Association between Sarcopenia and Metabolic Syndrome in Chronic Obstructive Pulmonary Disease: The Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011

Chung, Jae Ho; Hwang, Heejin; Han, Chang Hoon; Son, Bong Soo; Kim, Do-Hyung; Park, Moo Suk

doi:10.3109/15412555.2014.908835

Cited by 37 publications

(40 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COPD patients were significantly older, had a significantly lower BMI and were more often males (data not shown). As presented in Figure 2, a higher prevalence of MetS among COPD patients compared to controls was found in 9 out of 10 studies (23,25,30,34,(36)(37)(38)(39)41), and was significant in 5 studies (23,30,34,37,38). The overall mean prevalence of MetS in COPD patients was 32% (23-58%) versus 30% (17-54%) in controls (p = 0.001).…”

Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 80%

See 1 more Smart Citation

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Lipovec

Beijers

Borst

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

134

View full text Add to dashboard Cite

Type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD). Prevention of these co-morbidities in COPD requires knowledge on their risk factors. Metabolic syndrome (MetS) predisposes to the development of T2DM and CVD but its prevalence in COPD remains unclear. The aim of this review was to assess the prevalence of MetS and its components in COPD patients compared to controls and to investigate the contribution of clinical characteristics to MetS prevalence. We systematically searched PubMed and EMBASE for original studies in COPD that have investigated the prevalence of MetS and its components. In total, 19 studies involving 4208 COPD patients were included. The pooled MetS prevalence was 34%. Compared to controls, the prevalence was higher in COPD (10 studies, 32% and 30%, p = 0.001). The three most prevalent components in both COPD and controls were arterial hypertension (56% and 51%), abdominal obesity (39% and 38%) and hyperglycemia (44% and 47%). Compared to COPD patients without MetS, those with MetS had higher body mass index (BMI) (29.9 and 24.6 kg/m 2 , p < 0.001), higher forced expiratory volume in 1 second (FEV 1 ) % predicted (54 and 51, p < 0.001) and were more frequently female (31% and 25%, p = 0.011). In conclusion, the prevalence of MetS in COPD patients is high and hypertension, abdominal obesity and hyperglycemia are the most prevalent components. Further studies are needed to evaluate the impact of lifestyle factors and medications on MetS in COPD.

show abstract

Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 80%

“…In total, 10 studies compared COPD patients (n = 2864) with a control group (n = 24532) (25,30,34,(36)(37)(38)(39)(40)(41). Characteristics of COPD patients are shown in Table 2, characteristics of the controls are presented in Supplemental Table S1.…”

Section: Differences In Prevalence Of Mets and Its Components Betweenmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Lipovec

Beijers

Borst

et al. 2016

COPD: Journal of Chronic Obstructive Pulmonary Disease

134

View full text Add to dashboard Cite

show abstract

“…To date, the prevalence of sarcopenia has only been explored in a non-institutionalised civilian population of South Korea (32.8% of male and 12.2% of female COPD patients) [11]. Clearly, the current proportions overshadow the prevalence in South Korea, but the latter was reported in a relatively healthy population, as individuals admitted to hospital or nursing homes were not included.…”

Section: Discussionmentioning

confidence: 99%

“…Non-sarcopenic patients were generally overweight to obese and overall showed better physical functioning, typically reflecting the "obesity paradox" (stating that obesity is, on one hand, associated with better survival and some functional outcomes but, on the other hand, also associated with increased risk of cardiovascular and metabolic diseases). Referring to the high prevalence of abdominal obesity in COPD patients [12] and, moreover, in sarcopenic patients [11], it was relevant to investigate if and in what direction coexistence of abdominal obesity further affected physical functioning in COPD patients. This group of sarcopenic patients with concomitant abdominal obesity generally displayed a higher physical functioning than sarcopenic patients without abdominal obesity.…”

Section: Discussionmentioning

confidence: 99%

“…In the general well-functioning aged population, sarcopenia according to this definition is prevalent in ∼15% [10], but only sparse data are available in COPD. In a non-institutionalised civilian population of South Korea, sarcopenia was found in 32.8% of male and 12.2% of female COPD patients [11]. However, no data are yet available from a European population, or from patients eligible for pulmonary rehabilitation which are characterised by impaired physical functioning.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

et al. 2015

View full text Add to dashboard Cite

Decreased physical performance due to loss of muscle mass (i.e. sarcopenia) is prevalent in ageing and appears more pronounced in chronic disease. A comprehensive profile of the sarcopenic phenotype in chronic obstructive pulmonary disease (COPD) is not yet available. The aim of the present study was to characterise prevalence, functional implications and predictive value of sarcopenia with or without abdominal obesity in Dutch COPD patients eligible for pulmonary rehabilitation.505 COPD patients (aged 37-87 years; 57% male) underwent assessment of lung function, body composition and physical functioning, before entering pulmonary rehabilitation. Sarcopenia was assessed by appendicular skeletal muscle index (ASMI) and abdominal obesity by android/gynoid percentage fat mass (A/G%FM) using dual energy X-ray absorptiometry.86.5% of patients were sarcopenic and showed lower physical functioning, while coexistent abdominal obesity (78.0%) resulted in higher physical functioning. Implications on endurance were less pronounced in women. The predictive value for physical functioning was higher for the "three-compartment" model (ASMI, bone mineral content and A/G%FM) than the "two-compartment" model (fat-free mass index and fat mass index) or "one-compartment" model (body mass index).In patients eligible for pulmonary rehabilitation, sarcopenia is highly prevalent in all body mass index categories and associated with impaired strength, and in men also with decreased endurance. Abdominal obesity seems to have protective effects on physical functioning. ASMI is a better predictor for physical functioning than fat-free mass index. @ERSpublications Highly prevalent sarcopenia and abdominal obesity in COPD patients exert antagonistic effects on physical functioning http://ow.ly/L5b9r

show abstract

Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011

et al. 2015

View full text Add to dashboard Cite

show abstract

Association between Sarcopenia and Metabolic Syndrome in Chronic Obstructive Pulmonary Disease: The Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011

Abstract: The restrictive spirometric pattern is associated with metabolic syndrome, and sarcopenia may contribute to the risk of metabolic syndrome in male patients with COPD.

Cited by 37 publications

References 27 publications

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

The Prevalence of Metabolic Syndrome In Chronic Obstructive Pulmonary Disease: A Systematic Review

Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD

Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011

Contact Info

Product

Resources

About