Association between potentially inappropriate medications and anxiety in Japanese older patients

Masumoto, Shoichi; Maeno, Takami; Ichinohe, Yumiko; Maeno, Tetsuhiro

doi:10.1111/ggi.13128

Cited by 19 publications

(19 citation statements)

References 29 publications

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“…In those studies, the most frequent PIMs were represented by PPIs, drugs without an indication, NSAIDs, and benzodiazepines, whereas PPOs were represented by statins, antiplatelet agents, calcium, and vitamin D. [24][25][26][27] The most prevalent PIMs observed in our study are in accordance with those from other studies. [28][29][30][31][32] A study in Romania by Primejdie et al in 2016 using the STOPP/ START criteria of 2008 showed that the drug class with the highest percentage of use was NSAIDs (56.66% of outpatients and 35.63% of hospitalized patients), followed by benzodiazepines. That study did not assess PPOs.…”

Section: Discussionmentioning

confidence: 99%

<p>Potentially Inappropriate Prescriptions in Ambulatory Elderly Patients Living in Rural Areas of Romania Using STOPP/START (Version 2) Criteria</p>

Buda¹,

Prelipcean²,

Andor³

et al. 2020

CIA

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These authors contributed equally to this work Background: Rational use of medications and monitoring of prescriptions in elderly patients is important to decrease the number and duration of hospitalizations, emergency medical consultations, mortality, as well as medical costs. Purpose: To identify potentially inappropriate medications (PIMs) and potential prescription omissions (PPOs), and determine their prevalence based on the Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) v2 criteria and Screening Tool to Alert doctors to Right Treatment (START) v2 criteria for patients aged >65 years. Methods: This cross-sectional study was conducted in two rural counties in Romania based on electronic prescriptions for chronic conditions (EPCCs) issued from 30 days to 90 days by a specialist or general practitioner. Collected EPCCs were evaluated by an interdisciplinary team of specialists based on 26 STOPP v2 criteria and 10 START v2 criteria. Results: PIM prevalence was 25.80% and PPO prevalence was 41.72% for 646 EPCCs. The mean age of patients was 75 years and the mean number of drugs per EPCC was four. The most frequently identified PIMs were treatment duration (6.65%), theophylline administration (5.72%), drug indication (4.64%), cyclo-oxygenase-2 non-steroidal anti-inflammatory drugs (1.39%), and zopiclone prescription (0.77%). Statins (24.76%), beta-blockers (8.04%), and beta-2 agonist/antimuscarinic bronchodilators (5.88%) were the most frequently identified PPOs.Conclusion: PPOs were more prevalent than PIMs for elderly populations living in the two rural counties in Romania we studied. Health practitioners (family physicians, specialists, and pharmacists) should focus on prophylactic and curative considerations when prescribing agents to decrease the morbidity and mortality of elderly rural Romanian patients.

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Section: Discussionmentioning

confidence: 99%

<p>Potentially Inappropriate Prescriptions in Ambulatory Elderly Patients Living in Rural Areas of Romania Using STOPP/START (Version 2) Criteria</p>

Buda¹,

Prelipcean²,

Andor³

et al. 2020

CIA

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“…Based on the literature review of known predictors of inappropriate prescribing in older adults with and without dementia, explanatory variables that were tested for their influence on prescribing patterns were as follows: Sociodemographics: Age, gender, ethnicities, marital status, living arrangements, alcohol intake, and smoking history Clinical: Activities of daily living, self‐reported health, hospitalization, and number of medications …”

Section: Methodsmentioning

confidence: 99%

“…Clinical: Activities of daily living, 25,31 self-reported health, 25 hospitalization, 27,31 and number of medications. 32,33…”

Section: Covariatesmentioning

confidence: 99%

Determinants of prescribing potentially inappropriate medications in a nationwide cohort of community dwellers with dementia receiving a comprehensive geriatric assessment

Bala

Jamieson

Nishtala

2018

Int J Geriat Psychiatry

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Objective To identify the prevalence and predictors of prescribing potentially inappropriate medications (PIMs) in a nationwide cohort of community dwellers with dementia requiring complex care needs. Methods A cross‐matched data of the International Resident Assessment Instrument‐Home Care (9.1) (interRAI‐HC) and prescribing data obtained from the Pharmaceutical Claims Data Mart (Pharms) extract files for older adults (≥65 y) requiring complex care needs were utilized for this study. The 2015 Beers criteria were applied to identify the prevalence of PIMs in older adults with dementia. Sociodemographic and clinical predictors of PIMs were analysed using a logistic regression model. Results The study population consisted of 16 568 individuals who had their first interRAI assessment from 1 January 2015 to 31 December 2015. The estimated prevalence of dementia was 13.2% (2190/16 568). 66.9% (1465/2190) of the older adults diagnosed with dementia were prescribed PIMs, of which anticholinergic medications constituted 59.6% (873/1465). Males and individuals who were prescribed a greater number of medications were more likely to be prescribed PIMs. Individuals over 85 years of age, Māori ethnic group of individuals, older adults who were being supervised with respect to their activities of daily living, and individuals who reported good or excellent self‐reported health had a lesser likelihood of being prescribed PIMs. Conclusion We found that PIMs are prescribed frequently in older adults with dementia. Comprehensive geriatric assessments can serve as a potential tool to decrease the occurrence of PIMs in vulnerable groups with poor functional and cognitive status.

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“…This was a prospective observational cohort study, carried out as a follow up to previous work examining the association between anxiety and PIMs. 21 The present study was carried out in an outpatient clinic in the family medicine department of an urban general hospital, which provides primary healthcare in Tokyo. A total of 23 doctors with various subspecialties including parttime physicians were working in the clinic when we started the study.…”

Section: Study Design and Participantsmentioning

confidence: 99%

Potentially inappropriate medications with polypharmacy increase the risk of falls in older Japanese patients: 1‐year prospective cohort study

Masumoto

Maeno

Ichinohe³

et al. 2018

Geriatrics Gerontology Int

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Association between potentially inappropriate medications and anxiety in Japanese older patients

Cited by 19 publications

References 29 publications

<p>Potentially Inappropriate Prescriptions in Ambulatory Elderly Patients Living in Rural Areas of Romania Using STOPP/START (Version 2) Criteria</p>

<p>Potentially Inappropriate Prescriptions in Ambulatory Elderly Patients Living in Rural Areas of Romania Using STOPP/START (Version 2) Criteria</p>

Determinants of prescribing potentially inappropriate medications in a nationwide cohort of community dwellers with dementia receiving a comprehensive geriatric assessment

Potentially inappropriate medications with polypharmacy increase the risk of falls in older Japanese patients: 1‐year prospective cohort study

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