Association between serum uric acid and motor subtypes of Parkinson’s disease

Lolekha, Praween; Wongwan, Piyanat; Kulkantrakorn, Kongkiat

doi:10.1016/j.jocn.2015.02.015

Cited by 36 publications

(32 citation statements)

References 11 publications

(17 reference statements)

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“…The principal finding was that serum UA levels and UA/Cr ratios in PACG patients were lower compared with sex and age-matched control group subjects, in addition, UA levels were found to be associated with the severity of PACG. The serum UA/Cr ratio was used to reduce the possible interference caused by sex and differences in renal function [20]. These data suggested a possible role of UA in the pathogenesis of PACG.…”

Section: Discussionmentioning

confidence: 99%

“…UA has been hypothesized to have a protective effect on the central nervous system against oxidative damage [17, 18]. Lolekha P et al [19] and Vieru E et al [20] reported that patients with Parkinson's disease showed significantly lower serum UA and uric acid/creatinine (UA/Cr) ratio than control. Whether serum UA levels are changed and involved in the pathophysiological mechanisms of PACG remained unclear.…”

Section: Introductionmentioning

confidence: 99%

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The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Shao

Tang

et al. 2016

Oncotarget

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Uric acid (UA) is a major antioxidant molecule and has been hypothesized to have a protective effect on the central nervous system against oxidative damage. We prospectively investigated the serum concentration of UA in primary angle closure glaucoma (PACG), and explored the association between serum concentration of UA and the severity of PACG. Using a retrospective case-control study design, 886 PACG subjects and 994 control subjects who attended the Eye & ENT Hospital of Fudan University, were eligible for this study. Glaucoma severity was classified as mild (MD ≤ 6.00 dB), moderate (12 dB ≥ MD > 6 dB) and severe (MD > 12 dB) based on the MD (mean deviation). The levels of UA were significantly lower (p = 0.025) in PACG (0.286 ± 0.082 mmol/l) compared with control (0.295 ± 0.085 mmol/l). The mean serum UA levels were lowest in the severe group (0.281 ± 0.074 mmol/l) followed by moderate (0.282 ± 0.080 mmol/l) and mild (0.297 ± 0.090 mmol/l) with significant differences among the three groups (p = 0.032). In multivariate regression analysis, there was a significant negative correlation between UA level and vertical cup-disc ratio (B = −0.165, p = 0.035). Significantly lower serum UA concentration in PACG and its negative association with disease severity presented it as an important candidate in reaction to oxidative stress in glaucoma pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Shao

Tang

et al. 2016

Oncotarget

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“…As we are aware, UA is also a biomarker of renal function, and thus, the UA/Cr ratio was used to reduce any possible interference in the interpretation of results caused by differences in renal function (Lolekha et al. ).…”

Section: Methodsmentioning

confidence: 99%

Association of serum uric acid levels with primary open‐angle glaucoma: a 5‐year case–control study

Shao

et al. 2018

Acta Ophthalmologica

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“…Recently, the association between serum urate levels and PD has gained intensive interests, but results of these studies have been inconsistent. Some studies have shown a clear trend of lower serum urate levels in PD and subgroups based on sex [9–17], while others showed no significant variation of lower serum urate levels in PD [18–23]. Our previous studies showed that the serum UA levels in PD patients were significantly lower than sex and age-matched healthy controls and the UA concentrations were decreased with the deterioration of the illness[24].…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid levels in patients with Parkinson’s disease: A meta-analysis

et al. 2017

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BackgroundLower serum uric acid (UA) levels have been reported as a risk factor in Parkinson’s disease (PD). However, the results have been inconsistent so far.ObjectivesThe aim of the present study was to clarify the potential relationship of uric acid with PD.MethodsComprehensive electronic search in pubmed, web of science, and the Cochrane Library database to find original articles about the association between PD and serum uric acid levels published before Dec 2015. Literature quality assessment was performed with the Newcastle-Ottawa Scale. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Heterogeneity across studies was assessed using I2 and H2 statistics. Sensitivity analyses to assess the influence of individual studies on the pooled estimate. Publication bias was investigated using funnel plots and Egger’s regression test. Analyses were performed by using Review Manager 5.3 and Stata 11.0.ResultsThirteen studies with a total of 4646 participants (2379 PD patients and 2267 controls) were included in this meta-analysis. The current results showed that the serum UA levels in PD patients were significantly lower compared to sex and age-matched healthy controls (SMD: -0.49, 95% CI: [-0.67, -0.30], Z = 5.20, P < 0.001) and these results showed no geographic regional (Asia: SMD = −0.65, 95% CI [−0.84, −0.46], Z = 6.75, p <0.001; Non-Asia: SMD = −0.25, 95% CI [−0.43, −0.07], Z = 2.70, p = 0.007) and sex differences (women: SMD = −0.53, 95% CI [−0.70, −0.35], z = 5.98, p <0.001; men: SMD = −0.66, 95% CI [−0.87, −0.44], z = 6.03, p <0.001). Serum UA levels in middle-late stage PD patients with higher H&Y scales were significantly lower than early stage PD patients with lower H&Y scales (SMD = 0.63, 95% CI [0.36,0.89], z = 4.64, p <0.001).ConclusionsOur study showed that the serum UA levels are significantly lower in PD and the level is further decreased as the disease progresses. Thus it might be a potential biomarker to indicate the risk and progression of PD.

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Association between serum uric acid and motor subtypes of Parkinson’s disease

Cited by 36 publications

References 11 publications

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study

Association of serum uric acid levels with primary open‐angle glaucoma: a 5‐year case–control study

Serum uric acid levels in patients with Parkinson’s disease: A meta-analysis

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