Association between Serum Prolactin and Metabolic Disorders: a Systematic Review

Yang, Zaibo; She, Junsen; Zhou, Congcong; Liangshan, Mu

doi:10.1101/2020.08.25.20180182

Cited by 1 publication

(4 citation statements)

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“…An expanding body of clinical evidence suggests the involvement of PRL in metabolic homeostasis, encompassing aspects such as body weight regulation and functions within AT and the pancreas. It is also indicated that PRL's effect on metabolic homeostasis largely depends on its circulating concentration [26,27,36]. In contrast to low and very high PRL levels, which have deleterious metabolic consequences, a specific range of PRL values benefits the metabolism.…”

Section: The Effects Of Prolactin On Metabolismmentioning

confidence: 99%

“…Interestingly, deficient levels of PRL (≤7 µg/L) have been associated with a similar degree of impairment of metabolic homeostasis [33,37]. Low PRL levels are associated with a higher prevalence of type 2 diabetes (T2D), IR, glucose intolerance, MS, AT dysfunction, ß-cell dysfunction, NAFLD, and cardiovascular events in humans [27,36].…”

Section: The Effects Of Prolactin On Metabolismmentioning

confidence: 99%

“…In contrast, moderately high PRL levels correlate with metabolic protection [27,36]. Macotela et al presented the concept of moderately elevated PRL levels as a part of a homeorhetic response to either physiological (e.g., pregnancy, lactation, stress) or pathological (e.g., obesity and MS) metabolic challenges, allowing a series of metabolic adaptations to deal with physio-pathological demand [27].…”

Section: The Effects Of Prolactin On Metabolismmentioning

confidence: 99%

“…These mechanisms may ultimately contribute to metabolic disorders in the presence of low PRL levels [36,59].…”

Section: Mechanisms Mediating the Metabolic Action Of Prolactinmentioning

confidence: 99%

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Prolactin in Polycystic Ovary Syndrome: Metabolic Effects and Therapeutic Prospects

Mastnak,

Herman,

Ferjan

et al. 2023

Life

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder in premenopausal women, characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Patients frequently present comorbidities, including obesity, insulin resistance, and impaired glucose and lipid metabolism. The diverse clinical presentation may mimic various endocrine disorders, making the diagnosis challenging in some clinical circumstances. Prolactin (PRL) is a recommended biomarker in the initial diagnostic workup to rule out hyperprolactinemia (HPRL). The traditional role of PRL is linked to lactation and the reproductive system. Recent research highlights PRL’s emerging role in metabolic homeostasis. PRL influences metabolism directly by interacting with the pancreas, liver, hypothalamus, and adipose tissue. Its influence on an individual’s metabolism is intricately tied to its serum concentration. While deficient and very high levels of PRL can negatively affect metabolism, intermediate–normal to moderately high levels may promote metabolic health. In women with PCOS, PRL levels may be altered. Research results on different aspects of the relationship between PCOS and the impact of various levels of PRL on metabolic homeostasis are limited and inconsistent. In this narrative literature review, we comprehensively examined data on serum PRL levels in PCOS patients. We investigated the correlation between a favorable metabolic profile and serum PRL levels in this population. Furthermore, we explored the concept of beneficial PRL effects on metabolism and discussed the potential therapeutic application of dopamine agonists in PCOS treatment. Lastly, we emphasized several promising avenues for future research in this field.

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Section: The Effects Of Prolactin On Metabolismmentioning

confidence: 99%