Association between proto-oncogene mutations and clinicopathologic characteristics and overall survival in colorectal cancer in East Azerbaijan, Iran

Dolatkhah, Roya; Somi, Mohammad Hossein; Kermani, Iraj Asvadi; Bonyadi, Morteza; Sepehri, Bita; Boostani, Kamal; Azadbakht, Saleh; Fotouhi, Nikou; Farassati, Faris; Dastgiri, Saeed

doi:10.2147/ott.s116373

Cited by 8 publications

(5 citation statements)

References 29 publications

(29 reference statements)

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“…All studies are case-control studies published between 2006 and 2016. Six studies were studied from Tehran (Central of Iran) (Bishehsari et al, 2006;Roudbari et al, 2016;Shemirani et al, 2011;Sobhani et al, 2010;Tameshkel et al, 2016;Vakil et al, 2016), one study from Shiraz (Southwest of Iran) (Omidifar et al, 2015), two studies from Kermanshah (Western of Iran) (Amirifard et al, 2016;Payandeh et al, 2016), one study from Tabriz (Northwestern of Iran) (Dolatkhah et al, 2016), and one study from South Khorasan (Eastern of Iran) (Naseri et al, 2016). All studies included 1814 CRC patients that mean age of the patients was 57.5 years.…”

Section: Resultsmentioning

confidence: 99%

“…All studies included 1814 CRC patients that mean age of the patients was 57.5 years. In more studies, the prevalence of CRC in males was more than females (Amirifard et al, 2016;Bishehsari et al, 2006;Dolatkhah et al, 2016;Naseri et al, 2016;Omidifar et al, 2015;Payandeh et al, 2016;Roudbari et al, 2016;Shemirani et al, 2011;Tameshkel et al, 2016;Vakil et al, 2016). Number of mutations in codon 12 and 13 and also mutant amino acid in codon 12 has been shown in Table 1 that Gly is normal amino acid in codon 12 and can change to other amino acids.…”

Section: Resultsmentioning

confidence: 99%

“…There are very few studies about KRAS mutations in CRC from developing countries such as Iran (Bishehsari et al, 2006). The latest data from the cancer patients' registry program showed that the age-standardized incidence rate had risen from 2.8 to 5.5 in 2009 and reached 9.2 in 2012 per 100,000 persons (Dolatkhah et al, 2016). KRAS is a proto-oncogene located on the short arm of chromosome 12, encodes the protein KRAS, a GTPase involved in cell division, differentiation and apoptosis (Dobre et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The prevalence of KRAS mutation in colorectal cancer patients in Iranian population: A systematic review and meta-analysis study

et al. 2017

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Colorectal cancer (CRC) is one of the most common cancers in the World that KRAS mutations are considered as a key step in the progression of CRC. This meta-analysis study aimed to evaluate the prevalence of KRAS mutations in CRC patients in Iran. Six online databases including PubMed, Science direct, Scopus, Web of science, Cochran Library, and Scientific Information Database (SID) were searched systematically up to January 2017. A random-effects meta-analysis was used to calculate the estimation of the prevalence of KRAS mutations in CRC patients by the event rate (ER) with 95% confidence interval (95%CI). Out of 82 articles identified from the search, eleven studies included and analyzed for meta-analysis study. The studies included 1814 CRC patients that mean age of the patients was 57.5 years. The pooled ER of the studies for estimation of the prevalence of KRAS mutation in CRC patients was 32.8% (95%CI=28.7-37.3%). The pooled ER of the studies for the prevalence of codon 12 mutation was 72.5% (95%CI=59.8-82.3%) and for codon 13 mutation was 20% (95%CI=14.6-26.7%). The results showed that the prevalence of KRAS mutation in Iran was different with more studies that therefore the geographical area and race can impact on the prevalence of KRAS mutation in CRC patients. Also, codon 12 had the most prevalence among mutant codons, followed by codon 13 that Gly to Asp and Gly to Val were the most mutations in codon 12.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The prevalence of KRAS mutation in colorectal cancer patients in Iranian population: A systematic review and meta-analysis study

et al. 2017

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“…On the other hand, the Wnt signaling pathway is closely associated with BRAF mutation. Several studies have revealed very low incidence (0% -3.7%) of BRAF mutation in Asian CRCs 21,22 . Since we did not find any BRAF mutations in the same CRC samples as our previous study, this may evidence of the absence of any APC truncated mutation pattern 21 .…”

Section: Discussionmentioning

confidence: 99%

The APC gene rs41115 polymorphism is associated with survival in Iranian colorectal cancer patients

et al. 2020

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Introduction: The onset of colorectal cancer is a complex process caused by numerous genetic pathways. APC functions as a ``"gatekeeper" and its mutations occur at the initiation stage of the colorectal tumorigenesis. The main aim of this study was to investigate common somatic mutations of exon 15 APC genes in patients with colorectal cancer in East Azerbaijan, Iran. Methods: This study was designed and performed as a cross-sectional and case-only study. Tissue biopsies were obtained during colonoscopy and confirmed colorectal carcinoma cases were evaluated. Two hotspot regions of exon 15 for APC mutations were evaluated using PCR amplification and Sanger sequence analysis. Results: The synonymous (p.Thr1475Thr) polymorphism was observed in all patients; 35 patients (61.4%) had AG genotype and 22 patients (38.6%) had AA genotype. Also, a missense mutation and two deletions were found. Pearson's correlation test showed a significant correlation between the stage of the disease (rho = 0.23, P =< 0.05), and anatomical subsite of the tumor with rs41115 polymorphism (rho = 0.31, P =< 0.05). Overall comparison of survival function in the different genotypes of the APC gene showed significant differences between groups, and CRCs with AG genotype had 3.24-fold higher hazard of mortality than CRCs with AA genotype (HR = 3.24; 95% CI: 1.21 - 8.68, P = 0.020). Conclusion: APC mutation plays an important predictive role in overall survival. However, the pattern and type of APC gene have a diverse impact on clinical outcomes in the Asian population. Moreover, in CRC patients the APC mutations were reported to be diverse variants.

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“… 4 - 6 Based on the latest article published by the International Agency for Research on Cancer (2018Globocan IARC), in 2018, Colorectal Cancer consists 10.2% of all cancer cases and 9.2% of cases of cancer mortality. 7 Over 1.8 million new colorectal cancer and 881000 deaths were estimated in 2018. The lowest incidence of Colorectal Cancer is in Africa and southern Asia and the highest rate is in male population of the Republic of Korea and in female population of Macedonia.…”

Section: Introductionmentioning

confidence: 99%

Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis

et al. 2020

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Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. Survival rates are among the most important factors in quality control and assessment of treatment protocols. This study was aimed to assess the survival rate of colorectal cancer in Eastern Mediterranean Region Countries. In the present study we comprehensively searched 6 international databases including PubMed/Medline, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar for published articles until November 2018. The Newcastle-Ottawa Quality Assessment Form for Cohort Studies was applied to evaluate the quality of included studies. The heterogeneity of papers was assessed with the Cochran Test and I-Square statistics. Meta-regression test was performed based on publication year, sample size and Human Development Index (HDI) of each study. Among the total of 1023 titles found in the systematic search, 43 studies were eligible to be included in the present meta-analysis. According to the results, the 1-year, 3-year and 5-year survival rate of patients with Colorectal Cancer was 88.07% (95% CI, 83.22-92.92), 70.67% (95% CI, 66.40-74.93) and, 57.26% (95% CI, 50.43-64.10); respectively. Furthermore, Meta-regressions did not show significant correlations between survival rate and year, sample size or Human Development Index. Survival rates, especially the 5-year survival rate in the EMRO were less than European countries and the USA. Documented and comprehensive evidence-based findings of the present meta-analysis can be used to enhance policies and outcomes of different medical areas including prophylaxis, treatment and health related objectives in colorectal cancer.

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Association between proto-oncogene mutations and clinicopathologic characteristics and overall survival in colorectal cancer in East Azerbaijan, Iran

Cited by 8 publications

References 29 publications

The prevalence of KRAS mutation in colorectal cancer patients in Iranian population: A systematic review and meta-analysis study

The prevalence of KRAS mutation in colorectal cancer patients in Iranian population: A systematic review and meta-analysis study

The APC gene rs41115 polymorphism is associated with survival in Iranian colorectal cancer patients

Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis

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