Association between psoriasis and dementia: A systematic review

Zhao, Jinrong; Li, T.; Wang, J.

doi:10.1016/j.nrl.2020.12.007

Cited by 10 publications

(13 citation statements)

References 46 publications

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“…A handful of evidence indicates a pathogenic role of inflammation, including cutaneous inflammation, in the development of cognitive dysfunction. For example, the incidence of dementia and Alzheimer’s disease is higher in subjects with inflammatory skin disorders such as psoriasis and eczematous dermatitis 24,25 . The crucial role of inflammation in cognitive impairment is further supported by several clinical observations in both humans and mice.…”

Section: Discussionmentioning

confidence: 90%

“…For example, the incidence of dementia and Alzheimer's disease is higher in subjects with inflammatory skin disorders such as psoriasis and eczematous dermatitis. 24,25 The crucial role of inflammation in cognitive impairment is further supported by several clinical observations in both humans and mice. Previous studies showed that either knockout of IL-1 receptor 1 or given IL-1 receptor antagonist accelerated memory recovery in a mouse model of memory impairment induced by hypoxia/reoxygenation.…”

Section: Discussionmentioning

confidence: 94%

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A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Wang

Kim

et al. 2022

Acad Dermatol Venereol

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Background Cognitive impairment is common in the elderly. Prior studies suggest a link between chronic inflammation and cognitive dysfunction, while aging‐associated epidermal dysfunction has been connected to elevations in circulating cytokines. Objective We assessed here whether improvements in epidermal function can mitigate the progression of cognitive impairment. Methods This randomized, open‐label pilot trial was carried out in two cities in northern China. A total of 200 participants aged ≥65 years were randomly assigned to the emollient‐treated and untreated groups at 1:1 ratio. Participants in the treated group were treated topically with Atopalm cream® twice‐daily from November to the following May each year for three consecutive years, while the untreated subjects served as controls. The Global Deterioration Scale (GDS) was used to assess the severity of cognitive impairment, while epidermal biophysical properties were measured on the forearms and the shins in parallel. Results Over the three‐year trial, GDS significantly increased from baseline (P < 0.0001) in the controls, while in the treated group, GDS stabilized. While stratum corneum hydration on the forearms did not change significantly in the controls, transepidermal water loss rates (TEWL), significantly increased by the end of the trial compared to baselines in the controls (P < 0.0001). On the forearms of the treated group, stratum corneum hydration increased (P < 0.0001) while skin surface pH decreased from baseline (P < 0.0001). Conclusions These results suggest that improvements in epidermal function with topical emollient can mitigate the progression of cognitive impairment. However, the sample size was relatively small, and trials in a larger cohort are needed to validate the present results.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 94%

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Wang

Kim

et al. 2022

Acad Dermatol Venereol

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“…The first two articles concerned AD and were rather in favor of the association between these two entities. An article, by Zhao et al, reviewed the possibility that psoriasis increases the risk of dementia (Zhao et al, 2021 ). They concluded that most studies support such a hypothesis, but of course, more studies are required for definite conclusions (Zhao et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…An article, by Zhao et al, reviewed the possibility that psoriasis increases the risk of dementia (Zhao et al, 2021 ). They concluded that most studies support such a hypothesis, but of course, more studies are required for definite conclusions (Zhao et al, 2021 ). A review by Zhang et al introduced a hypothesis of a bidirectional link between psoriasis and AD: on one hand, psoriasis predisposes to AD, but on the other hand, AD patients may be at increased risk of psoriasis (Zhang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Psoriasis and neurodegenerative diseases—a review

Nowowiejska

Baran

Flisiak

2022

Front. Mol. Neurosci.

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Psoriasis is a chronic skin disease with underlying genetic, inflammatory and immunological background, which is a great medical problem, currently regarded as a systemic condition. Neurodegenerative diseases (NDs) are characterized by a progressive loss of nervous tissue, which affects elderly people more frequently; therefore, it is suspected that, due to society's aging, morbidity is going to increase. We performed a thorough review in order to investigate for the first time whether psoriasis may predispose to different particular neurodegenerative diseases—Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). PubMed search resulted in the retrieval of 833 records, of which 77 eligible were included in the review. Our thorough analysis revealed there are some potential links between psoriasis and NDs (inflammation, oxidative stress, genetics, cardiometabolic disorders), but there is no strong evidence that psoriasis may predispose to NDs. Based on the evidence, it seems that the risk of PD in psoriatics is not increased, and the evidence for increased risk of AD slightly prevails the data that state the opposite. ALS risk does not seem to be increased in psoriatics. The paucity of original studies does not allow for the formulation of definitive conclusions but encourages to perform further investigations.

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“…Most of the included studies have been conducted in Asia, the United States, or Europe and the majority were retrospective cohort studies. Between 3 and 7 studies were included in the quantitative analyses [12][13][14] and 8 studies were reported in the systematic review by Zhao et al [15]. Although some of the studies have been reported multiple times, the reviews and meta-analyses included 14 differ-ent studies in total [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Association Between Psoriasis and Dementia: A Retrospective Cohort Study

Zingel¹,

Jacob

Smıth

et al. 2023

ADR

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Background: To date, no large study has examined the relationship between psoriasis and dementia in Germany. Objective: The aim of this study was to assess the association between psoriasis and the risk of all-cause dementia in patients followed in general practices in Germany. Methods: This retrospective cohort study is based on longitudinal data from the IQVIATM Disease Analyzer database and included patients with an initial diagnosis of psoriasis between January 1995 and December 2014 in 1,173 general practices in Germany. Patients without psoriasis were matched individually (1:1) to psoriasis patients using propensity scores. The main outcome of the study was the cumulative incidence of dementia diagnoses within up to 15 years of the index date. Univariate Cox proportional regression models were used to assess the relationship between psoriasis or psoriatic arthritis and dementia. Results: The present study included 10,583 patients with a diagnosis of psoriasis and 10,583 controls without psoriasis. After 15 years of follow-up, 22.0% of the psoriasis patients and 19.1% (p < 0.001) of the non-psoriasis patients developed dementia. The incidence rate of dementia in 1,000 person-years was 15.0 in psoriasis patients and 11.9 in the non-psoriasis cohort. Psoriasis was significantly associated with a dementia risk (HR: 1.24; 95% CI: (1.14–1.35); p < 0.001). The association was stronger in patients with PsA (HR: 1.35; 95% CI: (0.98–1.86)) but this was not significant (p = 0.070). Conclusion: The present study found a positive association between psoriasis and all-cause dementia in patients in general practices in Germany.

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Association between psoriasis and dementia: A systematic review

Cited by 10 publications

References 46 publications

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

A topical emollient mitigates the progression of cognitive impairment in the elderly: a randomized, open‐label pilot trial

Psoriasis and neurodegenerative diseases—a review

Association Between Psoriasis and Dementia: A Retrospective Cohort Study

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