Association Between Prognosis and Tumor Laterality in Early-Stage Colon Cancer

Karim, Safiya; Brennan, Kelly; Nanji, Sulaiman; Berry, Scott; Booth, Christopher M.

doi:10.1001/jamaoncol.2017.1016

Cited by 75 publications

(60 citation statements)

References 32 publications

(49 reference statements)

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“…Half of the patients with rectal cancer had received preoperative radiotherapy, which could have resulted in eradication of lymph node metastases, and, therefore, affecting these results. A poorer prognosis for right-sided than left-sided colon cancer has been shown in stage IV CRC [25], but in stage I-III disease conflicting results are reported [26][27][28]. Right-sided colon cancer has been associated with poor differentiation grade and T4 stage, but is less likely to be node-positive, than left-sided colon cancer [27].…”

Section: Discussionmentioning

confidence: 99%

“…A poorer prognosis for right-sided than left-sided colon cancer has been shown in stage IV CRC [25], but in stage I-III disease conflicting results are reported [26][27][28]. Right-sided colon cancer has been associated with poor differentiation grade and T4 stage, but is less likely to be node-positive, than left-sided colon cancer [27]. In this study, only in stage III colon cancer tumor laterality affected OS, but this may be due to the abovementioned discrepancies.…”

Section: Discussionmentioning

confidence: 99%

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Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

et al. 2017

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Background: Most survival data in colorectal cancer (CRC) is derived from clinical trials or registerbased studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

et al. 2017

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“…The outcomes of patients with left-sided cancers are better than those of right-sided cancers in metastatic CRC [5][6][7][8]. However, the available information and findings remain limited and contradictory in localized CRC [9,10]. Thus, we aimed to evaluate the clinical characteristics and prognosis of PTL in CRC.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and prognosis of different primary tumor location in colorectal cancer: a population-based cohort study

et al. 2019

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Purpose Emerging data have shown that patients with left-sided cancers have better survival than patients with right-sided cancers in terms of metastatic colorectal cancer. However, the available information and findings remain limited and contradictory in localized colorectal cancer. This study aimed to evaluate the clinical characteristics and prognosis of primary tumor location (PTL) in colorectal cancer. Methods Patients' diagnoses were identified using the Surveillance, Epidemiology, and End Result database between 2006 and 2015. The analyses were further stipulated to patients with primary cancer site, histology, and stage information. The correlations between PTL and overall survival (OS) were assessed. Results Compared with left-sided tumors, right-sided tumors were more likely to develop into T3 cancers (50.0% vs. 44.8%), T4 cancers (15.8% vs. 12.3%), mucinous or mucin-producing adenocarcinoma (10.8% vs. 5.0%), and signet ring cell carcinoma (1.4% vs. 0.7%), P < 0.01, respectively. Patients with right-sided tumors showed inferior OS (56.1% vs. 60.2%), and the hazard ratio was 1.224 (95% CI, 1.208-1.241, P < 0.001) in all stages. Stage-specific Cox regression analysis revealed that patients with right-sided tumors also showed inferior OS in every stage (respectively, P < 0.05) than left-sided tumors. Conclusions This study demonstrated that the prognoses of patients with left-sided cancers were better than those of patients with right-sided cancers regardless of stage. PTL can be a prognosis factor in colorectal cancer. We encourage developing clinical and translational studies to elucidate the causative relationship between PTL and prognosis.

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“… 3 – 6 However, other researchers have shown that there is no significant survival difference according to tumor location. 7 , 8 Recently, an analysis of the results of six randomized trials (including CRYSTAL, FIRE-3, CALGB 80405, etc) showed that metastatic RCCs and LCCs seem to have different survival outcomes with different targeted agents. 9 Hopefully, these cancers will be treated with different approaches in the future.…”

Section: Introductionmentioning

confidence: 99%

Disparities in survival for right-sided vs. left-sided colon cancers in young patients: a study based on the Surveillance, Epidemiology, and End Results database (1990–2014)

Wang¹,

Yang²,

Zhou³

et al. 2018

CMAR

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PurposeTo investigate whether young patients exhibit different characteristics and survival according to tumor location and stage using data from the Surveillance, Epidemiology, and End Results (SEER) database.Patients and methodsYoung patients (20–49 years old) with stage I–III colon cancers were identified from the SEER program from 1990 to 2014. Kaplan–Meier survival analysis and Cox proportional hazards regression were used to analyze the data. Subset analyses were also done among different age and stage subgroups.ResultsOf 8197 patients, 3709 (45.2%) had right-sided colon cancers (RCCs). Patients with RCCs were more likely to be male, to be younger, and to have more poorly differentiated and more advanced tumors. The Kaplan–Meier survival curves and univariate survival models revealed that left-sided colon cancers (LCCs) had lower mortality for all stages combined and stage III, but higher mortality for stage II, compared with right-sided tumors. However, multivariate Cox regression models showed no significant survival differences by location for all patients (adjusted hazard ratio [HR], 0.95; 95% confidence interval [CI], 0.86–1.05; P=0.34) or for stage I (adjusted HR, 1.47; 95% CI, 0.82–2.63; P=0.20). Stage II left-sided cancers had higher mortality (adjusted HR, 1.24; 95% CI, 1.00–1.54; P=0.048), whereas stage III left-sided cancers had lower mortality (adjusted HR, 0.86; 95% CI, 0.77–0.97; P=0.01). For 20- to 39-year-old patients, a significant difference was only found in stage II disease, with a higher mortality for left-sided tumors (adjusted HR, 1.82; 95% CI, 1.12–2.97; P=0.02). However, for 40- to 49-year-old patients, a significant difference was only found in stage III disease, with a lower mortality for left-sided tumors (adjusted HR, 0.83; 95% CI, 0.72–0.95; P=0.008).ConclusionIn patients younger than 50 years, there were no significant differences in mortality between RCCs and LCCs for all stages combined after adjusting for multiple clinicopathological features. However, RCCs had lower mortality in stage II (especially in 20- to 39-year-old patients) and higher mortality in stage III (especially in 40- to 49-year-old patients).

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Association Between Prognosis and Tumor Laterality in Early-Stage Colon Cancer

Abstract: In this population-based cohort of early-stage resected colon cancer, disease laterality was not associated with long-term OS or CSS.

Cited by 75 publications

References 32 publications

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Clinical characteristics and prognosis of different primary tumor location in colorectal cancer: a population-based cohort study

Disparities in survival for right-sided vs. left-sided colon cancers in young patients: a study based on the Surveillance, Epidemiology, and End Results database (1990–2014)

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Association Between Prognosis and Tumor Laterality in Early-Stage Colon Cancer

Abstract: In this population-based cohort of early-stage resected colon cancer, disease laterality was not associated with long-term OS or CSS.

Cited by 75 publications

References 32 publications

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Clinical characteristics and prognosis of different primary tumor location in colorectal cancer: a population-based cohort study

Disparities in survival for right-sided vs. left-sided colon cancers in young patients: a study based on the Surveillance, Epidemiology, and End Results database (1990&ndash;2014)

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Disparities in survival for right-sided vs. left-sided colon cancers in young patients: a study based on the Surveillance, Epidemiology, and End Results database (1990–2014)