Association between Sarcopenia and Renal Function in Patients with Diabetes: A Systematic Review and Meta-Analysis

Ida, Satoshi; Kaneko, Ryutaro; Imataka, Kanako; Murata, Kazuya

doi:10.1155/2019/1365189

Cited by 28 publications

(29 citation statements)

References 41 publications

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“…In the present study, the risk of albuminuria was the highest in the patients with sarcopenic obesity. Previous studies showed that both sarcopenia and obesity were the risk of macroalbuminuria [15][16][17]. On the other hand, in this study, we revealed Since the cases of macroalbuminuria is not enough.…”

Section: Discussioncontrasting

confidence: 53%

“…Sarcopenia has been established as a risk factor for CVD and mortality [3][4][5]. Additionally, it is known to be a risk of albuminuria [15,16]. Sarcopenic obesity, which more likely causes lifestyle-related morbidities than obesity without sarcopenia, may lead to a further reduction in mobility and is associated with higher mortality rates than sarcopenia alone [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…albuminuria, is an independent risk factor not only for incident ESRD, [11][12][13] but also for mortality [14], particularly in patients with diabetes. Recent studies have showed that sarcopenia is associated with the risk of albuminuria in patients with T2DM [15,16], and obesity is a risk factor for proteinuria [17]. Thus, there is a possibility that sarcopenic obesity is associated with albuminuria in patients with T2DM.…”

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confidence: 99%

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Sarcopenic obesity is associated with macroalbuminuria in patients with type 2 diabetes: a cross-sectional study

et al. 2021

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Sarcopenia is associated with the risk of albuminuria in patients with type 2 diabetes mellitus (T2DM), and obesity is a risk factor for proteinuria. However, the association between sarcopenic obesity and diabetic nephropathy, including albuminuria, in patients with T2DM has not been reported. The study included 206 men and 163 women with T2DM who participated in the KAMOGAWA-DM cohort, which investigating the natural history of diabetes since 2014. Sarcopenia was defined as having both low skeletal muscle mass index (SMI, kg/m 2) (<7.0 kg/m 2 for men and <5.7 kg/m 2 for women) and low handgrip strength (<28 kg for men and <18 kg for women). Obesity was diagnosed by the percentage of body fat (>30% for men and >35% for women). The patient was said to have sarcopenic obesity if he/she had both sarcopenia and obesity. Urinary albumin excretion of patients with sarcopenic obesity was higher than that of patients without sarcopenic obesity (median [interquartile range]: 342.0 [41.8-467.5] vs. 21.0 [9.0-75.4] mg/g Cr, p = 0.016). Additionally, sarcopenic obesity was associated with the presence of macroalbuminuria, compared with non-sarcopenic obesity (adjusted odds ratio 6.92 [95% confidence interval:1.63-29.4], p = 0.009). Adjusted odds ratios of sarcopenic obesity, sarcopenia only, and obesity only for the presence of macroalbuminuria were 6.52 (1.47-28.8, p = 0.014), 1.29 (0.45-3.71, p = 0.638), and 0.78 (0.38-1.58, p = 0.482), respectively, compared with neither sarcopenia nor obesity. This study indicated that sarcopenic obesity is associated with albuminuria, especially macroalbuminuria, in Japanese patients with T2DM.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Sarcopenic obesity is associated with macroalbuminuria in patients with type 2 diabetes: a cross-sectional study

et al. 2021

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“…Then, we chose the newest meta‐analysis with the largest number of studies. Finally, 54 health‐related outcomes extracted from 30 meta‐analyses 10,22‐50 were reported in this umbrella review. These 54 outcomes were mainly about prognostic outcomes of tumor, postoperative outcomes, age‐related outcomes, metabolic outcomes, and other outcomes.…”

Section: Resultsmentioning

confidence: 99%

Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

et al. 2020

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Objective The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health‐related outcomes. Design An umbrella review of meta‐analyses of observational studies. Setting and Participants Patients with sarcopenia and controls without sarcopenia were included. Measures The PubMed, Web of Science and Embase were searched for relevant systematic review and meta‐analysis. AMSTAR and GRADE system were used for methodological quality and evidence quality assessments, respectively. Results Totally 54 outcomes extracted from 30 meta‐analyses were analyzed. Twenty out of 21 prognostic outcomes indicated that sarcopenia was significantly associated with poorer prognosis of gastric cancer, hepatocellular cancer, urothelial cancer, head and neck cancer, hematological malignancy, pancreatic cancer, breast cancer, colorectal cancer, lung cancer, esophageal cancer, and ovarian cancer. Besides, 10 out of 16 postoperative outcomes suggested that sarcopenia significantly increased the risk of multiple postoperative complications and prolonged the length of hospitalization of patients with digestive cancer. In age‐related outcomes, sarcopenia significantly increased the risk of dysphagia, cognitive impairment, fractures, falls, hospitalization, and all‐cause mortality of elderly populations. Moreover, sarcopenia was also associated with higher level of albuminuria, risk of depression, and several metabolic diseases. Conclusions and Implications Sarcopenia significantly affected a wide range of adverse health‐related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as “low” and “very low,” more prospective cohort studies are required in the future.

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“…Despite playing a major role in systemic homeostasis, skeletal muscle size and strength both decrease with age [3,4]. This age-related loss of muscle mass and muscle strength, called sarcopenia, is related to a wide range of chronic disorders [5][6][7][8], motor disorders [9,10], and mortality [11]. Because of this, sarcopenia is a primary therapeutic target for improving the effects of aging in the elderly, and it has been reported that exercise intervention, especially involving resistance training, is a key approach for preventing and improving sarcopenia [12,13].…”

Section: Introductionmentioning

confidence: 99%

Serum Albumin Levels as a Predictive Biomarker for Low-Load Resistance Training Programs’ Effects on Muscle Thickness in the Community-Dwelling Elderly Japanese Population: Results From the Interventional Study

Sawada¹,

Ozaki²,

Natsume³

et al. 2021

Preprint

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Background Resistance training has been recommended as an effective measure against age-related loss of muscle mass and muscle strength, called sarcopenia, even in older adults. However, despite subjecting each participant to the same training program, the training effect solely depended on the individual. This study aimed to evaluate whether certain blood parameters influenced the effect of a low-load resistance training program on muscle thickness in the community-dwelling elderly population.Methods Sixty-nine community-dwelling Japanese (49 women and 20 men) subjects aged 69.4±6.5 years were included. Low-load resistance training was performed twice a week for 12 weeks. Muscle thickness at the anterior aspects of the thigh (AT) was measured using a B-mode ultrasound device, and 22 blood parameter levels were assessed before and after the program. We checked the first quartile value of each parameter to establish cutoff values, and participants were divided into low or normal groups for each parameter.Results A low-load resistance training program significantly increased muscle thickness at the AT. The interaction between time and groups was examined at low (<4.1 g/dL) versus normal (≥4.1 g/dL) serum albumin (Alb) levels. Although there was no difference in muscle thickness at the AT before the training intervention, the hypertrophic effects were higher in the normal serum Alb level group than in the low serum Alb level group. The binomial logistic regression analysis showed that participants in the low serum Alb group had an odds ratio of 7.08 for decreased muscle thickness at the AT. The effect of a low-load resistance training program on lower limb muscle thickness appears to be limited in participants with low serum Alb levels before training interventions.Conclusions Serum Alb level may act as a biomarker to predict the effects of low-load resistance training programs on muscle hypertrophy in elderly individuals.Trial registration This study was retrospectively registered in UMIN-Clinical Trial Registry (CTR), ID: UMIN000042759. Date of registration: 14/12/2020.

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Association between Sarcopenia and Renal Function in Patients with Diabetes: A Systematic Review and Meta-Analysis

Cited by 28 publications

References 41 publications

Sarcopenic obesity is associated with macroalbuminuria in patients with type 2 diabetes: a cross-sectional study

Sarcopenic obesity is associated with macroalbuminuria in patients with type 2 diabetes: a cross-sectional study

Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

Serum Albumin Levels as a Predictive Biomarker for Low-Load Resistance Training Programs’ Effects on Muscle Thickness in the Community-Dwelling Elderly Japanese Population: Results From the Interventional Study

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