Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study

Little, Keriann; Olsson, Craig A.; Whittle, Sarah; Youssef, George; Byrne, Marann; Simmons, Julian G; Yücel, Murat; Foley, Debra L.; Allen, Nicholas B.

doi:10.1038/tp.2014.85

Cited by 25 publications

(17 citation statements)

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“…Accordingly, the right hippocampus is important to the curtailment of stress responses (16,34), and fear extinction (35). Furthermore, smaller left hippocampal volume is a risk for the association between recent life stress and the development of anxiety symptoms (36) and onset of major depression (37). Likewise, a recent metaanalysis demonstrates that left hippocampal volume is associated with posttraumatic stress disorder (PTSD) (38).…”

Section: This Article Is a Pnas Direct Submissionmentioning

confidence: 99%

An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior

Rifkin‐Graboi

Tan

Yew

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Attachment disorganization is a risk factor for difficulties in attention, social relationships, and mental health. Conceptually, attachment disorganization may indicate a breakdown in fear regulation resulting from repeated exposure to frightening maternal care. In addition, past research has examined the influence of stress-inducing contextual factors and/or child factors upon the development of disorganization. However, no past work has assessed whether infant neuroanatomy, important to stress regulation, moderates the association between maternal care and levels of disorganized behavior. Here, utilizing data from a subsample of 82 dyads taking part in the “Growing Up in Singapore towards Healthy Outcomes” (GUSTO) cohort, we assessed the prediction from maternal sensitive caregiving at 6 mo and levels of attachment disorganization at 1.5 y, as moderated by hippocampal and amygdala volume determined within the first 2 weeks of life. Results indicate a significant interaction between neonatal left hippocampal volume and maternal sensitivity upon levels of disorganized behavior. Although these results require substantiation in further research, if replicated, they may enable new strategies for the identification of processes important to child mental health and points for intervention. This is because neonatal neuroanatomy, as opposed to genetic variation and sociodemographic risk, may be more directly linked to stress responses within individuals.

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Section: This Article Is a Pnas Direct Submissionmentioning

confidence: 99%

An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior

Rifkin‐Graboi

Tan

Yew

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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“…Furthermore, MDD is associated with atypicalities in the neural circuits that are implicated in ToM decoding and that are heavily innervated by dopamine and serotonin [ 26 ]. For example, MDD patients, and those at risk by virtue of being s-allele carriers of the 5-HTTLPR, show lower amygdala and orbitofrontal cortical volumes than healthy individuals and those not at risk [ 27 , 28 ]. Further, the effect of the s-allele of the 5-HTTLPR on amygdala responses to valenced social stimuli is stronger in MDD patients than controls [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation

et al. 2016

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Theory of mind–the ability to decode and reason about others’ mental states–is a universal human skill and forms the basis of social cognition. Theory of mind accuracy is impaired in clinical conditions evidencing social impairment, including major depressive disorder. The current study is a preliminary investigation of the association of polymorphisms of the serotonin transporter (SLC6A4), dopamine transporter (DAT1), dopamine receptor D4 (DRD4), and catechol-O-methyl transferase (COMT) genes with theory of mind decoding in a sample of adults with major depression. Ninety-six young adults (38 depressed, 58 non-depressed) completed the ‘Reading the Mind in the Eyes task’ and a non-mentalistic control task. Genetic associations were only found for the depressed group. Specifically, superior accuracy in decoding mental states of a positive valence was seen in those homozygous for the long allele of the serotonin transporter gene, 9-allele carriers of DAT1, and long-allele carriers of DRD4. In contrast, superior accuracy in decoding mental states of a negative valence was seen in short-allele carriers of the serotonin transporter gene and 10/10 homozygotes of DAT1. Results are discussed in terms of their implications for integrating social cognitive and neurobiological models of etiology in major depression.

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“…Full-length articles of screening studies, studies in non-adolescents or with a mixed sample with the age beyond the range of 10–19 years for adolescents or 20–25 years for young adults, studies with only the mean age, studies without clearly identified gene expression or polymorphism, or others was excluded from the analysis. Finally, 47 full-length articles (Eley et al, 2004 ; Mamalakis et al, 2004 ; Burcescu et al, 2005 ; Miraglia del Giudice et al, 2006 ; Sjöberg et al, 2006 ; Geng et al, 2007 ; Hilt et al, 2007 ; Pandey et al, 2007 , 2012 ; Feng et al, 2008 ; Aslund et al, 2009 ; Duncan et al, 2009 ; Goodyer et al, 2009 , 2010 ; Guo and Tillman, 2009 ; Laucht et al, 2009 ; Nilsson et al, 2009 ; Nobile et al, 2009 ; Benjet et al, 2010 ; Brent et al, 2010 ; Mata et al, 2010 ; Nederhof et al, 2010 ; Uddin et al, 2010 , 2011 ; Bouma et al, 2011 ; Hankin et al, 2011 ; Jenness et al, 2011 ; Mata and Gotlib, 2011 ; Thompson et al, 2011 ; Chen et al, 2012 , 2013 ; Petersen et al, 2012 ; Buchmann et al, 2013 ; Bobadilla et al, 2013 ; Comasco et al, 2013 ; Cutuli et al, 2013 ; Kohen et al, 2013 ; Otten and Engels, 2013 ; Oppenheimer et al, 2013 ; Priess-Groben and Hyde, 2013 ; Stavrakakis et al, 2013 ; Banducci et al, 2014 ; Cicchetti and Rogosch, 2014 ; Cruz-Fuentes et al, 2014 ; Little et al, 2014 ; Zhang et al, 2015 ) in adolescents and three studies (Hammen et al, 2010 ; Starr et al, 2013 ; Thompson et al, 2014 ) in young adults were included in this study (Figure 1 ). The 47 studies in adolescence included 20 genes or gene families while the three studies in young adults included three genes (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

The Involvement of Genes in Adolescent Depression: A Systematic Review

Xia

Yao

2015

Front. Behav. Neurosci.

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Numerous studies have reported on the roles of genetic factors in the development of depression in adolescents and young adults. However, there are few systematic reviews that update our understanding of adolescent depression with the biological findings identifying the roles of gene expression and/or polymorphism(s). This review systematically summarized the findings that clearly identified the contribution of a gene to the risk of depression in adolescents between the ages of 10 and 19 years old and young adults between the ages of 20 and 25 years old. Data were obtained through searching PubMed, Embase, and Web of Science. A total of 47 studies on early adolescence and three studies on young adults were included in the current review. Most articles studied genes in the serotonergic system (n = 26), dopaminergic system (n = 3), and the Brain-derived neurotropic factor (BDNF) gene (n = 12). 92.3% of studies (24/26) identified positive associations of 5-HTTLPR polymorphism with depressive illness or depressive symptoms. 83.3% of studies (10/12) found positive association between BDNF Val66Met genotype and adolescent depressive symptoms. More studies should be conducted on the 18 genes reported in a few studies to clarify their roles in the risk for adolescent depression.

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Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study

Cited by 25 publications

References 100 publications

An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior

An initial investigation of neonatal neuroanatomy, caregiving, and levels of disorganized behavior

Serotonin and Dopamine Gene Variation and Theory of Mind Decoding Accuracy in Major Depression: A Preliminary Investigation

The Involvement of Genes in Adolescent Depression: A Systematic Review

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