Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease

Liu, Yijia; Ma, Mei; Li, Lin; Liu, Fanfan; Li, Zhu; Yu, Lu; Yang, Tong; Wang, Yan; Gao, Shan; Gao, Sheng; Yang, Ruijie; Yu, Chunquan

doi:10.1007/s12020-022-03254-x

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…Hepatic insulin resistance is also caused by acutely elevated plasma FFA [53]. A signi cant association between impaired sensitivity to thyroid hormones and elevated triglycerides was found [54]. Therefore, we induced that impaired sensitivity to thyroid hormones may have a link with IR through disordered blood lipid metabolism.…”

Section: Discussionmentioning

confidence: 88%

Impaired Sensitivity to Thyroid Hormones is Associated with High Insulin Resistance Levels in the Euthyroid Chinese Population

Cui,

Wei,

Liu

et al. 2023

Preprint

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Background: The association between thyroid hormones sensitivity and insulin resistance (IR) remains unknown. This study was designed to analyze the relationship between sensitivity to thyroid hormones and IR stratified by different levels of obesity. Methods: 32478 euthyroid participants were included and they were divided into three groups according to the body mass index (BMI): normal weight (n=20200), overweight (n=10178) and obesity (n=2100). We used The Thyroid Feedback Quantile-based Index (TFQI), The TSH Index (TSHI), the Thyrotrophic T4 Resistance Index (TT4RI) to represent thyroid hormones sensitivity and used Triglyceride-Glucose (TyG) Index, the Atherogenic Index of Plasma (AIP), The Metabolic Score for Insulin Resistance (METS-IR) to represent IR. The association between thyroid hormones sensitivity and IR were analyzed by linear regression and logistic regression. Results: Linear regression analysis revealed that TFQI, TSHI and TT4RI were positively associated with TyG, AIP and METS-IR. Logistic regression showed that in the normal weight group, the odds ratios (ORs) for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.430 (95% CI: 1.288,1.587); 1.537 (95% CI: 1.388,1.703); 1.518 (95% CI: 1.370,1.682) respectively (all p<0.001) compared with the lowest quartiles of the TFQI, TSHI, and TT4RI; In the overweight group, the ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.269 (95% CI:1.104,1.459); 1.363 (95% CI:1.186,1.566); 1.353 (95% CI:1.177,1.555) respectively (all p< 0.001); In the obesity group, the ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.298 (95% CI:0.951,1.774) (p=0.101); 1.454 (95% CI:1.065,1.989) (p=0.05); 1.455 (95% CI:1.066,1.991) (p=0.05) respectively. AIP and METS-IR yielded roughly similar results. Conclusion: In euthyroid adults, reduced sensitivity to thyroid hormones was associated with high levels of IR. Our study provides insight for further exploring the pathogenesis of metabolic syndrome as well as guidance for its treatment.

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Section: Discussionmentioning

confidence: 88%

Impaired Sensitivity to Thyroid Hormones is Associated with High Insulin Resistance Levels in the Euthyroid Chinese Population

Cui,

Wei,

Liu

et al. 2023

Preprint

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“…Both TFQI and PTFQI measures account for outlier values in the presence of thyroid dysfunction and have been linked to diabetes, metabolic disease, and dyslipidemia in multiple investigations ( 20 , 22 , 46 ). Only a few cross-sectional studies have explored relationships between indices of pituitary sensitivity to thyroid hormones with BP and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Thyroid-related Hormones and Hypertension Incidence in Middle-Aged and Older Hispanic/Latino Adults: The HCHS/SOL Study

Abasilim,

Persky,

Sargis

et al. 2024

Journal of the Endocrine Society

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Background Thyroid-related hormones act to regulate metabolic pathways and blood pressure (BP). However, the relationship of thyroid stimulating hormone (TSH), peripheral thyroid hormones, and the role of the hypothalamic-pituitary-thyroid axis on hypertension development is not fully understood. We assessed sex-specific associations of thyroid-related hormones with BP and hypertension in Hispanic/Latino adults followed for 6 years. Methods We studied 1,789 adults, aged 45-74, free of diabetes at baseline from a subcohort of the Hispanic Community Health Study/Study of Latinos. We assessed TSH, free-thyroxine (FT4), triiodothyronine (T3), and various indicators of thyroid axis. Using multivariable linear and Poisson regression adjusted for survey design and confounding variables, we estimated a priori sex-specific associations of thyroid-related hormones with change in BP and hypertension development. Results In men and women, TSH and TSH/FT4 ratio were associated with change in diastolic-BP and T3 with change in pulse-pressure and the development of hypertension from prehypertension. . In men, 1-SD increase in TSH (Incident-Rate-Ratio(IRR)=1.42; 95%CI: 1.15,1.75) and TSH/FT4 ratio (IRR=1.20; 95%CI: 1.07,1.35) were positively associated with the development of hypertension from prehypertension while TSH/FT4 ratio (IRR=0.85; 95%CI: 0.72,1.00) was protective in women. We observed sex-specific differences in associations of T3/FT4 ratio, and indices of pituitary sensitivity to thyroid hormones with change in pulse-pressure and hypertension development. Conclusion Thyroid-related hormones are associated with sex-specific changes in BP and hypertension among Hispanic/Latino adults consistent with selected studies conducted in other populations. Mechanisms underlying associations of pituitary sensitivity to thyroid hormones with BP and hypertension development warrant further study.

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“…TT4RI, TSHI and TFQI have been considered to be a reliable surrogate of central sensitivity to thyroid hormones, while FT3/FT4 ratio has been proposed as a surrogate marker of peripheral sensitivity to thyroid hormones in many studies. Currently, a large multicenter retrospective study indicated that high levels of TT4RI, TSHI and TFQI increased risk of dyslipidemia, while high levels of FT3/FT4 decreased risk of dyslipidemia in patients with coronary heart disease (14). In addition, high levels of RC could be corrected by T4 replacement therapy (29).…”

Section: Discussionmentioning

confidence: 99%

“…The normal ranges of FT3, FT4, and TSH in our hospital were 3.10-6.80 pmol/L, 12.00-22.00 pmol/L, and 0.27-4.20 mU/L, respectively. The calculation formulas of TFQI, TT4RI, and TSHI were referred to previous studies [13][14]. The last visit in this study was the incident high RC levels or the last available visit for participants who did not develop incident high RC levels.…”

Section: Data Collection and De Nitionmentioning

confidence: 99%

“…A recent cohort study supported that serum RC levels were positively correlated with TFQI, TSHI, and TT4RI, while negatively correlated with FT3/FT4 ratio levels in Chinese euthyroid adults (13). A subsequent study further study which was conducted in patients with coronary heart disease con rmed the association of sensitivity to thyroid hormones with dyslipidemia (14). However, the above two studies were conducted with a crosssectional study design.…”

Section: Introductionmentioning

confidence: 97%

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Gender difference in the association between sensitivity to thyroid hormones with incident high remnant cholesterol levels in euthyroid adults

Guo

Lü

et al. 2023

Preprint

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Background Whether resistance to thyroid hormones affect the atherogenic remnant cholesterol (RC) levels remains unknown. The aim of this study was to explore the association of sensitivity to thyroid hormones with the incident high RC levels in euthyroid Chinese adults and further explore this association was modified by gender differences. Methods We performed a post hoc analysis including eligible participants from the 11223 who underwent at least two health examinations and were with RC < 0.8 at baseline from 2006 to 2010. Central and peripheral sensitivity to thyroid hormones such as thyroid-stimulating hormone index (TSHI) and thyrotrophic thyroxine resistance index (TT4RI), thyroid feedback quantile-based index (TFQI) and free triiodothyronine (FT3)/free thyroxine (FT4) were calculated. Results Participants with RC levels had higher levels of TSHI ,TT4RI and TFQI than participants in the normal RC group in females. However, there were no differences of TSHI, TT4RI, TFQI and FT3/FT4 between the normal RC group and the high RC group in males. In the multi-adjusted models, the highest tertiles (tertiles 3) of TSHI was associated with an increased high RC levels risk compared with the lowest tertiles (tertiles 1) (HR = 1.819, 95%CI 1.268–2.607, P = 0.001) in females. The association was also significant using TT4RI and TFQI as indices of central sensitivity to thyroid hormones in females. In stratified analyses, the relationship between thyroid hormone sensitivity and incident high RC levels was statistically significant in women < 48 years old, but not in ≥ 48 years old. Conclusion High TSHI ,TT4RI and TFQI increase risk of incident high RC levels in euthyroid Chinese adults in females, suggesting that central resistance of thyroid hormones may participant in the pathophysiological process of high RC levels.

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Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease

Cited by 5 publications

References 54 publications

Impaired Sensitivity to Thyroid Hormones is Associated with High Insulin Resistance Levels in the Euthyroid Chinese Population

Impaired Sensitivity to Thyroid Hormones is Associated with High Insulin Resistance Levels in the Euthyroid Chinese Population

Thyroid-related Hormones and Hypertension Incidence in Middle-Aged and Older Hispanic/Latino Adults: The HCHS/SOL Study

Gender difference in the association between sensitivity to thyroid hormones with incident high remnant cholesterol levels in euthyroid adults

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