Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

Abstract

Irisin is a cytokine involved in many metabolic pathways occurring, among others, in muscles, adipose tissue and liver. Thus, fluctuations in irisin levels are suggested to be related to metabolic diseases. Therefore, the purpose of our study was to evaluate whether irisin may be associated with non-alcoholic fatty liver disease (NAFLD). A total of 138 patients (70/68 male/female, mean age 65.61 ± 10.44 years) were enrolled in the study. The patients were assigned to the NAFLD group (n = 72, including 46 patients with type 2 diabetes (T2DM]) and the group without NAFLD (n = 66, 31 patients with T2DM). NAFLD was diagnosed based on ultrasound examination, Hepatic Steatosis Index (HSI) and Fatty Liver Index. Baseline anthropometric, blood pressure and biochemical parameters were collected. The serum irisin level was determined using an ELISA test. We observed that NAFLD was associated with an increased concentration of irisin. Moreover, Spearman correlations and linear regression analysis revealed that irisin level correlates with some anthropometric and biochemical parameters such as body mass index, glycated hemoglobin, aspartic aminotransferase, creatinine and urea. Logistic regression analysis depicted that odds for NAFLD increase 1.17 times for each 1 μg/mL rise of irisin concentration. Finally, ROC analysis showed that the concentration of irisin possesses a discriminate capacity for NAFLD and optimal cut points concentration could be designed. The risk of NAFLD in the subgroup with irisin concentration above 3.235 μg/mL was 4.57 times higher than in patients with the lower concentration of irisin. To conclude, the obtained results suggest that irisin concentration is associated with some anthropometric and biochemical parameters and should be further investigated toward its usage as a diagnostic biomarker of NAFLD.

A Machine Learning-Based Method for Detecting Liver Fibrosis

“…As the gallbladder mucosa has its role in insulin regulation, cholecystectomy is associated with increased manifestations of IR due to dysregulation of these mechanisms. This has been shown in some studies, where people after cholecystectomy have an increase in fat levels, apolipoprotein B, insulin and in the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index [64,69]. The worsening of metabolic syndrome is linked to an aggravation of the MASLD condition and a high risk of progression in hepatic fibrosis.…”

Exploring the interconnected between type 2 diabetes mellitus and nonalcoholic fatty liver disease: Genetic correlation and Mendelian randomization analysis

“…However, many factors are also involved in their development. These include genetic predispositions, [31,32] environmental and lifestyle influences, [33] intestinal microbiome alterations, [34,35] IR, [36] and disturbances in lipid and glucose metabolisms. [37] The development of NAFLD is strongly associated with hepatic IR.…”

Protective effect of Lactiplantibacillus plantarum CCFM8661 against heavy metal mixture-induced liver and kidney injury in mice

“…CAT is an important antioxidant enzyme in the body that reduces oxidative stress in tissues by breaking down hydrogen peroxide into water and oxygen. 16 The effects of L. plantarum CCFM8661 on CAT activity in the liver and kidney tissues of mice are shown in Fig. 3b and 4b.…”