Association between rs11614913 polymorphism in miR-196a2 and colorectal cancer risk: A meta-analysis

Du, Wei; Ma, Xuelei; Kong, Weiqi; Liu, Tao; Wei, Benling; Yu, Jiayun; Li, Yanyan; Huang, Jingwen; Li, Zikang; Liu, Lei

doi:10.3233/cbm-140389

Cited by 7 publications

(6 citation statements)

References 64 publications

(77 reference statements)

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“… 173 Ren et al 174 reported the association of rs11614913 with lung cancer in a meta-analysis with 5 studies, which is consistent with our findings. Other meta-analyses with individual cancer susceptibility also produced conflicting outcomes, such as in breast cancer, 175 gastric cancer, 176 , 177 colorectal cancer, 178 , 179 esophageal cancer, 180 and prostate cancer. 181 …”

Section: Discussionmentioning

confidence: 99%

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Aziz

Akter

Islam

2022

Technol Cancer Res Treat

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Background: MiR-196a2 rs11614913 polymorphism has been studied in a wide range of cancers throughout the years. Despite a large number of epidemiological studies performed in almost all ethnic populations, the contribution of this polymorphism to cancer risk is still inconclusive. Therefore, this updated meta-analysis was performed to estimate a meticulous correlation between miR-196a2 rs11614913 variant and cancer susceptibility. Methods: A systematic study search was carried out using PubMed, ScienceDirect, CNKI, EMBASE, Scopus, and Google Scholar databases following PRISMA guidelines to find necessary literature up to December 15, 2021. Pooled odds ratios with corresponding 95% confidence intervals were estimated using RevMan 5.4 based on ethnicities, cancer types, control sources, and genotyping methods. Results: A total of 152 studies, including 120 135 subjects (53 818 patients and 66 317 controls; 140 studies, after removing studies that deviated from HWE: 51 459 cases and 62 588 controls), were included in this meta-analysis. Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05). It is also observed from ethnicity-based subgroup analysis that rs11614913 polymorphism is significantly ( P < .05) linked with cancer in the Asian (in CDM2, CDM3, RM, AM) and the African population (in CDM1, CDM3, ODM). Stratified analysis based on the cancer types demonstrated a significantly decreased correlation for breast, hepatocellular, lung, and gynecological cancer and an increased association for oral and renal cell cancer. Again, the control population-based subgroup analysis reported a strongly reduced correlation for HB population in CDM2, RM, and AM. A substantially decreased risk was also observed for other genotyping methods in multiple genetic models. Conclusions: MiR-196a2 rs11614913 variant is significantly correlated with overall cancer susceptibility. Besides, rs11614913 is correlated with cancer in Asians and Africans. It is also correlated with breast, gynecological, hepatocellular, lung, oral, and renal cell cancer.

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Section: Discussionmentioning

confidence: 99%

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Aziz

Akter

Islam

2022

Technol Cancer Res Treat

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“…Variation in microRNA expression has also been implicated in CRC carcinogenesis [6,9,11] with many conflicting reports regarding the association of miR-196A2 C>T polymorphism with the risk of CRC in humans [11,30,32] . Multiple genetic alterations in tumor suppressor genes like Deleted in Colorectal Cancer (DCC) gene have also been found to be associated with CRC.…”

Section: Discussionmentioning

confidence: 99%

“…Zhan et al, [47] also confirmed an enhanced expression of miR-196A2 in colorectal cancer tissues of patients with the CC or CT genotypes as compared to TT genotype. The discrepancy in results between studies regarding the probable significance of miR196A2 rs 11614913 in CRC may be attributable to some factors: Such as sample size with a consequent reduced statistical power to assess the association between the polymorphisms and susceptibility to CRC; histological patterns or types of CRC; different ethnicity and genetic variants or different molecular pathological mechanisms that contribute differently to cancer [32,41] . Therefore, further studies with larger sample size and incorporation of gene-gene and gene-environment interactions are warranted to confirm these findings [41,48] .…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Cyclin D1 and Variations of MIR 196A2 and Deleted in Colorectal Cancer (DCC) Genes with Colorectal Cancer

SELIM¹,

El-SAYED²,

FARGHALY³

et al. 2022

The Medical Journal of Cairo University

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Background: Colorectal Cancer is the 5 th common malignant tumor among Egyptians representing 5% of the total cancers according to National Cancer Registry 2013. Aim of Study:To evaluate association of serum level of Cyclin D1 and variants in MicroRNA196a-2 (miR196A2) rs11614913 and Deleted in colorectal cancer (DCC) rs714 genes with the risk of colorectal cancer and its progression.Patients and Methods: A case-control study was done on 100 colorectal cancer (CRC) patients and 60 healthy controls were enrolled and were genotyped for miR196A2 rs11614913 gene variation using the real time-Taq Man assay and DCC rs714 gene variation using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Serum levels of Cyclin D1 were measured by Enzyme linked immunosorbant assay (ELSA).Results: Pathogenic variant G of DCC was associated with an increased risk of colorectal cancer compared to A variant (p<0.001). Also, G variant (GG and GA genotypes) was associated with increased risk of distant metastasis in patients of CRC compared to DCC A variant ( p=0.014). There was a significant association between increased serum level of Cyclin D 1 and the risk of colorectal cancer ( p=0.001) with cut-off value >3.4ng/mL. Pathogenic variant C of miR196A2 was not significantly associated with increased risk of colorectal cancer ( p=0.766) but showed a significant increase in tumor progression (p=0.013). Conclusion:Pathogenic variant G of DCC and increased serum level of Cyclin D1 are predictive factors of sporadic colorectal cancer among Egyptian patients. C variant of miR196A2 can be used as prognostic rather than diagnostic markers of CRC.

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“…To date, some studies have revealed that miRNA expression profiles and some specific miRNAs were associated with the risk of CCRCC [7][8][9][10][11][12][13][14][15][16]. Considerable studies have specified that single-nucleotide polymorphisms (SNPs) in miRNA genes could alter miRNA processing and expression and contribute to cancer risk [17][18][19][20]. However, limited information was available for CCRCC.…”

Section: Introductionmentioning

confidence: 99%

miR149 rs71428439 polymorphism and risk of clear cell renal cell carcinoma: a case–control study

et al. 2014

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Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell cancer and accounts for 70 % of renal cell cancer. CCRCC remains an enigmatic tumor type, as the molecular genetic mechanisms are still unclear. MicroRNA (miR) 149 functions as a tumor suppressor and plays an important role in the carcinogenesis of renal cells. In this study, we enrolled 1,000 CCRCC patients and 1,000 cancer-free controls to evaluate the association of miR149 rs71428439 with the risk of CCRCC by a case-control study to determine the effects on CCRCC risk. miR149 rs71428439 was significantly associated with increased CCRCC risk (odds ratio (OR) for trend = 1.53, P for trend = 4.04 × 10(-11)), with ORs (95 % confidence intervals (CIs)) of 1.42 (1.17-1.72) associated with AG genotype and 2.27 (1.76-2.94) associated with GG genotype, compared with subjects with AA genotype. The expression levels of miR149 in cancer tissues were significantly lower than those in adjacent normal tissues (P = 0.005), and per G allele has significantly lower miR149 levels in both tumor tissues and adjacent normal tissues. Our data suggest that the GG genotypes of miR149 rs71428439 predispose their carriers to CCRCC, and miR149 rs71428439 may be a new biomarker for predicting the risk of CCRCC.

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Association between rs11614913 polymorphism in miR-196a2 and colorectal cancer risk: A meta-analysis

Abstract: These findings supported that miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of CRC.

Cited by 7 publications

References 64 publications

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Association of Serum Cyclin D1 and Variations of MIR 196A2 and Deleted in Colorectal Cancer (DCC) Genes with Colorectal Cancer

miR149 rs71428439 polymorphism and risk of clear cell renal cell carcinoma: a case–control study

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