Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

Moghimi, Nasrin; Nasseri, Sherko; Ghafouri, Farzad; Jalili, Ali

doi:10.1111/1756-185x.14097

Cited by 6 publications

(4 citation statements)

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“…All eighteen studies [ 10 – 27 ] presented the OA of knee, hip and hand data. In the studies of the correlation between the GDF5 rs143383 SNP and OA of knee, hip and hand, the meta-analysis showed that GDF5 rs143383 SNP codominant heterozygote model (OR = 1.17, 95% CI 1.07–1.27) is associated with the susceptibility to OA of knee, hip and hand.…”

Section: Resultsmentioning

confidence: 99%

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis

Wang,

Di,

Yang

et al. 2023

J Orthop Surg Res

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Background Osteoarthritis (OA) is caused by a complex set of pathophysiological factors. The genetic factors involved in the occurrence and progress of the disease have been widely discussed by scholars. It was found that growth differentiation factor 5 (GDF5) gene polymorphisms may be linked to OA susceptibility, which has been controversial and needs to be further confirmed by an updated meta-analysis. Objectives We examined the association between GDF5 rs143383 single nucleotide polymorphism (SNP) and OA susceptibility. Methods All relevant articles that met the criteria are retrieved and included, and the search deadline is June 2022. The allele frequencies and different genotype frequencies of GDF5 rs143383 loci in each study were extracted and statistically analyzed by R4.1.3 software, and the different genetic models were analyzed based on their odds ratio (OR) and 95% confidence interval (CI). Results The meta-analysis explained that GDF5 rs143383 SNP was crucial correlated with OA in all patients with OA of knee, hip and hand. The codominant gene model in the whole crowd (OR = 1.17, 95% CI 1.07–1.27, P < 0.01) enlightened that OA was vitally associated with GDF5 gene polymorphism. At the same time, we did a subgroup analysis based on ethnicity. The codominant gene model (OR = 1.31, 95% CI 1.12–1.53, P < 0.01) in Asian population, the codominant homozygote model (OR = 1.28, 95% CI 1.14–1.43), codominant heterozygote gene model (OR = 1.12, 95% CI 1.01–1.23, P = 0.02), and dominant gene model (OR = 1.19, 95% CI 1.09–1.31, P < 0.01) in Caucasian are analyzed by subgroup analysis. It means that there is a momentous relationship between the GDF5rs143383 gene polymorphism and OA, especially among Caucasians. In addition, we also discussed different types of OA separately and discover that the GDF5rs143383 gene polymorphism was relevant for knee osteoarthritis (KOA) and hand osteoarthritis, and it was more significant in the Caucasian population. But due to the high heterogeneity in hip osteoarthritis, it could not be accurately concluded. Furthermore, we also analyzed the osteoarthritis of different genders and found that the GDF5 rs143383 SNP was associated with both men and women and was still significant in the Caucasian population. Conclusion We found a close association between osteoarthritis and GDF5rs143383SNP in this study. From the analysis of each group, we got the same conclusion in KOA and hand OA, but which need further verification in hip OA. Considering gender, we found a close relationship between GDF5 rs143383 SNP and OA of the knee, hip and hand, both for men and women. This conclusion is more obvious in Caucasian people.

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Section: Resultsmentioning

confidence: 99%

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis

Wang,

Di,

Yang

et al. 2023

J Orthop Surg Res

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“…40 Currently, the primary goal of OA treatment is to reduce OA patients' complaints of joint pain, swelling, and dysfunction. 41,42 Other OA medications and NSAIDs are only momentarily beneficial, and excessive use might have negative side effects. 43 Therefore, it is necessary to discover safe and effective strategies to alleviate the clinical symptoms of OA.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies

Li¹,

Zhu²,

Luo³

et al. 2023

DDDT

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Introduction: Osteoarthritis (OA) is a common chronic joint disease characterized by articular cartilage degeneration. OA usually manifests as joint pain, limited mobility, and joint effusion. Currently, the primary OA treatment is non-steroidal anti-inflammatory drugs (NSAIDs). Although they can alleviate the disease's clinical symptoms and signs, the drugs have some side effects. Selenium nanoparticles (SeNPs) may be an alternative to relieve OA symptoms. Materials and Results:We confirmed the anti-inflammatory effect of selenium nanoparticles (SeNPs) in vitro and in vivo experiments for OA disease in this study. In vitro experiments, we found that SeNPs could significantly reduce the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the major inflammatory factors, and had significant anti-inflammatory and anti-arthritic effects. SeNPs can inhibit reactive oxygen species (ROS) production and increased glutathione peroxidase (GPx) activity in interleukin-1beta (IL-1β)-stimulated cells. Additionally, SeNPs down-regulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) expressions, while up-regulated type II collagen (COL-2) and aggrecan (ACAN) expressions stimulated by IL-1β. The findings also indicated that SeNPs may exert their effects through suppressing the NF-κB p65 and p38/MAPK pathways. In vivo experiments, the prevention of OA development brought on by SeNPs was demonstrated using a DMM model. Discussion: Our results suggest that SeNPs may be a potential anti-inflammatory agent for treating OA.

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“…Генетические факторы играют важную роль в развитии и прогрессировании ОА [7]. Ряд исследований указывают на различия в ассоциациях отдельных полиморфных генетических маркеров с ОА коленного сустава у мужчин и женщин [8][9][10]. В результате полногеномных исследований (GWAS) выявлено более 120 однонуклеотидных полиморфизмов (SNP), ассоциированных с развитием ОА различных локализаций (p ≤ 5 × 10 Примечание: результаты получены методом MB-MDR с учетом коррекции на ковариаты, NH -количество значимых сочетаний генотипов, ассоциированных с повышенным риском развития ОА коленного сустава, beta H -коэффициенты логистической регрессии для рисковых сочетаний генотипов, WH -статистики Вальда для рисковых сочетаний генотипов, NL -число значимых сочетаний генотипов, ассоциированных с низким риском развития заболевания, beta L -коэффициенты логистической регрессии для протективных сочетаний генотипов, WL -статистики Вальда для протективных сочетаний генотипов, p perm -уровень значимости моделей после проведенного пермутационного теста (выполнено 1000 пермутаций) с учетом коррекции на ковариаты.…”

Section: остеоартрозunclassified

The role of polymorphism of candidate genes in the development of knee osteoarthritis in men of the Central Chernozem region of Russia

Novakov

Novakova

Churnosov

2023

SJCEM

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Knee osteoarthritis (OA) is a disease resulting from the interaction of many local and systemic risk factors, among which an important role is played by genetic (hereditary) factors. This disease affects both men and women, but there are certain differences in the development and progression of the disease in different sexes.Aim: To study associations of polymorphic loci of candidate genes with the risk of developing knee ОА in the male population of the Central Chernozem region of Russia.Material and Methods. The study sample included 410 men (208 patients with knee OA and 202 controls). Ten polymorphic loci of candidate genes were genotyped: rs2820436 and rs2820443 LYPLAL1, rs3771501 TGFA, rs11177 GNL3, rs6976 GLT8D1, rs1060105 and rs56116847 SBNO1, rs6499244 NFAT5, rs34195470 WWP2, rs143384 GDF5. The study of associations of polymorphic genetic loci with the development of the disease was carried out by the method of logistic regression, taking into account covariates (age, BMI). The MB-MDR method was used to study intergenic interactions of polymorphisms associated with the disease.Results and Discussion. It was found that nine out of ten polymorphic loci of candidate genes (with the exception of rs6976 GLT8D1) are associated with the formation of knee OA in men in four models of interlocus interactions (pperm ≤ 0.024). The rs3771501 TGFA polymorphic locus (included in three of the four most significant models of gene-gene interactions) demonstrates the greatest contribution to the development of the disease in men. Independent effects of the studied polymorphic loci of candidate genes in the development of knee OA in men have not been identified (р > 0,05).Conclusion. Polymorphic loci rs2820436 and rs2820443 LYPLAL1, rs3771501 TGFA, rs11177 GNL3, rs6976 GLT8D1, rs1060105 and rs56116847 SBNO1, rs6499244 NFAT5, rs34195470 WWP2, rs143384 GDF5 involved in the development of knee osteoarthritis in men in four models of intergenic interactions. Among the studied loci, rs3771501 of the TGFA gene has the greatest contribution to disease susceptibility.

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Frequency of Growth Differentiation Factor 5 rs143383 and asporin D‐repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran

Cited by 6 publications

References 40 publications

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis

The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis

The Protective Effect of Selenium Nanoparticles in Osteoarthritis: In vitro and in vivo Studies

The role of polymorphism of candidate genes in the development of knee osteoarthritis in men of the Central Chernozem region of Russia

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