Association between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility

Wang, Honglin; Zhang, Xu; Wu, Wentao; Zhang, Mingyue; Sam, Napoleon Bellua; Niu, Lei

doi:10.1097/md.0000000000013163

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…34 A recent systematic review and meta-analysis revealed that there is a significant relationship between ASPN D14 polymorphism and knee OA. 41 Taipale et al reported that the carriage of the ASPN D15 allele is associated with the increased risk of symmetrical hand OA. 22 Moreover, the D14 repeat polymorphism of the ASPN gene was found to be associated with primary OA of the knees in a Mexican Mestizo population.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

et al. 2021

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Osteoarthritis (OA) is a degenerative joint disease, which occurs when the cartilage or cushion between the joints breaks down, leading to pain, stiffness, and swelling. OA is characterized by the degeneration of articular cartilage. 1 Several factors lead to the development of OA, including excess weight, injury, aging, and hormonal, environmental, and genetic factors, which are recognized as major risk factors for OA. 2 This disease occurs when mechanical stress and inflammatory mediators cause an imbalance in anabolic and catabolic processes of carcinogenesis. 3,4 Symptomatic knee OA occurs in 10% of men and 13% of women aged 60 years or above. 5 Knee OA is a common condition in Asian countries. In Iran, the incidence of knee OA is estimated at 19.4%

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Section: Discussionmentioning

confidence: 99%

Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

et al. 2021

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“…At present, many genes are reported to be related to the occurrence and development of OA by increasing susceptibility, enhancing cartilaginous matrix degradation, preventing cartilage from repair, increasing the expression of inflammatory factors, or promoting fibroblast transformation. First, the susceptibility genes of OA mainly include ASPN ( Wang et al, 2018 ), ADIPOQ ( Shang et al, 2019 ), AKNA ( Zhao et al, 2020a ), DPEP1 ( Zhang et al, 2021a ), rs1065080 ( Lu et al, 2019a ), TLR7 ( Wang et al, 2020a ), RTP4 ( Wang et al, 2020a ), CRIP1 ( Wang et al, 2020a ), ZNF688 ( Wang et al, 2020a ), TOP1 ( Wang et al, 2020a ), EIF1AY ( Wang et al, 2020a ), RAB2A ( Wang et al, 2020a ), ZNF281 ( Wang et al, 2020a ), UIMC1 ( Wang et al, 2020a ), and PRKACB ( Zhao, 2021 ). Second, the genes that promote the degradation of cartilage mainly include ADAMTS5 ( Jiang et al, 2021 ), ADAM12 ( Lv et al, 2017 ), JUN ( Rhee et al, 2017 ), PTGS2 ( Zhou et al, 2019a ), MMP1 ( Zhou et al, 2019a ), MMP3 ( Zhou et al, 2019a ), MMP13 ( Zhou et al, 2019a ), AGT ( Wang et al, 2020b ), and rs2830585 ( Zhou et al, 2019b ).…”

Section: Methodsmentioning

confidence: 99%

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Deng

Zong

et al. 2021

Front. Pharmacol.

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Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and subchondral bones. Although progress has been made in uncovering the molecular mechanism, the etiology of OA is still complicated and unclear. Nevertheless, there is no treatment method that can effectively prevent or reverse the deterioration of cartilage and bone structure. In recent years, in the field of pharmacology, research focus has shifted to disease prevention and early treatment rather than disease modification in OA. Biologic agents become more and more attractive as their direct or indirect intervention effects on the initiation or development of OA. In this review, we will discuss a wide spectrum of biologic agents ranging from DNA, noncoding RNA, exosome, platelet-rich plasma (PRP), to protein. We searched for key words such as OA, DNA, gene, RNA, exosome, PRP, protein, and so on. From the pharmacological aspect, stem cell therapy is a very special technique, which is not included in this review. The literatures ranging from January 2016 to August 2021 were included and summarized. In this review, we aim to help readers have a complete and precise understanding of the current pharmacological research progress in the intervention of OA from the biological aspect and provide an indication for the future translational studies.

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“…The encoded protein binds collagen and calcium, thus inducing collagen mineralization [8]. Additionally, ASPN regulates chondrogenesis by inhibiting transforming growth factor-β (TGF-β) gene expression that is commonly expressed in cartilaginous tissues [8,9]. ASPN contains a specific polymorphic D-repeat in the N-terminus region, ranging from 9-20 residues [6].…”

Section: Review Asporinmentioning

confidence: 99%

“…ASPN contains a specific polymorphic D-repeat in the N-terminus region, ranging from 9-20 residues [6]. There is an established association between the various D polymorphisms and increased risk of osteoarthritis, making this gene a possible candidate as a susceptibility gene to lumbar disc degeneration (LDD) [6,8,9]. A meta-analysis published in 2008 determined that the ASPN gene was shown to be upregulated with age and disc degeneration.…”

Section: Review Asporinmentioning

confidence: 99%

Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part Two of Two

Covarrubias¹,

Jarrah²

2021

Cureus

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Understanding genetic indicators is a fundamental aspect to characterizing the pathophysiology of chronic diseases such as intervertebral disc degeneration (IVDD). In our previous spinal genetics review, we characterized some more common genetic influencers in the context of IVDD. In this second part of our two-part comprehensive spinal genetics review, we characterize the more infrequently studied genes that have pathophysiological relevance. In doing so, we aim to expand upon the current gene-library for IVDD. The genes of interest include: asporin, cartilage intermediate layer protein , insulin-like growth factor 1 receptor, matrix metallopeptidase 9, and thrombospondin 2. Findings show that these genetic indicators have trends and polymorphisms that may have causal associations with the manifestation of IVDD. However, there is a narrow selection of studies that use genetic indicators to describe correlations to the severity and longevity of the pathology. Nevertheless, with the continued identification of risk genes involved with IVDD, the possibilities for refined models of gene therapies can be established for future treatment trials.

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Association between the aspartic acid D-repeat polymorphisms and osteoarthritis susceptibility

Abstract: Supplemental Digital Content is available in the text

Cited by 6 publications

References 29 publications

Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Genetic Predictors of Early-Onset Spinal Intervertebral Disc Degeneration: Part Two of Two

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