Association between retinal vein occlusion and risk of heart failure: A 12-year nationwide cohort study

Rim, Tyler Hyungtaek; Oh, Jaewon; Kang, Seok Min; Kim, Soo Sung

doi:10.1016/j.ijcard.2016.04.174

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…After full-text reviews, 12 eligible studies with 23,656,214 individuals were finally selected to be included in the quantitative synthesis. [12][13][14][15][16][17][18][19][20][21][22][23] Among the included studies, 11 retrospective cohort studies were based on Asian population and only one casecontrol study was from Denmark. In addition, seven studies compared the prevalence of CKD between RVO and non-RVO subjects, two studies demonstrated the prevalence of CKD between CRVO and BRVO patients, and another three studies reported the prevalence of RVO (including CRVO and BRVO) in ESRD and non-ESRD participants (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Retinal vein occlusion and chronic kidney disease: A meta-analysis

Fang

Dong

et al. 2020

European Journal of Ophthalmology

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Objectives: We performed this meta-analysis to assess the correlation of retinal vein occlusion (RVO) and chronic kidney disease (CKD). Methods: We searched PubMed, Embase, Web of Science and Cochrane Library for population-based studies reporting the CKD as associated factor to RVO, central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO). Then we pooled the data for analysis. Results: After screening potential literature, 12 eligible studies with 23,656,214 individuals were finally included in quantitative synthesis. The pooled prevalence (95% confidence interval [CI]) of CKD in RVO group was 10.9% (95% CI: 6.6%, 15.1%). The pooled prevalence of any RVO in end stage renal disease (ESRD) group was 1.8% (95% CI: 1.6%, 2.1%). The prevalence of CKD was significantly higher in subjects diagnosed with RVO than non-RVO participants (odds ratio [OR]: 3.30; 95% CI: 2.28, 4.76; p < 0.001). CRVO subjects had a higher prevalence of CKD than BRVO patients (OR: 2.17; 95% CI: 1.28, 4.66; p = 0.004). In a similar manner, compared to non-ESRD subjects, ESRD patients had significantly higher prevalence of RVO (OR: 2.19; 95% CI: 1.97, 2.43; p < 0.001), CRVO (OR: 2.61; 95% CI: 2.17, 3.15; p < 0.001) and BRVO (OR: 2.01; 95% CI: 1.76, 2.30; p < 0.001). Conclusion: The prevalence of CKD increases in RVO patients, especially in CRVO. And in turn, the prevalence of RVO also increases in ESRD patients. The data support a correlation of RVO and CKD.

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Section: Resultsmentioning

confidence: 99%

Retinal vein occlusion and chronic kidney disease: A meta-analysis

Fang

Dong

et al. 2020

European Journal of Ophthalmology

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“…Studies on the association between CRVO and various cardiovascular conditions such as stroke, PVD, arterial thromboembolic disease and coronary artery diseases, and CHF have yielded conflicting results. 2,15,38,53 Such discrepancy may suggest underlying weak associations of these risk factors. Limited studies have evaluated these risk factors in younger population.…”

Section: Cardiovascular Risk Factors and Crvomentioning

confidence: 99%

Risk factors for central retinal vein occlusion in young adults

Chen

Uppuluri

Zarbin

et al. 2020

European Journal of Ophthalmology

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Purpose: Several risk factors have been identified for central retinal vein occlusion (CRVO) in older population. CRVO in young is uncommon, and the risk factors for this group are unclear. This large retrospective, cross-sectional study used the National Inpatient Sample (NIS) database to evaluate the risk factors for CRVO in patients 18 to 40 years of age. Methods: The 2002 to 2014 NIS database was used. All patients 18 to 40 years of age with a primary diagnosis of CRVO were identified. Age- and gender-matched non-CRVO controls were randomly selected. The primary outcome was identification of risk factors for CRVO. Chi-square analysis and Firth logistic regression were performed with IBM SPSS 23 and R packages versions 3.4.3, respectively. p < 0.05 was considered significant. Results: A total of 95 weighted young CRVO patients were identified. The average age was 31.44 ± 6.41 years with no gender predilection. Systemic and ocular conditions found to have statistically significant associations with CRVO included primary open-angle glaucoma (POAG) (OR 836.72, p < 0.001), retinal vasculitis (OR 705.82, p < 0.001), pseudotumor cerebri (OR 35.94, p < 0.001), hypercoagulable state (OR 25.25, p < 0.001), history of deep vein thrombosis/pulmonary embolism (DVT/PE) (OR 21.88, p < 0.001), and hyperlipidemia (OR 3.60, p = 0.003). Conclusion: The most significant risk factors for CRVO in young adults were POAG, retinal vasculitis, and pseudotumor cerebri. Hypercoagulable states and DVT/PE were also associated with CRVO in this population. Systemic inflammatory conditions were not associated with CRVO. Traditional risk factors such as hypertension and diabetes did not pose significant risks, whereas hyperlipidemia was deemed a significant risk factor.

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“…The Agatston score, a quantification of CAC calculated as the sum of all coronary calcified lesion scores, with total area and maximal density of calcification in cardiac-gated CT, has been the reference standard method and the most commonly utilized approach for subclinical atherosclerosis detection with well-established categorization for CVD risk prediction (CAC = 0, low risk; CAC = 1-300, intermediate risk; CAC > 300, high risk) [7]. Recently, many studies have shown that retinal vessel caliber change or retinopathy (e.g., retinal vein occlusion), depicted on digitized retinal photographs, may serve as an early indicator of coronary microvascular damage in association with risk of hypertension, left ventricular remodeling, and clinical CHD [8][9][10][11][12][13][14][15][16]. These conclusions were based on the assumption that microvascular and macrovascular atherosclerotic processes may play a prominent role in the development of clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Coronary Artery Calcification and Central Chorioretinal Thickness in Patients with Subclinical Atherosclerosis

Kim¹,

Kim

et al. 2020

Ophthalmologica

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Purpose: To evaluate the relationship between coronary artery calcification and subfoveal thicknesses of individual chorioretinal layers in subjects with subclinical atherosclerosis by using enhanced-depth imaging optical coherence tomography. Methods: In this retrospective, noninterventional, cross-sectional study, we included 193 eyes from 193 subjects and divided them into three cardiovascular (CV) risk groups based on coronary artery calcification (CAC) scores calculated from cardiac-gated computed tomography: low (CAC = 0; n = 77), intermediate (CAC = 1–300; n = 83), and high (CAC >300; n = 33). Central macula individual retinal layer thicknesses and subfoveal choroidal thickness were measured and compared among groups. Multivariate linear regression was used to evaluate associations of subfoveal choroidal thickness or central retinal thickness with CAC scores. Results: Average subfoveal choroidal thickness differed significantly among low, intermediate, and high CV risk groups (all p < 0.05). There were no statistically significant changes in segmented retinal layer thickness of the central macula. Multivariate regression analyses showed that higher CAC scores were significantly negatively associated with subfoveal choroidal thickness (β = –2.169, p < 0.001). Conclusions: Higher CAC scores were significantly associated with subfoveal choroidal thinning in subjects with subclinical atherosclerosis. Prominent reductions in the subfoveal choroidal layer could provide a useful biomarker for predicting CV risk in patients of advanced age with subclinical atherosclerosis.

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Association between retinal vein occlusion and risk of heart failure: A 12-year nationwide cohort study

Cited by 13 publications

References 26 publications

Retinal vein occlusion and chronic kidney disease: A meta-analysis

Retinal vein occlusion and chronic kidney disease: A meta-analysis

Risk factors for central retinal vein occlusion in young adults

Relationship between Coronary Artery Calcification and Central Chorioretinal Thickness in Patients with Subclinical Atherosclerosis

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