Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis

Patel, Sanjeev; Farragher, Tracey; Berry, Jacqueline; Bunn, Diane; Silman, Alan J.; Symmons, Deborah

doi:10.1002/art.22722

Cited by 215 publications

(162 citation statements)

References 21 publications

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“…Our findings are significantly similar with those of a study conducted by Patel et al 16 which covered 309 patients with inflammatory polyarthritis for less than four months. In that study, vitamin D level was lower in patients experiencing more disease activity at the early stage and after one year of follow-up and the incidence of RA was higher among the individuals with lower serum vitamin D levels.…”

Section: Discussionsupporting

confidence: 92%

Serum Vitamin D Level is Inversely Associated With Anti-Cyclic Citrullinated Peptide Antibody Level and Disease Activity in Rheumatoid Arthritis Patients

Wang

Zhang²,

Wang³

et al. 2016

Arch Rheumatol

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Objectives: This study aims to assess the relationship between serum vitamin D and anti-cyclic citrullinated peptide (anti-CCP) antibody levels, as well as disease activity in patients with newly diagnosed rheumatoid arthritis (RA). Patients and methods: These measurements were conducted between January 2014 and June 2014. Serum 25-hydroxy vitamin D (25-OH-D), anti-CCP antibody, and erythrocyte sedimentation rates were measured in a cohort of 154 patients (66 males, 88 females; mean age 53.5±12.4; range 29 to 79 years) with early RA. A control group of 60 healthy participants (25 males, 35 females; mean age 51.4±10.3; range 25 to 75 years) was only evaluated for serum 25-OH-D levels. Disease activity was measured by calculating the 28-Joint Disease Activity Score. Blood samples were drawn from cubital veins. After centrifugation, serum was collected and stored under minus 20 degrees. Results: Vitamin D deficiency was more prevalent in RA group compared with control group (48.70% vs. 30.00%, p<0.05). Serum 25-OH-D levels were lower in RA group (19.46±8.20 ng/mL) than control group (23.18±6.71 ng/mL) (p<0.05). In the RA group, serum 25-OH-D levels were negatively correlated to anti-CCP antibody levels (rs= -0.360, p<0.001), erythrocyte sedimentation rate (rs= -0.270, p<0.001), age of patients (rs= -0.602, p<0.001), and disease activity (rs= -0.249, p<0.05), respectively. Serum 25-OH-D level did not vary according to sex in the RA group. In control group, females had lower serum rs=0.404). In addition, serum 25-OH-D level was also negatively associated with age in control group (p<0.001, rs= -0.578). There were no differences between RA group and control group in terms of age and sex ratio. Conclusion: Serum 25-OH-D level was negatively correlated to anti-CCP antibody level and disease activity, which implied the therapeutic role of serum 25-OH-D in RA.

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Section: Discussionsupporting

confidence: 92%

Serum Vitamin D Level is Inversely Associated With Anti-Cyclic Citrullinated Peptide Antibody Level and Disease Activity in Rheumatoid Arthritis Patients

Wang

Zhang²,

Wang³

et al. 2016

Arch Rheumatol

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“…Vitamin D deficiency has been found to be associated with a higher incidence of RA 16 as well as more active disease progression 17,18,19 , but this was not confirmed in other studies 20,21 . It may therefore be that the increased risk of developing focal bone erosions in patients with RA is related with low bone mineral density (BMD), low levels of 25(OH) vitamin D (25OHD), and secondary hyperparathyroidism.…”

mentioning

confidence: 79%

Relationship of Focal Erosions, Bone Mineral Density, and Parathyroid Hormone in Rheumatoid Arthritis

Rossini

Bagnato²,

Frediani³

et al. 2011

J Rheumatol

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Objective. To investigate the relationship among focal bone erosions and bone mineral density (BMD), 25(OH) vitamin D (25OHD), and parathyroid hormone (PTH) values in patients with rheumatoid arthritis (RA). Methods. The study included 1191 RA patients (1014 women, 177 men, mean age 58.9 +/- 11.1 yrs) participating in a multicenter, cross-sectional study. Results. Radiographic evidence of typical bony erosions on hands or forefeet was found in 64.1% of patients. In those with bone erosions as compared to those without, mean BMD Z score values were significantly lower at both the spine (-0.74 +/- 1.19 vs 0.46 +/- 1.31; p = 0.05) and the hip (-0.72 +/- 1.07 vs -0.15 +/- 1.23; p <0.001). In the subgroup of patients not taking vitamin D supplements, PTH levels were significantly higher in those with erosive arthritis (25.9 +/- 14.0 vs 23.1 +/- 11.6 pg/ml; p = 0.01); whereas the 25OHD concentrations were very similar in the 2 groups. The mean differences for BMD and PTH among the erosive and nonerosive RA remained statistically significant when values were simultaneously adjusted for all disease and mineral metabolism factors (i.e., age, sex, menopause, disease duration, Disease Activity Score 28-joint count, Health Assessment Questionnaire, activities of daily living, Steinbrocker functional state, glucocorticoid therapy, body weight, and bisphosphonate treatment). Conclusion. Our results suggest that the presence of bone erosions in RA correlates with low BMD levels and high PTH levels, and that these associations are independent of the degree of functional impairment and other common determinants of bone mass and mineral metabolism in adults with RA. These findings suggest that treatments to prevent bone loss or suppress PTH levels might positively affect the progression of bone erosions in RA. (First Release April 1 2011; J Rheumatol 2011;38:997-1002; doi:10.3899/jrheum.100829

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“…Both laboratory and clinical studies have provided evidence that vitamin D deficiency is an important environmental factor that can increase the prevalence of certain autoimmune diseases, such as MS [55][56][57] , Crohn disease [58] , diabetes mellitus [59,60] , systemic lupus erythematosus (SLE) [61,62] , asthma [63] , RA [64] , Sjögren's syndrome, systemic vasculitis and antiphospholipid syndrome [65] . A correlation between reduced intake of vitamin D and prevalence of the diseases can be found, which raises the possibility that serum vitamin D level is important for the pathogenesis of autoimmune diseases.…”

Section: Functionsmentioning

confidence: 99%

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

Zhang

2010

Neurosci. Bull.

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Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis

Cited by 215 publications

References 21 publications

Serum Vitamin D Level is Inversely Associated With Anti-Cyclic Citrullinated Peptide Antibody Level and Disease Activity in Rheumatoid Arthritis Patients

Serum Vitamin D Level is Inversely Associated With Anti-Cyclic Citrullinated Peptide Antibody Level and Disease Activity in Rheumatoid Arthritis Patients

Relationship of Focal Erosions, Bone Mineral Density, and Parathyroid Hormone in Rheumatoid Arthritis

Role of vitamin D in immune responses and autoimmune diseases, with emphasis on its role in multiple sclerosis

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