Association between site‐specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women

Kim, Semin; Cui, Jinrui; Rhyu, Jane; Guo, Xiuqing; Chen, Yii‐Der I.; Hsueh, Willa A.; Rotter, Jerome I.; Goodarzi, Mark O.

doi:10.1111/cen.13602

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…The previous study has identified variants in ESR1 and close proximity to RANKL showed a clear effect dependency on age for BMD [ 19 ]. According to recent studies, glucose homeostasis and anthropometric traits are associated with site-specific BMD and body mass index with age-specific BMD [ 46 , 47 ]. Meanwhile, it has been reported that epigenetic modifications are highly dynamic, age-, and tissue-specific, and sensitive to endogenous signals and/or environmental stimulation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

A genetic correlation scan identifies blood proteins associated with bone mineral density

Zhang

et al. 2022

BMC Musculoskelet Disord

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Background Osteoporosis is a common metabolic bone disease that is characterized by low bone mass. However, limited efforts have been made to explore the functional relevance of the blood proteome to bone mineral density across different life stages. Methods Using genome-wide association study summary data of the blood proteome and two independent studies of bone mineral density, we conducted a genetic correlation scan of bone mineral density and the blood proteome. Linkage disequilibrium score regression analysis was conducted to assess genetic correlations between each of the 3283 plasma proteins and bone mineral density. Results Linkage disequilibrium score regression identified 18 plasma proteins showing genetic correlation signals with bone mineral density in the TB-BMD cohort, such as MYOM2 (coefficient = 0.3755, P value = 0.0328) among subjects aged 0 ~ 15, POSTN (coefficient = − 0.5694, P value = 0.0192) among subjects aged 30 ~ 45 and PARK7 (coefficient = − 0.3613, P value = 0.0052) among subjects aged over 60. Conclusions Our results identified multiple plasma proteins associated with bone mineral density and provided novel clues for revealing the functional relevance of plasma proteins to bone mineral density.

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Section: Discussionmentioning

confidence: 99%

A genetic correlation scan identifies blood proteins associated with bone mineral density

Zhang

et al. 2022

BMC Musculoskelet Disord

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“…2 Currently, it has been recognized that patients with T2DM were associated with higher risk of fractures than non-diabetic patients, 3 BMD was associated with glucose metabolism. 4,5 Another study has also revealed the differences in the blood glucose levels among osteoporosis, low BMD, and normal BMD groups. 6 However, there was a study showed the detection rates of low BMD and osteoporosis have no significant differences among different glucose metabolism groups.…”

Section: Introductionmentioning

confidence: 99%

<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

Jia¹,

Liu²,

Wu³

et al. 2020

DMSO

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Background: Several studies have reported the relationship of diabetes mellitus (DM) and obesity with bone mineral density (BMD), but the conclusions remain unclear. This study aimed to provide more information for the relationship of plasma glucose and abdominal visceral fat (AVF) with BMD and bone mineral content (BMC) in women with different glucose metabolism status. Methods: Patients were screened by oral glucose tolerance test (OGTT) and were divided into three groups: normal glucose tolerance (NGT, n=132), pre-diabetes mellitus (pre-DM, n=28) and newly diagnosed type 2 DM (T2DM, n=27) groups. Plasma glucose concentrations, anthropometric measurements, body composition, and BMD were measured. Analysis of variance (ANOVA), pearson correlation, and multiple linear regression models were used to evaluate the relationship between BMD, plasma glucose, AVF, and other variables. Results: The percentage of subjects with osteoporosis or low BMD was 29.9%, and 66.7% subjects in T2DM group were significantly higher than that in the pre-DM (28.6%) and NGT (22.7%) groups (p=0.005 and p<0.001, respectively). Both BMD at femoral neck (FN) and lumbar spine (LS) of T2DM group were lower than those in NGT group (p=0.009 and p=0.003, respectively), and BMC of T2DM group was lower than those of NGT and pre-DM groups (p<0.001). The results of statistical analysis revealed that both two-hour plasma glucose (2-h PG) and age showed negative correlation with BMC, FN BMD, and LS BMD. AVF showed positive correlation with BMC and LS BMD. Furthermore, the lean mass (LM) showed independent positive effects on BMC. Conclusion: Our findings suggest that 1) Age is a strong negative predictor of bone mass. 2) A direct negative effect of increasing 2-h PG might be more prominent at bone mass in women. 3) A moderate increase in AVF is beneficial to bone mass, while excessive increase might be harmful. 4) LM is a positive predictor of BMC.

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“…The authors provide evidence for a non-essential anabolic effect of insulin that could be attributed to mechanical stimuli from lean mass (KIM et al, 2018). Therefore, further investigation of insulin levels and body composition, especially lean mass, is needed to understand this relationship in individuals with ED.…”

Section: Discussionmentioning

confidence: 97%

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

Lopes¹

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Esta tese é fruto de um longo trabalho e muita dedicação. Gostaria de agradecer aqui todas as pessoas e instituições fundamentais para o desenvolvimento do meu doutorado:Primeiramente à minha orientadora Ligia Martini, por desde cedo me guiar e acolher no mundo da pesquisa. Por ter acreditado e confiado em mim, contribuindo para o desenvolvendo das minhas habilidades acadêmicas e pessoais. Obrigada por ser meu porto seguro em meio aos desafios e dificuldades inerentes ao doutorado. À minha coorientadora Marle Alvarenga, pelo suporte na realização de uma pesquisa com um tema tão interessante e desafiador quanto os transtornos alimentares. Obrigada por me inspirar uma visão de nutrição cada vez mais humana e gentil. E aos alunos da Profª Ligia e Marle:

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Association between site‐specific bone mineral density and glucose homeostasis and anthropometric traits in healthy men and women

Abstract: Our findings suggest that (i) anabolic effects of insulin might work via mechanical loading from lean mass; (ii) a direct negative effect of increasing glucose might be more prominent at cortical-bone-rich sites in women; and (iii) lean mass is a strong positive predictor of bone mass.

Cited by 5 publications

References 44 publications

A genetic correlation scan identifies blood proteins associated with bone mineral density

A genetic correlation scan identifies blood proteins associated with bone mineral density

<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

Avaliação da saúde óssea em pacientes com anorexia nervosa e bulimia nervosa

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