Association between selenium nutritional status and metabolic risk factors in men with visceral obesity

Mutakin,; Meiliana, Anna; Wijaya, Andi; Kobayashi, Kenji; Yamazaki, Chiho; Kameo, Satomi; Nakazawa, Minato; Koyama, Hiroshi

doi:10.1016/j.jtemb.2012.09.006

Cited by 24 publications

(13 citation statements)

References 36 publications

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“…Many animal experiments and clinical studies had indicated that Se plays an important role in diverse physiologic actions [1,2]. The essentiality of Se depends on its role at the catalytic site of multiple selenoproteins [3].…”

Section: Introductionmentioning

confidence: 99%

Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine

Yan

Ruan

et al. 2014

Nanoscale Res Lett

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The study was designed to determine the differential protein expression of Caco-2 cells treated with different forms of selenium including sodium selenite, selenomethionine (Se-Met), and selenium nanoparticles (nano-Se). Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass spectrometry (MS) were used to identify the differentially expressed proteins. The results indicated that seven protein spots, ubiquitin-conjugating enzyme E2 (E2), glutathione synthetases (GS), triosephosphate isomerase (TSP), T-complex protein 1 subunit zeta (TCPZ), lamin-B1, heterogeneous nuclear ribonucleoprotein F (hnRNP F), and superoxide dismutase [Cu-Zn] (Cu, Zn-SOD) were significantly different among all the groups. According to the order of control, sodium selenite, Se-Met, and Nano-Se, the expression levels of two proteins (E2 and GS) increased and the other differential proteins were reverse. Except for E2, there were no significant differences in other protein expressions between the groups treated with nano-Se and Se-Met.

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Section: Introductionmentioning

confidence: 99%

Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine

Yan

Ruan

et al. 2014

Nanoscale Res Lett

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“…Superoxide anion is dismutated by superoxide dismutase and as a result, hydrogen peroxide is produced, the latter, is converted to water by the anti-oxidative activity of glutathione peroxidase. Lower SOD and GPx activities have been reported in obese and overweight women and men with metabolic syndrome without diabetes compared to normal weight controls [32,33]. Furthermore, others have reported lower levels in patients with diabetes compared to non-diabetic control subjects, the magnitude of which was greater in the presence of obesity [34].…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, from the above-mentioned studies [5,[32][33][34], it is apparent that there is an increased oxidative stress in the presence of obesity as a result of diminished antioxidant enzyme activities. On the other hand, there is a paradox with the current study that women have increased GPx-3 activity even though they have an increase in central obesity.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Glutathione Peroxidase Activity and Central Obesity in Patients with Type 2 Diabetes at High Risk of Cardio-Renal Disease

et al. 2019

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Women with type 2 diabetes (T2DM) have an increased susceptibility of developing cardio-renal disease compared to men, the reasons and the mechanisms of this vulnerability are unclear. Since oxidative stress plays a key role in the development of cardio-renal disease, we investigated the relationship between sex, plasma antioxidants status (glutathione peroxidase (GPx-3 activity), vitamin E and selenium), and adiposity in patients with T2DM at high risk of cardio-renal disease. Women compared to men had higher GPx-3 activity (p = 0.02), bio-impedance (p ≤ 0.0001), and an increase in waist circumference in relation to recommended cut off-points (p = 0.0001). Waist circumference and BMI were negatively correlated with GPx-3 activity (p ≤ 0.05 and p ≤ 0.01, respectively) and selenium concentration (p ≤ 0.01 and p ≤ 0.02, respectively). In multiple regression analysis, waist circumference and sex were independent predictors of GPx-3 activity (p ≤ 0.05 and p ≤ 0.05, respectively). The data suggest that increased central fat deposits are associated with reduced plasma antioxidants which could contribute to the future risk of cardio-renal disease. The increased GPx-3 activity in women could represent a preserved response to the disproportionate increase in visceral fat. Future studies should be aimed at evaluating if the modulation of GPx-3 activity reduces cardio-renal risk in men and women with T2DM.

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“…22 In a study examining the association between Se status and metabolic risk factors in men with visceral obesity, Se was positively correlated with high-density lipoprotein (HDL) and fatty acid binding protein-4, (FABP4), while GPX3 activity was negatively correlated with FABP4. 23 In obese men who had at least one component of the metabolic syndrome (MS), GPX3 activity was positively correlated with HDL. These findings indicate that Se status is linked to metabolic risk factors only in particular groups of obese men with or without MS. 22 This partially accords with recent animal studies suggesting a risk that long-term high Se intake could induce insulin resistance and T2DM.…”

Section: Selenium Obesity and Diabetesmentioning

confidence: 99%

Selenium and Inflammation— Potential Use and Future Perspectives

Duntas¹,

Hubalewska‐Dydejczyk²

2015

US Endocrinology

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The essential trace element selenium (Se) is constitutively incorporated as selenocysteine, in proteins, among others in antioxidative selenoproteins, such as glutathione peroxidase(s) and thioredoxin reductase. Since chronic inflammation is thought to deplete Se stores in the body, Se supplementation should be considered in prolonged inflammatory states, Se being the trace element the most affected in chronic or low-grade inflammation. Se administration might also be beneficial in bacterial and viral diseases as well as metabolic and autoimmune diseases. In order to maintain a Se steady state, or “selenostasis,” Se supplementation, via either diet or compounds, is required to preserve the activity of selenoproteins in antioxidative and redox processes. Importantly, Se could play a pivotal role in the maintenance of homeostasis in infected tissues by inhibiting the proinflammatory toll-like receptor nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway and counteracting proinflammatory cytokine action. Finally, while Se status shows considerable promise as a valid marker of inflammatory and autoimmune disease, new functional Se nanoparticles and highly bioavailable selenomethionine compounds will in all probability provide a more efficacious and reliable intervention tool in both preventive and therapeutic disease management.

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Association between selenium nutritional status and metabolic risk factors in men with visceral obesity

Cited by 24 publications

References 36 publications

Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine

Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine

Sex Differences in Glutathione Peroxidase Activity and Central Obesity in Patients with Type 2 Diabetes at High Risk of Cardio-Renal Disease

Selenium and Inflammation— Potential Use and Future Perspectives

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