Association Between Smoking and p53 Mutation in Oesophageal Squamous Cell Carcinoma: A Meta-analysis

Wu, Xu; Zheng, Yanfang; Tang, Maolin; Li, X.F.; Zeng, Rong; Zhang, J.R.

doi:10.1016/j.clon.2015.02.007

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…However, there have been a variety of other cancers which have been investigated with a similar methodology. In esophageal squamous cell carcinoma, heavy smokers have been shown to have a two-times higher odds of P53 mutation than non-smokers [20], and in lung cancer, frequent alcohol drinkers had a 4.6-fold increased odds of having a P53 mutation [21]. Several studies in breast cancer have not shown any association between alcohol consumption and HER2 receptor expression [22] and to date, no studies have reported on the impact of cigarette smoking or alcohol consumption on GLUT1 expression in any type of cancer.…”

Section: Introductionmentioning

confidence: 99%

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain¹,

McManus

McQuaid³

et al. 2019

Cancer Causes Control

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Purpose To investigate the association between cigarette smoking, alcohol consumption, and esophageal adenocarcinoma survival, including stratified analysis by selected prognostic biomarkers. Methods A population-representative sample of 130 esophageal adenocarcinoma patients (n = 130) treated at the Northern Ireland Cancer Centre between 2004 and 2012. Cox proportional hazards models were applied to evaluate associations between smoking status, alcohol intake, and survival. Secondary analyses investigated these associations across categories of p53, HER2, CD8, and GLUT-1 biomarker expression. Results In esophageal adenocarcinoma patients, there was a significantly increased risk of cancer-specific mortality in ever, compared to never, alcohol drinkers in unadjusted (HR 1.96 95% CI 1.13-3.38) but not adjusted (HR 1.70 95% CI 0.95-3.04) analysis. This increased risk of death observed for alcohol consumers was more evident in patients with normal p53 expression, GLUT-1 positive or CD-8 positive tumors. There were no significant associations between survival and smoking status in esophageal adenocarcinoma patients. Conclusions In esophageal adenocarcinoma patients, cigarette smoking or alcohol consumption was not associated with a significant difference in survival in comparison with never smokers and never drinkers in fully adjusted analysis. However, in some biomarker-selected subgroups, ever-alcohol consumption was associated with a worsened survival in comparison with never drinkers. Larger studies are needed to investigate these findings, as these lifestyle habits may not only be linked to cancer risk but also cancer survival.

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Section: Introductionmentioning

confidence: 99%

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain¹,

McManus

McQuaid³

et al. 2019

Cancer Causes Control

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“…A recent study reported a strong indication that CS is the key factor of genomic instability and heterogeneity, which may lead to the initiation of diverse types of cancer, such as lung, bladder, and colorectal cancers (Kytola et al, ). Furthermore, CS may lead to the development of gene mutations which occurs in cell cycle–control p53 gene (TP53 in humans), which is a major cause of cancer development risk among various ethnic populations(Gibbons, Byers, & Kurie, ; Kytola et al, ; Liu et al, ; Wu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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Background Thymine‐DNA glycosylase (TDG) is an essential DNA‐repair enzyme which works in both epigenetic regulation and genome maintenance. It is also responsible for efficient correction of multiple endogenous DNA lesions which occur commonly in mammalian genomes. Research of genetic variants such as SNPs, resulting in disease, is predicted to yield clinical advancements through the identification of sensitive genetic markers and the development of disease prevention and therapy. To that end, the main objective of the present study is to identify the possible interactions between cigarette smoking and the rs4135050 variant of the TDG gene, situated in the intron position, among Saudi individuals. Methods TDG rs4135050 (A/T) was investigated by genotyping 239, and 235 blood specimens were obtained from nonsmokers and smokers of cigarette respectively. Results T allele frequency was found which showed a significant protective effect on Saudi male smokers (OR = 0.64, p = 0.0187) compared to nonsmoking subjects, but not in female smokers. Furthermore, smokers aged less than 29 years, the AT and AT+TT genotypes decreased more than four times the risk of initiation of smoking related‐diseases compare to the ancestral AA homozygous genotype. Paradoxically, the AT (OR = 3.88, p = 0.0169) and AT+TT (OR = 2.86, p = 0.0420) genotypes were present at a higher frequency in smoking patients aged more than 29 years as compared to nonsmokers at the same ages. Conclusion Depending on the gender and age of patients, TDG rs4135050 may provide a novel biomarker for the early diagnosis and prevention of several diseases caused by cigarette smoking.

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“…Thus, we still need to further investigated the in uence caused by maspin on tumor development. It is well known that P53 mutation was signi cantly related with smoking [30] and maspin was shown as signi cant association with P53 expression; however, few included studies explored the in uence of smoking on maspin expression. Besides, few studies conducted subgroup analyses strati ed by the TNM stage which was an important prognostic factor and we suspected that maspin may show very different prognostic signi cance in patients with different TNM stage.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Prognostic Significance of Maspin Expression in Resected Non-Small Cell Lung Cancer: A Meta-Analysis

Wang

Dong

Wang

et al. 2020

Preprint

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Objective To explore the association of maspin expression with clinical pathological parameters and prognosis in non-small cell lung cancer (NSCLC) who received the surgical therapy.Methods The EMBASE, Web of Science and PubMed were searched to identify eligible studies to 3 December, 2019. The correlation of maspin expression with clinicopathological characteristics and survival of resected NSCLC patients was assessed by the combined relative risk (RR) and hazard ratio (HR) with corresponding 95% confidence interval (CI), respectively. All statistical analyses were performed via the Stata 12.0 software.Results A total of 12 articles involving 1771 patients were included. The results manifested that maspin was more prevalent in lung squamous cell carcinoma (SCC) (RR=0.36, 95% CI: 0.22-0.60, P＜0.001) and significantly associated with P53 expression (RR=1.50, 95% CI: 1.00-2.24, P=0.048), while no significant correlation of maspin with other clinicopathological parameters such as the gender, age, tumor size, lymph node metastasis, tumor node metastasis (TNM) stage or differentiation status was observed. As for the prognosis representing as overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS), only significant association between maspin and CSS (HR=1.58, 95% CI: 1.16-2.15, P=0.003) was revealed. However, the subgroup analysis for OS based on the histology demonstrated that maspin expression was an unfavourable and favourable prognostic indicator in lung adenocarcinoma (HR=3.36, 95% CI: 1.44-7.87, P=0.005) and SCC (HR=0.44, 95% CI: 0.27-0.71, P=0.001), respectively.Conclusion Maspin expression was correlated with histology type and P53 expression, but no certain association of maspin with other clinicopathological characteristics or prognosis was observed in resected NSCLC. More well-designed prospective researches with big samples are still needed to further assess the clinicopathological and prognostic significance of maspin in NSCLC patients undergoing surgical resection.

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Association Between Smoking and p53 Mutation in Oesophageal Squamous Cell Carcinoma: A Meta-analysis

Cited by 9 publications

References 36 publications

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Clinicopathological and Prognostic Significance of Maspin Expression in Resected Non-Small Cell Lung Cancer: A Meta-Analysis

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