Association Between Serum 25-Hydroxy Vitamin D Levels and Blood Pressure Among Adolescents in Two Resource-Limited Settings in Peru

Tomaino, Katherine; Romero, Karina; Robinson, Courtland; Baumann, Lauren; Hansel, Nadia N.; Pollard, Suzanne L.; Gilman, Robert H.; Mougey, Edward B.; Lima, John J.; investigators, Pura study

doi:10.1093/ajh/hpu264

Cited by 22 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many observational studies have reported an inverse association between low VitD levels and brachial BP in large samples from the general population [23,24,25], but also among Peruvian adolescents [26], middle-aged individuals [27], people aged >60 years and the elderly [28,29], pregnant women and women aged 20-80 years [30,31]. Similarly, the evidence from medium to large observational studies shows strong and independent inverse associations between serum VitD and cfPWV among diverse study populations [32,33,34,35,36,37,38].…”

Section: Summary Of Observational Data On the Relationship Between Sementioning

confidence: 99%

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Veloudi

Jones

Sharman³

2016

Pulse

View full text Add to dashboard Cite

There is a plausible physiological theory, supported by many observational studies, that vitamin D supplementation should be effective for improving cardiovascular end points, such as blood pressure (BP), large artery stiffness, atherosclerosis, endothelial function and clinical events. However, results from randomised controlled trials (RCTs) have been inconsistent. In this review, we evaluated the evidence regarding the effectiveness of vitamin D supplementation for cardiovascular surrogate and hard clinical end points. RCTs were assessed in terms of sample size, duration of supplementation, baseline vitamin D level inclusion criteria (i.e., absence of vitamin D deficiency), dosage of vitamin D and population under investigation. Forty-five RCTs were identified. Eight RCTs with BP and 6 RCTs with large artery stiffness as the end points were found to comply with guidelines for the optimal design of clinical trials evaluating nutrient effects. Only 2 of the RCTs with an optimal design were effective in decreasing BP with vitamin D supplementation, although these were of moderate sample size (<150) and very short duration (8 weeks for both), whilst no RCT was effective in reducing large artery stiffness. Similar results were observed for atherosclerotic and endothelial function markers as end points. Only 1 RCT reported cardiovascular events as an end point and found neither increased nor decreased incident cardiovascular events over 7 years of follow-up. In conclusion, results from published RCTs indicate that vitamin D supplementation is ineffective in improving cardiovascular health among various patient populations, including in the presence or absence of vitamin D deficiency.

show abstract

Section: Summary Of Observational Data On the Relationship Between Sementioning

confidence: 99%

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Veloudi

Jones

Sharman³

2016

Pulse

View full text Add to dashboard Cite

show abstract

“…Additionally, a cross-sectional analysis of 1460 participants in Shanghai showed high prevalence of vitamin D deficiency (55.8%) in middle-aged and elderly Chinese men [ 75 ]. In adolescents (aged 13–15), a study of 1441 Peruvians showed an inverse association between vitamin D deficiency and blood pressure, which may predispose risk of HTN later in adulthood [ 76 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and risk of cardiovascular diseases: a narrative review

et al. 2018

View full text Add to dashboard Cite

Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). It plays a major role in bones and calcium metabolism. Vitamin D deficiency is not uncommon and it has been associated with many health-related issues, including skeletal and non-skeletal complications. The association of low vitamin D and cardiovascular diseases and risk factors has been explored in both animal and human studies. However, studies and trials on the effect of vitamin D supplementation on cardiovascular risk factors and hypertension are conflicting with inconsistent results. Therefore, large, well-powered randomized controlled trials are warranted. If successful, supplementation with easy and low-cost vitamin D can impact our health positively. Here, we summarized the evidence for the association of vitamin D, cardiovascular diseases and risk factors, including coronary artery diseases, stroke, and hypertension, and mortality, with special consideration to resistant hypertension.

show abstract

“…In this study, diastolic blood pressure was higher in the 25(OH)D 3 -deficient group than the 25(OH)D 3 -sufficient group ( P = 0.04). [ 10 ] Pacifico et al . similarly concluded that with increasing serum 25(OH)D 3 levels, there was a significant decrease in median systolic and diastolic blood pressure values.…”

Section: Itamin D and The H mentioning

confidence: 99%

Vitamin D and Cardiovascular Risk in Children

Jin

2017

Chinese Medical Journal

View full text Add to dashboard Cite

Objective:Vitamin D is a group of fat-soluble molecules that are structurally similar to steroids. Emerging data have led to the hypothesis that Vitamin D plays a role in the regulation of many physiological processes beyond calcium and phosphorus homeostasis. With this review, we aimed to summarize the changes in Vitamin D levels in children with cardiovascular diseases based on the literature. In addition, we also reviewed the potential mechanisms underlying cardiovascular diseases associated with Vitamin D deficiency or insufficiency.Data Sources:The articles in English were searched from PubMed (1968–2016) and EMBASE (1991–2016), with the keywords of “Vitamin D AND cardiovascular diseases” and “Vitamin D AND children.”Study Selection:Original articles and critical reviews about Vitamin D and cardiovascular risk in children were selected for review. Researches focused on adults were excluded.Results:Studies have shown that several pediatric cardiovascular diseases may be associated with Vitamin D deficiency or insufficiency, including hypertension, orthostatic intolerance, and Kawasaki disease.Conclusions:Vitamin D may play a role in the regulation of the cardiovascular system. Further investigation would hopefully disclose the usefulness of Vitamin D as a biomarker for cardiovascular diseases in children.

show abstract

Association Between Serum 25-Hydroxy Vitamin D Levels and Blood Pressure Among Adolescents in Two Resource-Limited Settings in Peru

Abstract: Adolescents deficient in 25OHD demonstrated increased DBP and MAP and a trend toward increased SBP, when compared to nondeficient subjects. 25OHD deficiency early in life was associated with elevated BP metrics, which may predispose risk of hypertension later in adulthood.

Cited by 22 publications

References 33 publications

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes

Vitamin D deficiency and risk of cardiovascular diseases: a narrative review

Vitamin D and Cardiovascular Risk in Children

Contact Info

Product

Resources

About