Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis

Abstract

Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide. Survival rates are among the most important factors in quality control and assessment of treatment protocols. This study was aimed to assess the survival rate of colorectal cancer in Eastern Mediterranean Region Countries. In the present study we comprehensively searched 6 international databases including PubMed/Medline, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar for published articles until November 2018. The Newcastle-Ottawa Quality Assessment Form for Cohort Studies was applied to evaluate the quality of included studies. The heterogeneity of papers was assessed with the Cochran Test and I-Square statistics. Meta-regression test was performed based on publication year, sample size and Human Development Index (HDI) of each study. Among the total of 1023 titles found in the systematic search, 43 studies were eligible to be included in the present meta-analysis. According to the results, the 1-year, 3-year and 5-year survival rate of patients with Colorectal Cancer was 88.07% (95% CI, 83.22-92.92), 70.67% (95% CI, 66.40-74.93) and, 57.26% (95% CI, 50.43-64.10); respectively. Furthermore, Meta-regressions did not show significant correlations between survival rate and year, sample size or Human Development Index. Survival rates, especially the 5-year survival rate in the EMRO were less than European countries and the USA. Documented and comprehensive evidence-based findings of the present meta-analysis can be used to enhance policies and outcomes of different medical areas including prophylaxis, treatment and health related objectives in colorectal cancer.

Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam

“…Survival rates were studied previously (Coleman et al, 2011), with the 5-year survival rate at 16% in Ghana (Agyemang-Yeboah et al, 2018), 44% in Spain, 43.8% in Martinique (France) (Joachim et al, 2019), 63.5% in Brazil (Aguiar et al, 2020), and 66.6% in the United States (Siegel et al, 2017). This variation was observed within a region, that is, the 5-year survival rate in Eastern Mediterranean countries was 57.26% (50.43%-64.10%), which varied from 29.5% in Libya to 95% in Lebanon (Nikbakht et al, 2020). We found that the 5-year OS of Vietnamese patients with CRC was approximately 60% lower than those in Asian countries (Moghimi-Dehkordi and Safaee, 2012).…”

Global survival rate of patients with beta thalassemia major: a systematic review and meta-analysis

“…This tool has three different parts including Selection (4 questions), Comparability (1 question) and Outcome (3 questions), and based on the final scores divided into three categories: good, fair, and poor. [16][17][18][19] The global survival rate of patients with beta-thalassemia major: A systematic review and meta-analysis…”

New Insights Into the Anticancer Effects of p-Coumaric Acid: Focus on Colorectal Cancer

“…The incidence rates of CRC are the lowest in Africa and South Asia; nevertheless, the survival rate in African countries was reported to be less than 8%. 4 , 9 …”

“…The incidence rates of CRC are the lowest in Africa and South Asia; nevertheless, the survival rate in African countries was reported to be less than 8%. 4,9 Several factors, including genetic and inflammatory bowel disease (IBD), play a significant role in the pathogenesis of CRC. Moreover, environmental factors and nutrition are closely related to the incidence and the progression of CRC.…”