Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis

Fontana, Andrea; Spadaro, Sara; Copetti, Massimiliano; Spoto, Belinda; Salvemini, Lucia; Pizzini, Patrizia; Frittitta, Lucia; Mallamaci, Francesca; Pellegrini, Fabio; Trischitta, Vincenzo; Menzaghi, Claudia

doi:10.1371/journal.pone.0120419

Cited by 75 publications

(58 citation statements)

References 27 publications

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“…Each 10 ng/ml higher serum resistin was associated with a 17% higher risk of death even after adjusting for confounders such as socio-demographic parameters, residual kidney function, nutritional/inflammatory parameters, comorbidities, and transplantation-related covariates. Our findings are similar to what was recently described across various types of heterogeneous populations in a meta-analysis, although not all studies detected a resistin-mortality association [32,33]. There are several different pathways that may explain the association between resistin and death.…”

Section: Discussionsupporting

confidence: 91%

Association between serum resistin level and outcomes in kidney transplant recipients

Nagy

Újszászi

Czira³

et al. 2016

Transpl Int

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SummaryResistin is an adipocytokine that is associated with inflammation, coronary artery disease, and other types of cardiovascular disease among patients with normal kidney function. However, little is known about the association of resistin with outcomes in kidney transplant recipients. We collected socio-demographic and clinical parameters, medical and transplant history, and laboratory data from 988 prevalent kidney transplant recipients enrolled in the Malnutrition-Inflammation in Transplant-Hungary Study (MINIT-HU study). Serum resistin levels were measured at baseline. Associations between serum resistin level and death with a functioning graft over a 6-year follow-up period were examined in unadjusted and adjusted models. The meanAESD age of the study population was 51 AE 13 years, among whom 57% were men and 21% were diabetics. Median serum resistin concentrations were significantly higher in patients who died with a functioning graft as compared to those who did not die during the follow-up period (median ng/ml, respectively; P < 0.001). Higher serum resistin level was associated with higher mortality risk in both unadjusted and fully adjusted models: HRs (95% CI): 1.33(1.16-1.54) and 1.21 (1.01-1.46), respectively. In prevalent kidney transplant recipients, serum resistin was an independent predictor of death with a functioning graft.

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Section: Discussionsupporting

confidence: 91%

Association between serum resistin level and outcomes in kidney transplant recipients

Nagy

Újszászi

Czira³

et al. 2016

Transpl Int

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“…4–7 including 7 studies reported that circulating resistin levels were associated with mortality, especially in high-risk individuals, such as patients with diabetes. 8 Diabetic patients have been reported to have higher levels of resistin compared to non-diabetic patients, suggesting some specific role of resistin in this high-risk population. 9,10 In older adults, inflammatory markers, such as interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) have been independently associated with CVD events with an incremental improvement of prediction.…”

Section: Introductionmentioning

confidence: 96%

Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study

et al. 2016

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Objective Prospective data on the association between resistin levels and cardiovascular disease (CVD) events are sparse with conflicting results. Methods We studied 3044 aged 70–79 years from the Health, Aging, and Body Composition Study. CVD events were defined as coronary heart disease (CHD) or stroke events. «Hard» CHD events were defined as CHD death or myocardial infarction. We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum resistin concentrations and adjusted for clinical variables, and then further adjusted for metabolic disease (body mass index, fasting plasma glucose, abdominal visceral and subcutaneous adipose tissue, leptin, adiponectin, insulin) and inflammation (C-reactive protein, interleukin-6, tumor necrosis factors-α). Results During a median follow-up of 10.1 years, 559 patients had «hard» CHD events, 884 CHD events and 1106 CVD Events. Unadjusted incidence rate for CVD events was 36.6 (95% CI 32.1–41.1) per 1000 persons-year in the lowest quartile and 54.0 per 1000 persons-year in the highest quartile (95% CI: 48.2–59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20–1.93, P< 0.001) for «Hard» CHD events, 1.41 (95% CI 1.16–1.70, P=.001) for CHD events and 1.35 (95% CI 1.14–1.59, P=0.002) for CVD events. Further adjustment for metabolic disease slightly reduced the associations while adjustment for inflammation markedly reduced the associations. Conclusions In older adults, higher resistin levels are associated with CVD events independently of clinical risk factors and metabolic disease markers, but markedly attenuated by inflammation.

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“…2G and H). Human resistin is a proinflammatory cytokine expressed in and secreted by monocytic cells, and a recent metaanalysis provided evidence for an association between higher circulating resistin levels and increased mortality (28,29). Furthermore, resistin gene expression is positively correlated with insulin resistance in humans.…”

Section: Discussionmentioning

confidence: 99%

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

Brøns

Saltbæk

Friedrichsen

et al. 2016

European Journal of Endocrinology

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Objective: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of hormones, substrates and inflammatory markers implicated in T2D pathophysiology compared with matched individuals born appropriate for gestational age (AGA). Methods: We collected hourly blood samples for 24 h, to measure levels of glucose, free fatty acids (FFA), triglycerides (TG), insulin, C-peptide, leptin, resistin, ghrelin, plasminogen activator inhibitor-1 (PAI-1), incretins (GLP-1 and GIP), and inflammatory markers (TNF-α and IL-6) in 13 young men born SGA and 11 young men born AGA. Results: Repeated measurements analyses were used to analyze the diurnal variations and differences between groups. The SGA subjects had increased 24-h glucose (P = 0.03), glucagon (P = 0.03) and resistin (P = 0.003) levels with no difference in diurnal rhythms compared with AGA controls. We found significant diurnal variations in levels of blood glucose, plasma TG, FFA, insulin, C-peptide, GLP-1, GIP, leptin, visfatin, TNF-α, IL-6 and PAI-1. The variation in FFA levels differed between the groups during the evening. Plasma ghrelin and glucagon levels did not display diurnal variations. Conclusions: Young men born SGA exhibit elevated 24-h blood glucose, and plasma glucagon and resistin levels with no major differences in diurnal rhythms of these or other key metabolic hormones, substrates or inflammatory markers implicated in the origin of adiposity and T2D.

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Association between Resistin Levels and All-Cause and Cardiovascular Mortality: A New Study and a Systematic Review and Meta-Analysis

Cited by 75 publications

References 27 publications

Association between serum resistin level and outcomes in kidney transplant recipients

Association between serum resistin level and outcomes in kidney transplant recipients

Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study

Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

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