Association Between Serum Uric Acid and Development of Type 2 Diabetes

Abstract

OBJECTIVETo systematically evaluate the association between serum uric acid (SUA) level and subsequent development of type 2 diabetes.RESEARCH DESIGN AND METHODSWe searched Medline (31 March from 1966 to 2009) and Embase (31 March from 1980 to 2009) for observational cohort studies examining the association between SUA and the risk of type 2 diabetes by manual literature search. Relative risks (RRs) for each 1 mg/dl increase in SUA were pooled by using a random-effects model. The studies included were stratified into subgroups representing different study characteristics, and meta-regression analyses were performed to investigate the effect of these characteristics on the association between SUA level and type 2 diabetes risk.RESULTSThe search yielded 11 cohort studies (42,834 participants) that reported 3,305 incident cases of type 2 diabetes during follow-up periods ranging from 2.0 to 13.5 years. The pooled RR of a 1 mg/dl increase in SUA was 1.17 (95% CI 1.09–1.25). Study results were consistently significant (i.e., >1) across characteristics of participants and study design. Publication bias was both visually and statistically suggested (P = 0.03 for Egger's test, 0.06). Adjustment for publication bias attenuated the pooled RR per mg/dl increase in SUA (RR 1.11 [95% CI 1.03–1.20]), but the association remained statistically significant (P = 0.009).CONCLUSIONSThe current meta-analysis suggests that SUA level is positively associated with the development of type 2 diabetes regardless of various study characteristics. Further research should attempt to determine whether it is effective to utilize SUA level as a predictor of type 2 diabetes for its primary prevention.

Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

“…Hence, the variations in uric acid level may be due to gender-dependent differences in the range of uric acid. The overall prevalence of hyperuricemia is 28% which is comparable with the results obtained by a study conducted in Nigeria who reported the prevalence rate to be 25% [7] and also with a study conducted by Ito H. in Japan who reported the prevalence to be 25% (9).Hyperuricemia in diabetes mellitus II is also shown by other various studies [16,17,18].In contrast to these findings, some researchers have also shown negative association between uric acid and diabetes. Cook et al explained higher mean serum uric acid values in prediabetic patients than in recently diagnosed diabetics and lower values in diabetics.…”

Elevated levels of serum uric acid and insulin resistance are associated with nonalcoholic fatty liver disease among prediabetic subjects

“…Since NAFLD is a hepatic manifestation closely related to elevated levels of SUA and insulin resistance, this association has been studied in several studies among T2DM subjects. 12,13 Compared with non diabetic subjects, T2DM are believed to have an increased risk of developing NAFLD, but the true prevalence of the disorder among prediabetic subjects has not been systematically assessed. In addition, so far, population-based data to determine whether SUA and insulin resistance levels are associated with NAFLD in different stages of impaired glucose regulation, in particular prediabetic states, is scarce.…”

Hyperuricemia: From the Evolution of Species to Cardiovascular Risk

“…Molteplici studi epidemiologici hanno dimostrato che le concentrazioni ematiche di acido urico predicono la progressione della malattia renale cronica (19), lo sviluppo dello stroke (20), e si associano a ipertensione (21), diabete (22), sindrome metabolica (23). La relazione tra acido urico e scompenso cardiaco appare più controversa, con metanalisi che escludono tale agente dai principali determinanti dello scompenso nella popolazione generale (24), mentre al contrario l'uricemia sembra prevedere in maniera efficace la mortalità cardiovascolare, l'infarto del miocardio, lo stroke (25,26).…”