Association between temporomandibular disorders and pain in other regions of the body

Abstract

The pain from temporomandibular disorder (TMD) is often associated with physical symptoms of other chronic pain disorders and comorbidities, such as generalised muscle and joint pain. However, this association is not widely studied. To evaluate the prevalence of comorbid pain in joints, specifically in the knees, hips, ankles, shoulders, wrists and elbows, in individuals with and without TMD. We evaluated 337 patients from a public hospital in the city of Rio de Janeiro, Brazil. The Research Diagnostic Criteria for TMD questionnaire were used for the diagnosis of TMD. To assess the presence of other joint pain, the patients were asked to answer questions considering: the presence of pain in the knee, hip, ankle, shoulder, wrist and elbow joints and time duration of pain. Individuals with TMD are 5·5 times more likely to present with other joint pain compared with those without the disorder. TMD muscle disorders were most associated with a higher number of pain at the other locations. There was a significant association between the presence of pain at the other locations, muscle (P < 0·001) and joint disorders (P = <0·001), as well as age advance, in TMD participants, showed to be a covariate factor for pain at the other locations. Individuals with TMD showed a high prevalence of pain in other joints of the body when compared with individuals without the disorder, and knee pain was the most prevalent pain complaint.

Dopamine receptor D2 and ankyrin repeat domain containing one in temporomandibular disorder of adolescents

“…Since these proteins are encoded by the DRD2 and ANKK1 genes, both are strong candidates to be studied in situations in which stress, anxiety, and pain are present. In addition, TMD is frequently associated with other painful conditions in other regions of the body . Furthermore, our previous study found association between anxiety and TMD in this same population of adolescents; therefore, DRD2 and ANKK1 were chosen as candidate genes.…”

Prefrontal modulation during chewing performance in occlusal dysesthesia patients: a functional near-infrared spectroscopy study

“…Therefore, despite the fact that the chief complaints of OD patients are related to occlusal somatic symptoms, they may be expressed as the somatic discomfort in whole body. Recent studies found that TMD [55] and OFP [56,57] patients experienced somatic spreading of pain symptoms in congruence with their psychiatric state progression. From these findings [55][56][57], one could suggest that symptoms in OD patients spread throughout the body depending on somatization severity.…”

Dental genetics in Brazil: Where we are

“… An association between polymorphisms in the genes of estrogen receptors and the presence of temporomandibular disorders and chronic arthralgia (Quinelato et al., ). Association between Haplotypes of the RANK and OPG genes with chronic arthralgia in individuals with and without temporomandibular disorders (Bonato, Quinelato, Borojevic, et al., ; Bonato, Quinelato, De Felipe Cordeiro, et al., ). Association between ESRRB polymorphisms with comorbidity of temporomandibular disorders and rotator cuff disease (Bonato et al., ). …”

“…Temporomandibular disorders (TMD) are characterized by painful and/or dysfunctional changes involving the masticatory muscles and temporomandibular joints (TMJ) (Bender, 2014), and collectively, they are considered the most common cause of chronic pain in the orofacial region. According to the National Institute of Dental and Craniofacial Research (NIDCR), 5%-12% of the US population suffer or have suffered from problems related to TMD (Bonato, Quinelato, Borojevic, et al, 2017;Bonato, Quinelato, De Felipe Cordeiro, et al, 2017).…”

“…genes with chronic arthralgia in individuals with and without temporomandibular disorders (Bonato, Quinelato, Borojevic, et al, 2017;Bonato, Quinelato, De Felipe Cordeiro, et al, 2017). 3.…”