&lt;p&gt;Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status&lt;/p&gt;

Jia, Xiaojiao; Liu, Lanxiang; Wu, Rui; Liu, Xiaoli; Liu, Binbin; Ma, Ning; Lü, Qiang

doi:10.2147/dmso.s245096

Cited by 9 publications

(10 citation statements)

References 39 publications

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“…However, pathogenic fat depots, notably in the abdomen, have been hypothesized to contribute more to bone disability [15][16][17]. A recent study on more than 650000 adults showed that a rise in WC led to an obvious and rapid increase in fracture risk, independent of the body mass index (BMI) level (three groups: normal, overweight, and obese) [18].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

Guo

Wang

et al. 2023

Journal of Diabetes Research

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Introduction. The interaction between diabetes, obesity, and bone metabolism was drawing increasing public attention. However, the osteometabolic changes in diabetes mellitus type 2 (T2DM) patients with abdominal obesity have not been fully revealed. This study is aimed at investigating the association between abdominal obesity indices and bone turnover markers among T2DM participants. Methods. 4351 subjects were involved in the METAL study. Abdominal obesity indices included neck, waist, and hip circumference, visceral adiposity index (VAI), lipid accumulation product (LAP), waist-to-hip ratio (WHR), and Chinese visceral adiposity index (CVAI). They were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), osteocalcin (OC), and intact N-terminal propeptide of type I collagen (P1NP). Results. Abdominal obesity indices were strongly negatively associated with β-CTX and OC. Among males, five indices were negatively correlated with β-CTX (BMI, WC, LAP, WHR, and CVAI) and OC (BMI, NC, WC, WHR, and CVAI). There were no significant associations with P1NP. Among females, all eight indices were negatively associated with β-CTX. Seven indices were negatively related to OC (BMI, NC, WC, HC, LAP, WHR, and CVAI). The VAI was negatively correlated with P1NP. Conclusions. The present study demonstrated that in T2DM, abdominal obesity had an obviously negative correlation with bone metabolism. Abdominal obesity indices were significantly negatively associated with skeletal destruction (β-CTX) and formation (OC). In routine clinical practice, these easily obtained indices could be used as a preliminary screening method and relevant factors for osteodysfunction incidence risk at no additional cost and may be of particular value for postmenopausal women in T2DM populations.

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Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

Guo

Wang

et al. 2023

Journal of Diabetes Research

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“…Finally, the BMD became higher. However, Jia et al [3] found in their study that BMD and BMC of the T2DM group were lower than those of the normal group. Our study suggested that blood sugar content and BMD of the lumbar spine had a curvilinear relationship.…”

Section: Discussionmentioning

confidence: 82%

“…Diabetes may cause a signi cant increase in the risk of osteoporosis, which has been proved [2].The BMD of T1DM patients decreases. However, the BMD of T2DM patients is usually normal and even becomes slightly higher [3][4][5]. The bone turnover of diabetes patients decreases and properties of bone materials and bone microstructure change.…”

Section: Introductionmentioning

confidence: 99%

Association of T2DM、Serum Glucose、HbA1c With Lumbar Spine Bone Mineral Density in 40-59 years adults: A Cross Sectional Study Based on the 2011-2018 NHANES Database

Liu¹,

Liu²,

Pan³

et al. 2021

Preprint

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Backgrounds:Our purpose is to discuss the relationship among the status and duration of T2DM, serum glucose, glycosylated hemoglobin(HbA1c), and lumbar spine bone mineral density (LSBMD).Methods:We selected participants whose age was 40-59 in the NHANES of 2011-2018 for a cross-sectional study. We used the multiple linear regression model to evaluate the status and duration of T2DM, serum glucose, HbA1c, and LSBMD had a linear correlation. We used the smooth curve fitting and threshold effect methods to explore the potential curvilinear relationship and inflection point, further analyzed the subgroups stratified by genders and race and completed the curve fitting.Result:Finally, 5,329 people met the standard. Finally, we found that the positively correlation between the status of T2DM and the LSBMD, however, the duration of T2DM was not associated with the LSBMD.We further used the smooth curve fitting method to explore. And then we found that blood glucose and level of HbA1c had a curvilinear relationship with the BMD of the lumbar spine in the model. The curve was U-shaped. After the saturation effect and threshold effect analysis, the inflection point was 7.77mmol/L and 5.4%, respectively. According to the further subgroup analysis, we found that the blood glucose and HbA1c of male non-Hispanic whites were positively correlated to the BMD of the lumbar spine. However, in female non-Hispanic black people and Mexican Americans, they had the relationship of a U-shaped curve with the BMD of the lumbar spine.Conclusion:The BMD of the lumbar spine of middle-aged people suffering from T2DM was significantly higher than those who do not suffer from diabetes. However, the duration of T2DM was not associated with the LSBMD.Generally speaking, blood glucose and level of HbA1c had a curvilinear relationship with the BMD of the lumbar spine. The curve was U-shaped (The inflection point was 7.77mmol/L and 5.4%, respectively). The blood glucose and HbA1c of male non-Hispanic whites were positively correlated to the BMD of the lumbar spine. However, in the female non-Hispanic black people and Mexican Americans, they had the relationship of a U-shaped curve with the BMD of the lumbar spine.

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“…Jia et al. found that 2-h plasma glucose negatively correlated with femoral neck aBMD and lumbar spine aBMD in women ( 20 ). However, the negative correlation was not observed in two studies about children ( 11 , 12 ).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Prediabetes and Bone Mass in Adolescents: Analysis of the National Health and Nutrition Examination Survey From 2005 to 2010

Yin

2021

Front. Endocrinol.

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ObjectiveThe purpose of this study was to observe the relationship between impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and bone mineral density (BMD) in different sites in adolescents.MethodsA retrospective study was conducted on adolescents age 12–19 years of the United States. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2005–2006, 2007–2008, and 2009–2010 cycles. IFG was defined as fasting plasma glucose (FPG) levels that were ≥5.6 and <7.0 mmol/L. IGT was defined as 2-h plasma glucose levels that were ≥7.8 and <11.1 mmol/L after the oral glucose tolerance test (OGTT).ResultsAfter controlling for age, gender, race, and body mass index (BMI) Z-score, adolescents in different categories of IGT had significantly different levels of areal BMD (aBMD) and bone mineral apparent density (BMAD) (IGT main effect: P < 0.05 for all, two-way ANOVA). There was no main effect between different categories of IFG with regard to aBMD and BMAD (P > 0.05). There was no interaction between IFG and IGT with regard to aBMD and BMAD (P > 0.05). In multiple regression analysis, the 2-h plasma glucose maintained an independent association with femoral neck aBMD (β = −0.011, 95% CI: −0.017~−0.006, P < 0.001, R2 = 0.012), total femur aBMD (β = −0.015, 95% CI: −0.021~−0.009, P < 0.001, R2 = 0.018), total spine aBMD (β = −0.015, 95% CI: −0.020~−0.010, P < 0.001, R2 = 0.018), and total spine BMAD (β = −0.002, 95% CI: −0.003~0.000, P = 0.006, R2 = 0.003).ConclusionThe present study demonstrates that BMD was decreased in adolescents with IGT. Two-hour plasma glucose, not FPG, negatively correlated with BMD. The effect of 2-h plasma glucose was consistent across the sites of bone.

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<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

Cited by 9 publications

References 39 publications

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

Association of T2DM、Serum Glucose、HbA1c With Lumbar Spine Bone Mineral Density in 40-59 years adults: A Cross Sectional Study Based on the 2011-2018 NHANES Database

The Relationship Between Prediabetes and Bone Mass in Adolescents: Analysis of the National Health and Nutrition Examination Survey From 2005 to 2010

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