Association between synovial fluid levels of inorganic pyrophosphate and short term radiographic outcome of knee osteoarthritis.

Abstract

Objective-To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). Method-One hundred and thirty five consecutive patients referred to hospital with knee OA (59 men, 76 women; mean age 71 years, range 41-88) were followed prospectively for a median of 2 5 years (interquartile range 1-75-3-0). Synovial fluid (SF) aspirated at presentation (202 OA knees: 68 bilateral, 66 unilateral) was assessed for PPi content by radiometric assay. Knee radiographs at presentation and at final review were assessed for change in global (Kellgren)

Does Chondrocalcinosis Associate With a Distinct Radiographic Phenotype of Osteoarthritis in Knees and Hips? A Case–Control Study

“…The lack of association between osteophytosis and knee CC reported in this study is in keeping with some previous reports (14,25), while the lack of association between JSN and CC in knees with OA is in keeping with most previous studies (5,14,24,25,32). Taken together, these findings suggest that radiographic knee CC does not associate either with JSN or with osteophytosis at the knee.…”

“…The association between knee CC and attrition in knees with OA is supported by previous reports of association between calcium pyrophosphate (CPP) crystals, high synovial fluid pyrophosphate (PPi; a precursor for CPP crystals), and attrition in knees with OA (24,25). Similarly, in a prospective study, synovial fluid CPP crystals associated with incident attrition in knees with OA (OR adj 2.41 [95% CI 1.33-4.39]) (26).…”

Effect of alignment of the medial tibial plateau and X-ray beam on apparent progression of osteoarthritis in the standing anteroposterior knee radiograph

“…One group was a population-based cohort from Indianapolis, Indiana (17). The 2 clinical OA cohorts were drawn from patient populations in the UK at the University of Bristol (7) and the University of Nottingham (18). To be eligible for this analysis, subjects were required to have definite bilateral or unilateral knee OA at baseline (i.e., grades II-IV OA severity by the Kellgren and Lawrence [K/L] criteria [19]), measurable JSW (i.e., JSW Ͼ0 mm) at baseline, a repeat radiograph taken 2-3 years later, and no radiographic evidence of intercurrent knee surgery.…”

Research Progress in the Sensing Ensembles for Pyrophosphate

“…研究表明, PPi 能够参与许多生命过程中的能 量传递以及新陈代谢 [1] , 如在 DNA 聚合酶的催化下参 与 DNA 的复制, 据此可通过对 PPi 的传感实现 DNA 序 列的实时测定 [2] . PPi 还可作为潜在的生物标记物应用 于癌症 [3] 、软骨钙质沉着病 [4] 以及关节炎 [5,6] [16,17] , 一般只有在极性有机溶剂中才有 较好的选择性和灵敏度.…”