 (rs2234693, rs9340799) and the PGR (rs484389, rs1042838) genes. The association analysis was performed using logistic regression. Two polymorphisms, which were associated with IUGR, and 26 polymorphisms linked to them (r 2 !0.6) were analyzed for their functional significance in silico. Results: Haplotype TG of loci rs2234693-rs9340799ESR1 (OR = 1.94, p perm = 0.006) was associated with an increased risk of IUGR. Allele T of rs2234693 decreases expression of ESR1 in thyroid gland, allele T of rs2234693 and allele G of rs9340799 increase affinity to eight transcription factors (AP-4, HEN1, E2A, LBP-1, RP58, LUN, Ets and Hand). The loci that are linked (r 2 !0.6) to the IUGR-associated SNPs, have the cis-eQTL value (expression ESR1 in thyroid gland) and showed their regulatory effects in organs and tissues related to pathogenesis of IUGR. Conclusion:Haplotype TG defined by polymorphisms rs2234693-rs9340799 of theESR1 gene is associated with the development of IUGR in Russian women from Central Russia.

show abstract

Section: Discussionmentioning

confidence: 99%

Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of Central Russia

Golovchenko

Abramova

Ponomarenko

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

show abstract

“…Although the etiology of PE is considered to be multifactorial, genetic factors are thought to be strong determinants of this disease [4,6]. Early studies reported that VEGF genes were associated with vascular growth and endothelial dysfunction, which may somewhat interpret the development of PE.…”

Section: Discussionmentioning

confidence: 99%

“…Although its etiology has not been well recognized, PE is now regarded as the result of the combined effect of multiple factors [4,5]. According to the results of the several epidemiological studies, PE has a substantial heritable component, which is estimated to be a major effect [4,6].…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

et al. 2020

View full text Add to dashboard Cite

Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension disease. Some case–control studies reported the association between vascular endothelial growth factor (VEGF) gene polymorphisms (rs3025039, rs2010963) and PE risk. However, these associations were inconsistent in several studies. Therefore, we conducted this meta-analysis to assess the role of VEGF gene polymorphisms in PE more precisely. Methods: Eligible studies were searched in PubMed, Embase, Web of Science and Chinese (Chinese National Knowledge Infrastructure (CNKI) and WanFang) databases. Statistical analyses were performed by Stata 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. In addition, subgroup analyses, sensitive analyses and publication bias analyses were performed to further assess this meta-analysis. Results: In total, 21 studies were included in the meta-analysis covering 2018 cases and 2632 controls. There were significant associations between VEGF polymorphisms (rs3025039, rs2010963) and PE risk in the overall populations. In the subgroup analyses, we found that rs3025039 polymorphism was associated with the increased risk of PE among Chinese. As for rs2010963 polymorphism, a significant association was observed in subgroup of Caucasian. Conclusion: The present study suggested that the two VEGF gene polymorphisms (rs3025039, rs2010963) are associated with increased risk of PE in different ethnic groups, which means that the targets may be useful genetic markers for early prediction of PE.

show abstract

“…This meta-analysis indicated that the PvuII and XbaI polymorphisms were not associated with the risk of endometriosis [23]. Results of meta-analysis which studied the relation between ESR1 gene polymorphism (-351A/G and -397T/C variants) demonstrated the increased risk of severe preeclampsia in the carriers of GG genotype (XbaI -351A/G polymorphism) and no association of the ESR1 gene PvuII -397T/C and XbaI -351A/G polymorphisms with severe and mild preeclampsia [24].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Estrogen Receptor Gene Polymorphism (T-397c Variant) in Patients With Premenstrual Syndrome

et al. 2020

View full text Add to dashboard Cite

The aim: of the study is to determine the frequency of polymorphism of estrogen receptor gene ESR1 (T-397C variant) in patients with premenstrual syndrome. Materials and methods: 50 women with diagnosis of premenstrual syndrome (the basic group) and 25 persons without it (the control group) were examined. Polymerase chain reaction was used to study T-397C polymorphism of estrogen receptor gene ESR1. Results: There was no significant difference in allele and genotype rates of ESR1 gene between persons with premenstrual syndrome and controls. TT genotype was determined in 24.0 % women in the control group and 24 % of patients in basic group (OR=1.00, 95 % CI=0.32-3.08, p=1.00), TC genotype – in 52.0 % and 46.0 % of individuals respectively (OR=0.79, 95 % CI=0.30-2.06, p=0.62), CC genotype – 24.0 % and 30.0 % of women respectively (OR=1.36, 95 % CI=0.45-4.07, p=0.59). Also, the frequency of T allele and C allele was similar in individuals with pathology and healthy women. There was no significant difference in allele and genotype rates of T-397C variant of ESR1 gene between patients with mild and severe forms of premenstrual syndrome and controls. Conclusions: There is no association of T-397C polymorphic variant of estrogen receptor gene ESR1 with the development of premenstrual syndrome.

show abstract

Association between the estrogen receptor α gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis

Cited by 10 publications

References 24 publications

Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of Central Russia

Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of Central Russia

A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

Assessment of Estrogen Receptor Gene Polymorphism (T-397c Variant) in Patients With Premenstrual Syndrome

Contact Info

Product

Resources

About