Association between stress and breast cancer in women: a meta-analysis

Santos, Míria Conceição Lavinas; Horta, Bernardo Lessa; Amaral, João Joaquim Freitas do; Fernandes, Paulo Henrique Palácio Duarte; Galvão, Cristina María; Fernandes, Ana Fátima Carvalho

doi:10.1590/s0102-311x2009001500010

Cited by 42 publications

(37 citation statements)

References 70 publications

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“…accumulation of the individual life events and total life event scores, finding similar tendencies in breast cancer risk behaviors. Our results agree with the recent metaanalysis of Santos et al (2009) who found a statistically significant relationship between stressful life events of high intensity and breast cancer.…”

Section: Discussionsupporting

confidence: 93%

Self-reported psychological stress and the risk of breast cancer: A case-control study

Kruk

2011

Stress

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The aim of this study was to examine the relationship between severe life events and breast cancer risk. This study was based on a case-control examination of 858 Polish invasive breast cancer cases and 1085 controls matched for age and place of residence. Data on life events, sociodemographic characteristic, reproductive factors, family history of breast cancer, current weight and height, and lifestyle habits were collected between January 2003 and May 2007 using a self-administered questionnaire. Odds ratios with 95% confidence intervals were estimated as the measure of the relationship between life event stress and breast cancer risk using unconditional logistic regression analyses. After adjustment for potential breast cancer risk factors, women with four to six individual major life events had 5.33 times higher risk for breast cancer, compared with those in the lowest quartile. Similarly, women with a lifetime life change score greater than 210 had about 5 times higher risk compared to women with corresponding scores in the range 0-70. Several life events (death of a close family member, personal injury or illness, imprisonment/trouble with the law, retirement) were significantly associated with breast cancer risk. These findings suggest that major life events can play an important role in the etiology of breast cancer.

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Section: Discussionsupporting

confidence: 93%

Self-reported psychological stress and the risk of breast cancer: A case-control study

Kruk

2011

Stress

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“…There is another trend in Kazakhstan: adverse living conditions of lower social strata of population living in rural areas is a risk factor for development of BC, which is consistent with some recent publications (Nosheen Fatima et al, 2010;Das et al, 2012). Several studies mention the role and significance of such factors like abortion, hereditary predisposition, and chronic stress (Collaborative Group on Hormonal Factors in Breast Cancer, 2004;Santos et al, 2009;Amir et al, 2010;Antonova et al, 2011). Our observation confirms such findings-the abortion (OR=2.67), hereditary predisposition (OR=3.36), and chronic stress (OR=3.61) was more common in cases of breast cancer, but to a lesser extent compared to other identified risk factors.…”

Section: Discussionsupporting

confidence: 77%

Risk Factors of Breast Cancer in Kyzylorda Oblast of Kazakhstan: a Case-Control Study

Toleutay¹,

Резник²,

Kalmatayeva³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer in Kazakhstan and its Kyzylorda oblast is the most prevalent cancer in women and features increasing trends of incidence. The aim of study was to reveal risk factors for breast cancer among women of Kyzylorda oblast of Kazakhstan. Materials and Methods: A hospital-based case-control study was conducted at Kyzylorda oblast Oncology Center, including 114 cases of breast cancer and 196 controls. Binary logistic regression analysis was performed. Results: Social and behavioral risk factors for breast cancer were evaluated, among which unfavorable living conditions, chronic stress, unilateral breastfeeding, breastfeeding less than 3 months and over 2 years, abortions, and hereditary predisposition were found to be related with increased breast cancer risk. Breastfeeding for 6-24 months was found to be protective. Conclusions: The findings may have significant impact on activity planning aimed towards breast cancer reduction among women in Kazakhstan.

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“…In addition, in their estimation a feeling of happiness and optimism significantly decreased BC risk (OR=0.75, 95%CI=0.64-0.86). In turn, Santos et al (2009) in their meta-analysis including the latter findings reported statistically significant increased BC risk among women who had reported experience of stressful life events of high intensity. In the recent Polish case-control study (858 cases, 1085 controls) women with four to six individual major life events had over 5-times higher risk for BC compared with those not reporting major life events experience (OR=5.33, 95%CI=4.01-8.21) (Kruk, 2012).…”

Section: Psychological Stressmentioning

confidence: 91%

Lifestyle Components and Primary Breast Cancer Prevention

Kruk¹

2015

Asian Pacific Journal of Cancer Prevention

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Breast cancer primary prevention is a high research priority due to the high psychological and economic costs. The disease is a multistep process and several risk factors have been recognized. Over the past three decades numerous studies have investigated the association of lifestyle with breast cancer, showing independent effects of various factors. We report here a summary of the present state of knowledge on the role of lifestyle patterns, such as physical activity, diet, smoking, hormone therapy, and experience of psychological stress in the modulation of breast cancer in women, and discuss commonly accepted biological mechanisms hypothesized as responsible for the associations. The findings indicate that regular physical activity of moderate to vigorous intensity is probably linked with the decreased breast cancer risk among postmenopausal females and suggestive for a decrease of the risk in premenopausal women. In contrast, the consumption of high-fat diet, alcohol intake, and use of combined estrogen and synthetic progestagen hormonal therapy may increase the risk. Epidemiological findings dealing with a role of smoking and experience of psychological stress are conflicting.

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Association between stress and breast cancer in women: a meta-analysis

Cited by 42 publications

References 70 publications

Self-reported psychological stress and the risk of breast cancer: A case-control study

Self-reported psychological stress and the risk of breast cancer: A case-control study

Risk Factors of Breast Cancer in Kyzylorda Oblast of Kazakhstan: a Case-Control Study

Lifestyle Components and Primary Breast Cancer Prevention

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