Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese

Chang, Shun‐Jen; Hou, Ming‐Feng; Kao, Jau-Tsuen; Wu, Szu-Hsien; Hou, Linda A.; Tsai, Li-Yu

doi:10.1007/s10549-005-9137-0

Cited by 14 publications

(11 citation statements)

References 21 publications

(27 reference statements)

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“…It was noteworthy that a relatively greater percentage of chemotherapy-treated patients were ε4 positive than in the other two groups. This is consistent with prior work showing an association between breast cancer and ε4 status (Chang et al, 2005; Moysich et al, 2000; Porrata-Doria et al, 2010), though other studies have failed to find such an effect (Chang et al, 2006; Niemi et al, 2000; Yaylim et al, 2003). By comparison, in a meta-analysis Farrer et al (1997) found that 25.7% of a group of 6262 Caucasian healthy older adults were APOE ε4 positive, in contrast to patients with Alzheimer’s disease, of whom 58.5% were APOE ε4 positive.…”

Section: Discussionsupporting

confidence: 92%

Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study

McDonald¹,

Conroy²,

Smith³

et al. 2013

Brain, Behavior, and Immunity

171

151

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Cognitive changes related to cancer and its treatment have been intensely studied, and neuroimaging has begun to demonstrate brain correlates. In the first prospective longitudinal neuroimaging study of breast cancer (BC) patients we recently reported decreased gray matter density one month after chemotherapy completion, particularly in frontal regions. These findings helped confirm a neural basis for previously reported cognitive symptoms, which most commonly involve executive and memory processes in which the frontal lobes are a critical component of underlying neural circuitry. Here we present data from an independent, larger, more demographically diverse cohort that is more generalizable to the BC population. BC patients treated with (N = 27) and without (N = 28) chemotherapy and matched healthy controls (N = 24) were scanned at baseline (prior to systemic treatment) and one month following chemotherapy completion (or yoked intervals for non-chemotherapy and control groups) and APOE-genotyped. Voxel-based morphometry (VBM) showed decreased frontal gray matter density after chemotherapy, as observed in the prior cohort, which was accompanied by self-reported difficulties in executive functioning. Gray matter and executive symptom changes were not related to APOE ε4 status, though a somewhat greater percentage of BC patients who received chemotherapy were ε4 allele carriers than patients not treated with chemotherapy or healthy controls. These findings provide confirmatory evidence of frontal morphometric changes that may be a pathophysiological basis for cancer and treatment-related cognitive dysfunction. Further research into individual risk factors for such changes will be critical for development of treatment and prevention strategies.

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Section: Discussionsupporting

confidence: 92%

Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study

McDonald¹,

Conroy²,

Smith³

et al. 2013

Brain, Behavior, and Immunity

171

151

View full text Add to dashboard Cite

show abstract

“…Considering that the average frequency of the e4 allele previously described in a sample of Taiwanese women without BC was 5.4% (24), with a power of 80%, a confidence interval (CI) set at 95% and a case:control ratio of 1:3, we estimated an ideal sample size of 52 cases and 156 controls. The case group included patients with carcinoma in situ or invasive tumor histologically confirmed.…”

Section: Methodsmentioning

confidence: 99%

Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study

Cibeira

Giacomazzi

Aguiar

et al. 2014

Molecular and Clinical Oncology

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The purpose of this study was to evaluate the association between apolipoprotein E (APOE) allelic frequency, serum lipoproteins and breast cancer (BC). We conducted a nested case-control study within a cohort including 47 cases and 165 controls. Polymerase chain reaction-restriction fragment length polymorphism analyses of the APOE polymorphism were performed. In general, participants with the genotype including alleles e2 and e3 tended to have lower serum triglycerides, total cholesterol and low-density lipoprotein cholesterol levels and higher high-density lipoprotein (HDL) cholesterol levels compared to participants homozygous for the e3 allele and participants heterozygous for the e3 and e4 alleles, respectively. BC patients exhibited higher mean levels of total serum cholesterol (P=0.070), dietary fat intake (P=0.020) and dietary cholesterol intake (P=0.017) compared to control subjects. The allelic distribution between the two groups revealed that the presence of the e2 allele was positively associated with the absence of BC, whereas the e4 allele was positively associated with the BC case group (P=0.019). The distribution of the APOE genotypes was not significantly different between cases and controls (P=0.172). The concomitant presence of the e2 and e4 alleles was positively associated with the absence of BC and e4/e4 homozygosity was positively associated with BC (P=0.021). Our findings suggested that APOE polymorphism plays an important role in the development of BC, particularly when associated with higher serum triglyceride levels.

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“…After the discovery of the APOE gene and knowledge of its genetic variants, several studies have demonstrated the association between the APOE polymorphisms and chronic conditions, such as Alzheimer's disease[15], age-related cognitive decline[16], osteoporosis[17], breast cancer[18], end-stage renal disease[19], atherosclerosis[8], diabetes[20], coronary disease[21] and longevity[22]. Based on these, we aimed to assess the relation between APOE genotype groups with the prevalence of the major CVD risk factors and its possible association with the evolution of the studied phenotypes in a longitudinal study of Brazilian subjects randomly selected from an ethnically mixed urban population.…”

Section: Introductionmentioning

confidence: 99%

APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population

et al. 2010

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BackgroundCardiovascular diseases (CVD) are the main cause of death and disability in developed countries. In most cases, the progress of CVD is influenced by environmental factors and multifactorial inheritance. The purpose of this study was to investigate the association between APOE genotypes, cardiovascular risk factors, and a non-invasive measure of arterial stiffness in the Brazilian population.MethodsA total of 1493 urban Brazilian individuals were randomly selected from the general population of the Vitoria City Metropolitan area. Genetic analysis of the APOE polymorphism was conducted by PCR-RFLP and pulse wave velocity analyzed with a noninvasive automatic device.ResultsAge, gender, body mass index, triglycerides, creatinine, uric acid, blood glucose, blood pressure phenotypes were no different between ε2, ε3 and ε4 alleles. The ε4 allele was associated with higher total-cholesterol (p < 0.001), LDL-C (p < 0.001), total-cholesterol/HDL-C ratio (p < 0.001), LDL/HDL-C ratio (p < 0.001), lower HDL-C values (p < 0.001) and higher risk to obesity (OR = 1.358, 95% CI = 1.019-1.811) and hyperuricemia (OR = 1.748, 95% CI = 1.170-2.611). Nevertheless, pulse wave velocity (p = 0.66) measures were no different between genotypes. The significant association between APOE genotypes and lipid levels persisted after a 5-year follow-up interval, but no interaction between time and genotype was observed for lipids longitudinal behavior.ConclusionThe ε4 allele of the APOE gene is associated with a worse lipid profile in the Brazilian urban population. In our relatively young sample, the observed effect of APOE genotype on lipid levels was not translated into significant effects in arterial wall stiffness.

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Association between the apolipoprotein E genotypes and breast cancer patients in Taiwanese

Cited by 14 publications

References 21 publications

Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study

Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study

Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study

APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population

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