Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

Wang, Rui; Liu, Hongyan

doi:10.1055/a-1475-4444

Cited by 16 publications

(8 citation statements)

References 33 publications

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“…In addition, serum irisin level has been found to be lower in patients with 1.73 m 2 GFR< 60 mL/ min compared to patients with 1.73 m 2 GFR≥ 60 mL/min (four studies). These studies show that serum irisin level may be associated with albuminuria and decreased GFR in T2DM patients (52). In our study, a negative correlation was found between irisin and GFR.…”

supporting

confidence: 68%

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Döğüş¹,

İçen²,

Kibar³

et al. 2023

JEURMEDS

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Objective: Type 2 diabetes mellitus is a metabolic disease characterized by multi-organ involvement, mostly the renal system, as a result of impaired blood sugar regulation. Damage to the renal system can be serious and can be noticed late. Type 2 diabetes mellitus is associated with adipokine disorders, and irisin molecule, a myokine involved in glucose and lipid metabolism, has also been reported to play a role in the pathogenesis. In this study, it was aimed to compare serum irisin levels between healthy individuals and type 2 diabetes mellitus patients at different stages in terms of nephropathy and to demonstrate that irisin can be a guide in the diagnosis and treatment of the disease in earlier stages before kidney damage develops. Material and Methods:The study included 101 samples of type 2 diabetes mellitus and 28 healthy volunteers who applied to Çukurova University Balcalı Hospital. The participants in the study were divided into five groups in total. The groups consisted of the first group including healthy volunteers without a history of diabetes, and four separate groups of diabetic nephropathy patients, which were formed by considering Mogensen's staging criteria. Serum irisin levels and routine biochemical parameters were also evaluated in the groups. Chi-square and One Way Anova tests were used for statistical analysis to compare group data.Results: Serum irisin level was found to be significantly higher in group 1 (p< 0.001). Especially in group 2 (Mogensen stage 1 hyperfiltration and hypertrophy stage), serum irisin level was found to be significantly lower than the control group (p< 0.001). Hemoglobin A1c, micoralbumin/creatinine and HOMA-IR values were found to be significantly lower in group 1 (p< 0.001 for each). It was determined that irisin had a weak negative correlation between hemoglobin A1c, microalbumin/creatinine and glomerular filtration rate respectively (p= 0.001, r= -0.286), (p= 0.199, r= -0.015), (p= 0.142, r= -0.158), while it had a weak positive correlation between HOMA-IR (p= 0.008, r= 0.308). Conclusion:According to the data obtained from the study, it was thought that serum irisin levels could be used as a guide in the early diagnosis of diabetic nephropathy before the symptoms related to nephropathy appear and the glomerular filtration rate decreases.

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supporting

confidence: 68%

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Döğüş¹,

İçen²,

Kibar³

et al. 2023

JEURMEDS

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“…Plasma irisin levels and muscular FNDC5 expression levels were reduced in patients with obesity and T2DM [47,48]. Moreover, there was an association between serum irisin and diabetic nephropathy in patients with T2DM [49]. Thus, irisin has been linked to favorable effects on metabolic diseases, such as obesity and T2DM [25].…”

Section: Discussionmentioning

confidence: 99%

Pentamethylquercetin Regulates Lipid Metabolism by Modulating Skeletal Muscle-Adipose Tissue Crosstalk in Obese Mice

et al. 2022

Pharmaceutics

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Irisin is an exercise-induced hormone that regulates lipid metabolism. The present study investigates whether the anti-obesity effect of the natural flavonoid pentamethylquercetin (PMQ) is related to irisin secretion from skeletal muscle in whole animals and cultured cells. Obese mice induced by monosodium glutamate were administered oral PMQ to determine blood irisin level and in vivo parameters of lipid metabolism, and cultured mouse C2C12 myoblasts and 3T3-L1 preadipocytes were employed to investigate the related molecular identities. PMQ increased circulating irisin and decreased bodyweight, insulin, and lipid levels accompanied with increasing brown-like adipocyte formation in obese mice. The brown adipocyte marker uncoupling protein 1 (UCP-1) and other brown-like adipocyte-specific genes and/or markers were increased in mouse white fat tissue, while PMQ treatment reversed the above changes. PMQ also dose-dependently increased the reduced levels of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and fibronectin type III domain-containing 5 (FNDC5) signal molecules in obese mice. Interestingly, the irisin level was increased in the culture medium of C2C12 cells treated with PMQ, and the conditioned medium stimulated the brown-like transition of 3T3-L1 preadipocytes with the increased expression of PGC-1α, FNDC5, UCP-1, and other brown-like adipocyte-specific genes. The effects of conditioned culture medium were abolished in C2C12 cells with silenced PGC-1α. On the other hand, PMQ-induced upregulation of PGC-1α and FNDC5 expression was reduced by AMPK inhibitor Compound C in C2C12 cells. Our results demonstrate the novel information that PMQ-induced irisin secretion from skeletal muscle involves the improvement of metabolic dysfunction in obese mice via activating the AMPK/PGC-1α/FNDC5 signal pathway, suggesting that PMQ modulates skeletal muscle-adipose tissue crosstalk and may be a promising drug candidate for treating obesity and obesity-related metabolic diseases.

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“…Additionally, the performed statistical analysis showed that BMI, HbA1c and creatinine were the most strongly and significantly correlated with irisin concentration. Recent studies indicate the presence of a strong association between CKD and lowered irisin levels [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

et al. 2022

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Irisin is a cytokine involved in many metabolic pathways occurring, among others, in muscles, adipose tissue and liver. Thus, fluctuations in irisin levels are suggested to be related to metabolic diseases. Therefore, the purpose of our study was to evaluate whether irisin may be associated with non-alcoholic fatty liver disease (NAFLD). A total of 138 patients (70/68 male/female, mean age 65.61 ± 10.44 years) were enrolled in the study. The patients were assigned to the NAFLD group (n = 72, including 46 patients with type 2 diabetes (T2DM]) and the group without NAFLD (n = 66, 31 patients with T2DM). NAFLD was diagnosed based on ultrasound examination, Hepatic Steatosis Index (HSI) and Fatty Liver Index. Baseline anthropometric, blood pressure and biochemical parameters were collected. The serum irisin level was determined using an ELISA test. We observed that NAFLD was associated with an increased concentration of irisin. Moreover, Spearman correlations and linear regression analysis revealed that irisin level correlates with some anthropometric and biochemical parameters such as body mass index, glycated hemoglobin, aspartic aminotransferase, creatinine and urea. Logistic regression analysis depicted that odds for NAFLD increase 1.17 times for each 1 μg/mL rise of irisin concentration. Finally, ROC analysis showed that the concentration of irisin possesses a discriminate capacity for NAFLD and optimal cut points concentration could be designed. The risk of NAFLD in the subgroup with irisin concentration above 3.235 μg/mL was 4.57 times higher than in patients with the lower concentration of irisin. To conclude, the obtained results suggest that irisin concentration is associated with some anthropometric and biochemical parameters and should be further investigated toward its usage as a diagnostic biomarker of NAFLD.

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Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

Cited by 16 publications

References 33 publications

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Evaluation of Serum Irisin Levels in Patients Developing Nephropathy Due to Type 2 Diabetes Mellitus

Pentamethylquercetin Regulates Lipid Metabolism by Modulating Skeletal Muscle-Adipose Tissue Crosstalk in Obese Mice

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

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