Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population

Boghdady, Ahmed; Arafa, Usama Ahmed; Sabet, Eman A.; Salama, Eman H; Sharawy, Ahmed El; El-Badry, Mahmoud

doi:10.21037/cdt.2015.12.15

Cited by 15 publications

(33 citation statements)

References 23 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taking our findings together, the AA genotype of rs1761667 was associated with higher dietary intake of MUFA, which may be associated with decreased blood pressure and lower risk of CVD (44,45) . Although significant associations between the genotypes of CD36 polymorphisms (rs1761667 and rs1527483) and anthropometric and lipid indices have been observed in many studies in Caucasian (17,18) and African American populations (21,22) , we did not find any such associations among community-dwelling Japanese adults in Japan. Our result is in line with previous studies in Asians, showing no significant relationship between the two polymorphisms and those phenotypes (12,25) .…”

Section: Discussioncontrasting

confidence: 96%

“…Along with the nutritional perspective, many CD36 SNP have been reported to be associated with various diseases and metabolic abnormalities in European and African American populations (5,8,10,11,(13)(14)(15)(17)(18)(19)(20)(21)(22)(23)(24) . Based on these previous studies, recent case-control studies have investigated the associations of CD36 polymorphisms with ischaemic stroke (25,26) and CHD in Asian populations (27)(28)(29) .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

et al. 2019

View full text Add to dashboard Cite

Cluster of differentiation 36 (CD36) is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n 495). Dietary nutrient intake was estimated from a validated short FFQ and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using PCR with confronting two-pair primers method. Mean age was 63·4 (sd 9·9) years. Individuals with the AA genotype showed higher total fat and MUFA intake (standardised β = 0·110 and 0·087, P = 0·01 and 0·05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardised β = –0·123, P = 0·02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population.

show abstract

Section: Discussioncontrasting

confidence: 96%

mentioning

confidence: 99%

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The A allele of rs1761667 decreases the CD36 expression and is related with upper recognition taste thresholds for fat (i.e., lower oral sensitivity to fat) [11]. Moreover, clinical investigations have shown that polymorphisms of this gene (such as rs1761667, rs10499859, rs3173798 and rs1049673) can influence the lipid metabolism, cardiovascular risk, essential hypertension, insulin resistance, familial type 2 diabetes mellitus (T2DM) and body mass index (BMI) [12–14]. For example, this receptor has high-affinity for long chain fatty acids (FAs) and is involved in lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

Momeni-Moghaddam

Asadikaram

Abolhassani

et al. 2019

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background CD36 is associated with regulation of lipid metabolism, atherosclerosis, and blood pressure. Moreover, its variation may be involved in the development of hypertension and/or coronary artery disease (CAD). The present study was conducted to investigate the possible association of CD36 rs1761667 (G > A) polymorphism with hypertension and/or CAD in the southeastern of Iran. Methods The present observational study was composed of 238 subjects who were admitted for coronary angiography, and divided into four groups: 1) hypertensive without CAD (H-Tens, n = 52); 2) hypertensive with CAD (CAD + H-Tens, n = 57); 3) CAD without hypertension (CAD, n = 65); and 4) non-hypertensive without CAD as the control group (Ctrl, n = 64). The CD36 rs1761667 polymorphism was genotyped with PCR-RFLP method. Association between CD36 rs1761667 genotypes and the risk of CAD and hypertension was assessed using multinomial regression by adjusting for age, sex, creatinine, fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results In the present study, minor allele (A) frequency was 0.36. The genotype, but not allele frequency of the CD36 rs1761667 was significantly different between the four study groups ( p = 0.003). Furthermore, using a recessive inheritance model CD36 rs1761667 polymorphism was significantly associated with an increased risk of CAD with hypertension (OR = 5.677; 95% CI = 1.053–30.601; p = 0.043). However, using the dominant model of CD36 rs1761667 had a protective effect on H-Tens and CAD patients. Conclusion The present findings revealed an association between CD36 rs1761667 polymorphism and susceptibility to hypertension and/or CAD in a southeastern Iranian population.

show abstract

“…After screening titles and abstracts, we found 2923 records to be irrelevant and excluded them. We assessed full texts of the remaining 180 articles for eligibility, of which 22 were finally included (Abd El-Aziz et al, 2011Abdel Ghany et al, 2017;Abdel-Hamed et al, 2017;Bennouar et al, 2004;Boghdady et al, 2016;Ellman et al, 2015;Elouej et al, 2016aElouej et al, , 2016bElouej et al, , 2016cEngwa et al, 2018;Fekih et al, 2014;Hooper et al, 2007;Kefi et al, 2017;Khella et al, 2017;Kodogo et al, 2016;Masemola et al, 2007;Mehri et al, 2010;Morjane et al, 2017;Sediri et al, 2011;Sellami et al, 2018) and 158 were excluded with reasons as indicated in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…Populations, genetic assessment, and outcomes Seventeen of the 22 included studies (72.3%) were conducted in Northern Africa (7 in Egypt, 8 in Tunisia and 2 in Morocco) (Abd El-Aziz et al, 2011Abdel Ghany et al, 2017;Abdel-Hamed et al, 2017;Bennouar et al, 2004;Boghdady et al, 2016;Elouej et al, 2016aElouej et al, , 2016bElouej et al, , 2016cFekih et al, 2014;Kefi et al, 2017;Khella et al, 2017;Mehri et al, 2010;Morjane et al, 2017;Sediri et al, 2011;Sellami et al, 2018), whereas only 5 were performed in sub-Saharan African populations (1 in Zimbabweans, 1 in Nigerians, and 3 in South Africans) (Ellman et al, 2015;Engwa et al, 2018;Hooper et al, 2007;Kodogo et al, 2016;Masemola et al, 2007). Most studies were conducted among patients with coronary artery disease, diabetes mellitus, or metabolic syndrome.…”

Section: Literature Searchmentioning

confidence: 99%

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Noubiap

Mato

Guewo-Fokeng

et al. 2018

OMICS: A Journal of Integrative Biology

View full text Add to dashboard Cite

Identification of genetic/genomic factors contributing to dyslipidemia is of great interest to prevention and reduction of the onset and burden of cardiovascular diseases in Africa. This systematic review summarizes available data on genetic variants associated with dyslipidemia in populations within Africa. A PubMed and EMBASE database search was conducted to identify all studies published until June 2018 on genetic susceptibility to dyslipidemia in African-based populations, excluding familial hypercholesterolemia. All studies on genetic predispositions of dyslipidemia and respecting the preestablished inclusion criteria were included in this systematic review. Because of high heterogeneity, the data were summarized narratively. Twenty-two studies investigated mostly the targeted genetic variants. A total of 51 polymorphisms in 28 susceptibility genes to dyslipidemia have been associated with a particular trait in the African populations, and through variable effects. Most polymorphisms investigated in Northern Africa seemed to have consistent effects on increasing the level of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides in patients with diabetes, myocardial infarction, coronary artery disease, and metabolic syndrome. By contrast, only Ser447Ter and C49620T variants were associated with increased LDL-C in sub-Saharan Africa. Despite few studies available in this context in the literature, certain genetic variants were consistently associated with dyslipidemia especially in Northern Africa as highlighted in this analysis. Further data, particularly from genome-wide association studies, would help establish an African-specific reference for genetic susceptibility markers of dyslipidemia.

show abstract

Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population

Abstract: The AG genotype of the rs1761667 polymorphism in the CD36 gene may be involved in CAD pathogenesis as well as increased body mass index (BMI), T2DM and MetS in the Sohag population of Egypt.

Cited by 15 publications

References 23 publications

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Contact Info

Product

Resources

About