Association between serum uric acid levels and metabolic markers in patients with type 2 diabetes from a community with high diabetes prevalence

Abstract

Background The importance of uric acid has been increasingly appreciated because of its association with the development of diabetes mellitus and related diseases. Objective This study was undertaken to evaluate the association of serum uric acid (SUA) level with different clinical and biochemical parameters in patients with type 2 diabetes from Saudi Arabia. Methods Clinical and biochemical data from the patients were obtained and assessed in a cross‐sectional design. Relationships between SUA level and various clinical and biochemical parameters were analysed. Results SUA level was positively associated with increased incidence of cardiovascular diseases (CVD) in patients with abnormal eGFR (<90 mL/min/1.73 m2). HbA1c was found to be inversely associated with hyperuricemia in patients with normal eGFR level (≥90 mL/min/1.73 m2). Incidence of metabolic syndrome did not show any relationship with SUA level. However, the incidence of hypertension, a component of metabolic syndrome, was significantly higher among patients with hyperuricemia. Waist circumference and serum triglycerides were higher, whereas serum high‐density lipoprotein level was lower in patients with higher SUA level. Patients with hyperuricemia had higher incidence of CVDs than those of the normouricemic group. Conclusion SUA level was positively associated with incidence of cardiovascular diseases CVD in patients with abnormal eGFR. HbA1c correlated significantly with SUA level in patients with normal eGFR. Incidence of metabolic syndrome did not show any association with SUA level. Incidence of hypertension, waist circumference and serum triglycerides were significantly higher and serum high‐density lipoprotein level was lower in patients with higher SUA level.

Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes

“… 19 In Saudi Arabia, data on the associations of hyperuricemia or uric acid levels with metabolic factors among diabetic and non-diabetic patients are limited. 20–22 Additionally, gender-specific differences in such associations have never been the focus of any research. The objective of the current study was to detect gender-specific and age-specific differences in the uric acid levels and associated risk factors among patients with type-2 diabetes.…”

Icariin Protects Mouse Insulinoma Min6 Cell Function by Activating the PI3K/AKT Pathway

“…UA, a product of purine metabolism, is highly associated with diabetes mellitus [ 17 ]. Over-expression of UA was shown to be related to metabolic syndrome, which, in turn, is associated with the development and progression of T2D [ 18 ]. UA was found to stimulate oxidative stress and inhibit the proliferation of pancreatic β-cells by activating adenosine monophosphate-activated protein kinase [ 19 ].…”

Study of the incidence of hyperuricemia in young males’ population with rapid entry into the plateau of 4 500m

“…In China, high uric acid (HUA) is defined as the level of serum uric acid (SUA) beyond 420 μmol/L, according to the consensus of Chinese experts in 2017 [1] . Till now, thousands of studies investigated that besides gout, the metabolism disorders of UA is associated with the development of renal dysfunction, endocrine metabolism disorders and cardiovascular and cerebrovascular diseases [2][3][4][5][6][7][8][9][10][11][12][13] and it may even induce or aggravate cancer [3] . Due to the special geographical environment, the retrospective studies showed that prevalence rate of hyperuricemia is generally higher in the plateau area than that in the plain area [1] .…”