2017
DOI: 10.21873/cgp.20046
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Association Between RASSF1A Promoter Methylation and Testicular Germ Cell Tumor: A Meta-analysis and a Cohort Study

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Cited by 11 publications
(9 citation statements)
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“…The field of Epigenetics in TGCTs has been expanding in the last years, with a growing number of publications on the topic. Most studies have focused on methylation [26,27,28,29] and on microRNAs (miRs) [30,31,32,33], where the major breakthroughs in TGCTs have taken place. Protein-coding epigenetic players, including DNA-modifying enzymes, histone-modifying enzymes, and ChRCs, have been explored in diverse tumor models in the recent years; however, little attention has been paid to TGCTs.…”
Section: Protein-coding Epigenetic Players In Testicular Germ Cellmentioning
confidence: 99%
“…The field of Epigenetics in TGCTs has been expanding in the last years, with a growing number of publications on the topic. Most studies have focused on methylation [26,27,28,29] and on microRNAs (miRs) [30,31,32,33], where the major breakthroughs in TGCTs have taken place. Protein-coding epigenetic players, including DNA-modifying enzymes, histone-modifying enzymes, and ChRCs, have been explored in diverse tumor models in the recent years; however, little attention has been paid to TGCTs.…”
Section: Protein-coding Epigenetic Players In Testicular Germ Cellmentioning
confidence: 99%
“…In TGCT, downregulated tumor suppressor gene RASSF1A increases proliferation [ 110 , 215 ]. TGCT also has a downregulated RB1 [ 216 ].…”
Section: Perspectives and Conclusionmentioning
confidence: 99%
“…It has been assumed that RASSF1 inactivation may be among the first events of TGCT tumorigenesis [58]. PRSS21 is assumed to act as a tumor suppressor gene whose inactivation plays an essential role in TGCT development [6].…”
Section: Healthy Controlsmentioning
confidence: 99%