Association between prenatal air pollution exposure and risk of hypospadias in offspring: a systematic review and meta-analysis of observational studies

Xing, Ze; Zhang, Shuang; Jiang, Yuting; Wang, Xiuxia; Cui, Hong

doi:10.18632/aging.202698

Cited by 8 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It may be mainly related to lower access to healthcare and diagnostic technologies for birth defects in rural areas 24 . In addition, some adverse conditions in urban areas may also contribute to this phenomenon, such as air pollution [25][26][27][28] . CL and CLP were more common in males, while CP was more common in females.…”

Section: Discussionmentioning

confidence: 99%

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016–2020

Zhou,

Jiang,

Fang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study aimed to analyze the epidemiological characteristics of cleft lip and/or palate (CL/P) and CL/P-related perinatal deaths, provide some information for intervention programs to reduce the incidence of CL/P and provide clues for future researchers. Data were obtained from the Birth Defects Surveillance System in Hunan Province, China, 2016–2020. Incidences of CL/P [number of cases per 1000 fetuses (births and deaths at 28 weeks of gestation and beyond)] with 95% confidence intervals (CI) were calculated by residence, gender, maternal age, year, and major types [cleft lip only (CL), cleft palate only (CP), and cleft lip with palate (CLP)]. Crude odds ratios (ORs) were calculated to examine the association of each maternal characteristic with CL/P. Pearson chi-square tests (χ2) were used to examine the association of each maternal characteristic with CL/P-related perinatal deaths. A total of 847,755 fetuses were registered, and 14,459 birth defects were identified, including 685 CL/P (accounted for 4.74% of all birth defects). CL, CP, and CLP accounted for 24.67% (169 cases), 36.79% (252 cases), and 38.54% (264 cases) of all CL/P, respectively. The incidence of CL/P was 0.81‰ (95%CI 0.75–0.87). The incidence of CL was 0.20‰ (95%CI 0.17–0.23) (169 cases), of CP was 0.30‰ (95%CI 0.26–0.33) (252 cases), and of CLP was 0.31‰ (95%CI 0.27–0.35) (264 cases). CL was more common in males than females (0.24‰ vs. 0.15‰, OR = 1.62, 95%CI 1.18–2.22). CP was more common in urban than rural (0.36‰ vs. 0.25‰, OR = 1.43, 95%CI 1.12–1.83), and less common in males than females (0.22‰ vs. 0.38‰, OR = 0.59, 95%CI 0.46–0.75). CLP was more common in males than females (0.35‰ vs. 0.26‰, OR = 1.36, 95%CI 1.06–1.74). Compared to mothers 25–29 years old, mothers < 20 years old were risk factors for CLP (OR = 3.62, 95%CI 2.07–6.33) and CL/P (OR = 1.80, 95%CI 1.13–2.86), and mothers ≥ 35 years old was a risk factor for CLP (OR = 1.43, 95%CI 1.01–2.02). CL/P-related perinatal deaths accounted for 24.96% (171/685) of all CL/P, of which 90.64% (155/171) were terminations of pregnancy. Rural residents, low income, low maternal age, and early prenatal diagnosis are risk factors for perinatal death. In conclusion, we found that CP was more common in urban areas and females, CL and CLP were more common in males, and CL/P was more common in mothers < 20 or ≥ 35 years old. In addition, most CL/P-related perinatal deaths were terminations of pregnancy. CL/P-related perinatal deaths were more common in rural areas, and the proportion of CL/P-related perinatal deaths decreased with the increase in maternal age, parity, and per-capita annual income. Several mechanisms have been proposed to explain these phenomena. Our study is the first systematic research on CL/P and CL/P-related perinatal deaths based on birth defects surveillance. It is significant for intervention programs to prevent CL/P and CL/P-related perinatal deaths. As well, more epidemiological characteristics of CL/P (such as the location of CL/P) and approaches to reduce CL/P-related perinatal deaths need to be studied in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016–2020

Zhou,

Jiang,

Fang

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It may be related to several factors. First, some adverse conditions in urban areas may also contribute to this phenomenon, such as air pollution (19)(20)(21)(22). Second, lower access to healthcare and diagnostic technologies for birth defects in rural areas may contribute to this phenomenon (23).…”

Section: Discussionmentioning

confidence: 99%

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016-2020

Zhou

Fang

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background This study aimed to analyze the incidence of cleft lip and/or palate (CL/P) and the epidemiology of perinatal death related to CL/P. Methods We used data from the Birth Defects Surveillance System of Hunan Province, China, from 2016 to 2020. The surveillance data of perinatal infants (for stillbirth, dead fetus, or live birth between 28 weeks of gestation and seven days after birth) were analyzed. We computed the incidences of CL/P and 95% confidence intervals (CI) by Poisson regression. Furthermore, we analyzed the epidemiology of perinatal deaths related to CL/P. Results A total of 847755 perinatal infants were registered between 2016–2020. 14459 birth defects were identified, including 685 (4.74%) CL/P. The incidence of CL/P was 0.81‰ (0.75–0.87‰) (per 1000 perinatal infants). And the incidences of the cleft lip only (CL) was 0.20‰ (0.17–0.23‰) (169 cases), of cleft palate only (CP) was 0.30‰ (0.26–0.33‰) (252 cases), and of cleft lip with palate (CLP) was 0.31‰ (0.27–0.35‰) (264 cases). The incidence of CL was higher in males than females (OR = 1.62, 95%CI: 1.18–2.22). The incidence of CP was higher in urban than rural (OR = 1.43, 95%CI: 1.12–1.83) and lower in males than females (OR = 0.59, 95%CI: 0.46–0.75). The incidence of CLP was higher in urban than in rural (OR = 1.36, 95%CI: 1.06–1.74). Compared to maternal aged 25–29 years, maternal aged < 20 years was a risk factor for CLP (OR = 3.62, 95%CI: 2.07–6.33) and CL/P (OR = 1.80, 95%CI: 1.13–2.86), and maternal aged ≥ 35 years was risk factor for CLP (OR = 1.43, 95%CI: 1.01–2.02). CL/P related perinatal deaths accounted for 24.96% (171/685) of all CL/P, of which 90.64% (155/171) were aborted. Rural residents, low income, low maternal age, and early prenatal diagnosis are risk factors for perinatal death. Conclusion This study contributes to a better understanding of the incidence and risk factors of CL/P in Hunan Province, China, which is important for public health decision-making and further research.

show abstract

“…The most incriminated chemicals in this process are bisphenol, inorganic solvents, alkyl phenolic compounds, phthalates, benzophenones, parabens, siloxanes, pesticides or herbicides, diethylstilbestrol, cadmium, DDT, vinclozolin (fungicide), petroleum solvents and SO 2 (194)(195)(196)(197)(198)(199)(200)(201). Some studies are more general and incriminate the air pollution, heat, or the proximity of a vineyard in the development of hypospadias (202)(203)(204).…”

Section: Environmental Factorsmentioning

confidence: 99%

Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review)

Gozar¹,

Bara²,

Dicu³

et al. 2023

Exp Ther Med

View full text Add to dashboard Cite

Hundreds of papers are written about hypospadias every year referring to all aspects of the pathology, being one of the most common congenital malformations. The present study conducted a scoping review of articles published in 2021 to present the main issues and summarize current perspectives and achievements in the field. It searched for the keyword 'hypospadias' in the three most popular databases (PubMed, Scopus and Web of Science). After the analysis of the publications, they were categorized into different domains.

show abstract

Association between prenatal air pollution exposure and risk of hypospadias in offspring: a systematic review and meta-analysis of observational studies

Cited by 8 publications

References 48 publications

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016–2020

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016–2020

Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016-2020

Current perspectives in hypospadias research: A scoping review of articles published in 2021 (Review)

Contact Info

Product

Resources

About