A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

Abstract

Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension disease. Some case–control studies reported the association between vascular endothelial growth factor (VEGF) gene polymorphisms (rs3025039, rs2010963) and PE risk. However, these associations were inconsistent in several studies. Therefore, we conducted this meta-analysis to assess the role of VEGF gene polymorphisms in PE more precisely. Methods: Eligible studies were searched in PubMed, Embase, Web of Science and Chinese (Chinese National Knowledge Infrastructure (CNKI) and WanFang) databases. Statistical analyses were performed by Stata 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. In addition, subgroup analyses, sensitive analyses and publication bias analyses were performed to further assess this meta-analysis. Results: In total, 21 studies were included in the meta-analysis covering 2018 cases and 2632 controls. There were significant associations between VEGF polymorphisms (rs3025039, rs2010963) and PE risk in the overall populations. In the subgroup analyses, we found that rs3025039 polymorphism was associated with the increased risk of PE among Chinese. As for rs2010963 polymorphism, a significant association was observed in subgroup of Caucasian. Conclusion: The present study suggested that the two VEGF gene polymorphisms (rs3025039, rs2010963) are associated with increased risk of PE in different ethnic groups, which means that the targets may be useful genetic markers for early prediction of PE.

Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

“…59 Over time, it has also been used to describe scenarios where other health outcomes are better than expected among Hispanic women. 57,60 The Role of Race and Ethnicity on the Pathophysiology of Preeclampsia Abnormalities of placental formation and development, 61e63 immunologic factors, 64,65 vascular changes, 66 and inflammation have all been identified as contributing to the pathophysiology of preeclampsia. 67 There has been a desire to investigate genetic causes of preeclampsia.…”

Increased Vascular Endothelial Growth Factor Serum Level and the Role of +936C/T Gene Polymorphism in Chronic Obstructive Pulmonary Disease

“…In 2017, Yu and colleagues found no statistically significant difference in the genotype and allelic frequencies of VEGF rs699947 and rs1570360 between COPD patients and control groups [39]. We investigated the relationship between VEGF rs3025039 and COPD as we found a wide range of studies that focused on this polymorphism and its relationship with various diseases, like pre-eclampsia [40], extracranial internal carotid artery stenosis and ischemic stroke [41], and bladder cancer [42], but only one study that described its involvement in COPD. Baz-Davila et al investigated the potential role of several SNPs in the susceptibility and progression of COPD in a Spanish population and found no association between rs3020539 and COPD [43].…”

The genetic risk factors for pregnancy‐induced hypertension: Evidence from genetic polymorphisms

“…A meta‐analysis by Duan et al found that VEGF gene rs3025039 T and rs2010963 C alleles significantly increased the risk of PE in the study population 31 . Additionally, subgroup analyses demonstrated that the two polymorphic alleles were associated with PE risk in Chinese and Caucasian populations, respectively 31 . Wang et al 32 also found that rs3025039 T and rs2010963 C alleles were closely associated with PE in Asian and European populations, respectively, but neither rs699947C/A nor rs1570360G/A was associated with PE risk in the included populations.…”