Association between systemic immune-inflammation index and psoriasis: a population-based study

Abstract

BackgroundThe systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state and immune response. Psoriasis is an immune-mediated disease notable for its chronic inflammation of the entire system. Our research sought to explore the latent link between psoriasis and SII.MethodsWe performed a cross-sectional investigation utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES, 2009-2014). Employing multivariate linear regression models and subgroup analysis, we sought to uncover the association between SII and psoriasis.ResultsThis study enrolled a total of 17,913 participants as part of its research cohort. Our multivariate linear regression analysis revealed a notable and positive correlation between SII and psoriasis [1.013 (1.000, 1.026)]. As SII tertiles increased, the risk of psoriasis demonstrated an upward trend. The significant dependence on this positive association were maintained in women, BMI(≥ 30 kg/m2),non-stroke and non-cancer subjects in subgroup analysis and interaction tests. Furthermore, we identified a significant association between SII and psoriasis, characterized by two consecutive inverted U-shaped patterns. Notably, the analysis revealed the most prominent inflection point at a specific value of 797.067.ConclusionsThe results indicate a significant correlation between elevated SII levels and the presence of psoriasis. However, to corroborate and strengthen these results, additional large-scale prospective studies are required.

Commentary: Association between systemic immune-inflammation index and psoriasis: a population-based study

“…The authors adjusted for important covariates such as age, gender, and race in their study, which is very commendable. However, due to the prolonged course of psoriasis and its heavy financial burden ( 1 – 3 ), we would highly encourage the authors to include the poverty index as an important covariate in this study to obtain more accurate findings. They can also elaborate on the definition of covariates such as smoking, alcohol consumption, etc., and whether this was done through questionnaires or specialized testing tools.…”

Inflammatory Hematological Ratios in Adolescents with Mental Disorders: A Scoping Review

“…Low-grade systemic inflammation is a persistent condition characterized by subclinical activation of systemic immunoinflammatory processes [ 1 , 2 ]. It is known that systemic inflammation is involved in the pathophysiology of cardiovascular [ 3 ], endocrine [ 4 ], dermatological [ 5 ], oncological [ 6 ], and neurological diseases [ 7 ]. There is also evidence of activation of immune and inflammatory mechanisms in mental disorders such as depression [ 8 , 9 , 10 ], schizophrenia [ 8 , 11 , 12 ], and anxiety disorders [ 13 ].…”