Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

Eyben, Finn Edler von; Kristiansen, Karsten; Kapp, Daniel S.; Hu, Rong; Preda, Ovidiu; Nogales, Francisco F.

doi:10.3390/ijms24044148

Cited by 4 publications

(1 citation statement)

References 208 publications

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“…The testicular germ cell tumours (TGCT) have high heritability, which can be estimated at 37–49% [ 1 ]. Its constantly increased incidence has doubled over the last 20 years [ 2 ], strongly suggesting that both genetic and environmental factors are likely to shape genetic and non-genetic TGCT inheritances [ 3 , 4 ]. Although the genetic TGCT inheritance has been recently suggested by the identification of several susceptible loci associated with TGCT [ 5 ], environmentally induced marks that may be involved in non-genetic (epigenetic) TGCT inheritance are still unknown [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study

Dupont,

Stathopoulou,

Illy

et al. 2023

Epigenetics

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Testicular germ cell tumours (TGCTs) are the most common tumours in young adults of European ancestry. The high heritability and the constantly increased incidence, which has doubled over the last 20 years, strongly suggest that both genetic and environmental factors are likely to shape the TGCT susceptibility. While genome-wide association studies have identified loci associated with TGCT susceptibility, the role played by environmental molecular vectors in TGCT susceptibility remains unclear. Evidence shows that sperm non-coding RNAs provide a good vision of the environmental stresses experienced by men. Here, to determine whether TGCT impacts the abundance of specific non-coding RNAs in sperm, small RNA deep sequencing analysis of sperm of 25 men aged between 19 and 42 years, diagnosed with ( n = 16) or without ( n = 9) TGCT was performed. The primary analysis showed no statistical significance in the sncRNA population between the TGCT and non-TGCT groups. However, when sperm physiological parameters were considered to look for differentially expressed sncRNA, we evidenced 11 differentially expressed sncRNA between patients and control which allow a clear discrimination between control and TGCT samples after Hierarchical Clustering analysis. Together, these findings indicate that sperm small non-coding RNAs abundance may have the potential for diagnosing men with TGCT. However, specific care should be taken regarding sperm physiological parameters of the TGCT patients. Hence, larger studies are needed to confirm our findings and to determine whether such a signature associates with the risks to develop TGCT.

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Section: Introductionmentioning

confidence: 99%

Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study

Dupont,

Stathopoulou,

Illy

et al. 2023

Epigenetics

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miRNAs orchestration of testicular germ cell tumors – Particular emphasis on diagnosis, progression and drug resistance

Elesawy,

Abulsoud,

Moustafa

et al. 2023

Pathology - Research and Practice

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Cryptorchidism and testicular cancer in the dog: unresolved questions and challenges in translating insights from human studies

Soto-Heras,

Reinacher,

Wang

et al. 2024

Biology of Reproduction

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Cryptorchidism, the failure of one or both testes to descend into the scrotum, and testicular cancer show a strong correlation in both dogs and humans. Yet, long-standing medical debates persist about whether the location of undescended testes directly causes testicular cancer in humans or if both conditions stem from a common origin. Although testicular cancer is a prevalent disease in dogs, even less is known about its cause and correlation with testicular descent in this species. This review investigates the relation between these two disorders in dogs, drawing insights from human studies, and examines key biomarkers identified thus far. In addition, it explores potential causal links, including the impact of temperature on maturing testicular cells and a potential shared genetic origin. Notably, this literature review reveals significant differences between men and dogs in reproductive development, histological and molecular features of testicular tumors, and the prevalence of specific tumor types, such as Sertoli cell tumors (SCTs) in cryptorchid dogs and germ cell tumors (GCTs) in humans. These disparities caution against using dogs as models for human testicular cancer research and underscore the limitations when drawing comparisons between species. The paper concludes by suggesting specific research initiatives to enhance our understanding of the complex interplay between cryptorchidism and testicular cancer in dogs.

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Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

Cited by 4 publications

References 208 publications

Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study

Impact of testicular cancer on sperm small non-coding RNA signature: a pilot study

miRNAs orchestration of testicular germ cell tumors – Particular emphasis on diagnosis, progression and drug resistance

Cryptorchidism and testicular cancer in the dog: unresolved questions and challenges in translating insights from human studies

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