Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis

Vyas, Neil; Companioni, Rafael Ching; Tiba, Melik; Alkhawam, Hassan; Catalano, Carmine; Sogomonian, Robert; Baum, Joel A. C.; Walfish, Aaron

doi:10.4251/wjgo.v8.i9.688

Cited by 27 publications

(28 citation statements)

References 25 publications

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“…The only non-significant finding for six quantiles of 25(OH)D concentration was an increased risk for pancreatic cancer at the highest quantile. In other studies, reduced risk was evident for gastric (59), kidney (45), and ovarian cancer (82). Why no inverse correlations with respect to 25(OH)D concentration was present for those cancers in the VDPP study is unclear.…”

Section: The Cohort Consortium Vitamin D Pooling Project Of Rarer Canmentioning

confidence: 72%

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant

2018

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The vitamin D-cancer prevention hypothesis has been evaluated through several types of studies, including geographical ecological studies related to indices of solar ultraviolet-B (UVB) dose (the primary source of vitamin D for most people), observational studies related to UVB exposure or serum 25-hydroxyvitamin D [25(OH)D] concentrations, laboratory studies of mechanisms, and clinical trials. Each approach has strengths and limitations. Ecological studies indirectly measure vitamin D production and incorporate the assumption that vitamin D mediates the effect of UVB exposure. Findings from observational studies with long follow-up times are affected by changing 25(OH)D concentrations over time. Most clinical trials have been poorly designed and conducted, based largely on guidelines for pharmaceutical drugs rather than on nutrients. However, three clinical trials do support the hypothesis. In general, the totality of the evidence, as evaluated using Hill's criteria for causality in a biological system, supports the vitamin D-cancer prevention hypothesis.

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Section: The Cohort Consortium Vitamin D Pooling Project Of Rarer Canmentioning

confidence: 72%

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

Grant

2018

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“…Since retrospective studies have demonstrated an association between hypovitaminosis D (vitamin D insufficiency and deficiency) and gastric adenocarcinoma, low vitamin D levels may also be associated with other steps in the carcinogenetic pathway [ 10 , 11 , 12 ]. However, no study has yet assessed associations between hypovitaminosis D and pre-malignant histopathological changes in the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the presence or absence of gastric incomplete intestinal metaplasia after gastric biopsy, patients were designated as either a control (no gastric intestinal metaplasia) or case (gastric intestinal metaplasia) subject. Serum 25-hydroxyvitamin D levels were classified according to definitions established by the Endocrine Society: 30–100 ng/dL was considered normal, with insufficient 25-hydroxyvitamin D levels or hypovitaminosis D subgrouped into two: vitamin D insufficiency (VDi; 20–29 ng/dL) and vitamin D deficiency (VDd; <20 ng/dL) [ 12 , 15 ]. Two categories were used to assess timing of vitamin D collection: fall-winter representing times of less daylight exposure (fall months included September, October, and November, and winter months included December, January, and February) and spring-summer, representative of months with more daylight exposure (spring months included March, April, and May, and summer months included June, July, and August).…”

Section: Methodsmentioning

confidence: 99%

“…Due to its known antineoplastic and antioxidant properties, several studies have explored the association between vitamin D levels and cancer progression. Indeed, low vitamin D levels are associated with an increased risk of several malignancies including breast, prostate, colorectal, and pancreatic cancers [ 8 , 9 , 10 , 11 , 12 ], and vitamin D supplementation has been used for cancer prophylaxis [ 13 ]. There is also mounting evidence that low vitamin D levels are associated with an increased risk of gastric adenocarcinoma and may represent a poor prognostic factor [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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A Case-Control Study of the Association between Vitamin D Levels and Gastric Incomplete Intestinal Metaplasia

2018

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Aim: Low circulating vitamin D levels are associated with gastric adenocarcinoma, but whether vitamin D levels are associated with premalignant gastric mucosal changes is unknown. Here, we determined associations between vitamin D levels and gastric incomplete intestinal metaplasia, a known gastric adenocarcinoma risk factor. Methods: This was a retrospective, unmatched, case-control study comparing serum 25-hydroxyvitamin D levels among subjects with gastric incomplete intestinal metaplasia (cases; n = 103) and those without gastric incomplete intestinal metaplasia (controls; n = 216). The 25-hydroxyvitamin D levels were categorized as normal (30–100 ng/dL), vitamin D insufficiency (VDi; 20–29 ng/dL), and vitamin D deficiency (VDd; <20 ng/dL). Using multivariable logistic regression, odds ratios (ORs) were calculated and adjusted to age, gender, ethnicity, body mass index, history of hypertension or diabetes mellitus, and timing of vitamin D collection to assess associations between 25-hydroxyvitamin D levels and gastric incomplete intestinal metaplasia. Results: A majority of case subjects were male, Hispanic, and did not have hypertension or diabetes mellitus. The average serum 25-hydroxyvitamin D level was significantly lower in the intestinal metaplasia group than the control group (19.7 ng/dL vs. 34.7 ng/dL; p < 0.001). Hypovitaminosis D was more common in subjects with incomplete intestinal metaplasia in a multivariable regression model (OR 54.1, 95% CI 21.8–134.3; p < 0.001). VDd (OR 129.0, 95% CI 43.7–381.2; p < 0.001) and VDi (OR 31.0, 95% CI 11.9–80.3; p < 0.001) were more common in patients with incomplete intestinal metaplasia than healthy subjects, with VDd slightly more prevalent than VDi (OR 4.0, 95% CI 1.7–9.6; p < 0.001). Conclusions: Vitamin D deficiency and insufficiency are more common in patients with gastric incomplete intestinal metaplasia than healthy subjects and may play a role in the development of premalignant phenotypes related to gastric adenocarcinoma.

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“…Later in the disease phase, there is bleeding which leads to anemia. [15] Vitamin D plays an important role during tumorigenesis. Increased levels of serum Vitamin D reduce the risk of gastric cancer.…”

Section: Esophageal Cancermentioning

confidence: 99%

Untitled

2018

J Lab Physicians

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Vitamin D serves as a precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Low Vitamin D levels have been implicated in numerous disease processes including fracture risk, falls, cardiovascular disease, hypertension, diabetes mellitus, and cancers. Metabolite of 1, 25-dihydroxyvitamin D3 (1,25[OH]2D3) regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)2D3 serves various functions such as maintaining the integrity of epithelial barrier and absorption of calcium and phosphate, and the host's defense against pathogens, and the inflammatory response by several types of secretory and immune cells. Although epidemiological data remain inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for Vitamin D, results from some correlating studies strongly suggest that Vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding Vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome. The present review highlights the role of Vitamin D in cancer of the gastrointestinal tract including esophagus, gastric (stomach), liver, pancreas, and colon.

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Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis

Cited by 27 publications

References 25 publications

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

A Review of the Evidence Supporting the Vitamin D-Cancer Prevention Hypothesis in 2017

A Case-Control Study of the Association between Vitamin D Levels and Gastric Incomplete Intestinal Metaplasia

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