Association Between Plasma Selenium and Glutathione Peroxidase Levels And Severity of Diabetic Nephropathy in Patients With Type Two Diabetes Mellitus

Sedighi, Omid; Makhlough, Atieh; Shokrzadeh, Mohammad; Hoorshad, Shiva

doi:10.5812/numonthly.21355

Cited by 40 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, multiple studies have also suggested that oxidative stress is an important pathogenic factor of diabetes (8), hypertension (10) and other cardiovascular diseases (10). Fourth, there is also evidence indicating positive 9 correlation between the levels of oxidative stress and the severity of such diseases as diabetes (22,27). Therefore, it is reasonable to propose that the persons with more risk factors to develop AIS or MI may have higher levels of oxidative stress in their body and/or longer durations of increased oxidative stress in their body.…”

Section: Discussionmentioning

confidence: 99%

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Zhang

Tao

et al. 2018

Preprint

View full text Add to dashboard Cite

Stroke and myocardial infarction (MI) are two leading causes of death around the world. It is of great significance to establish novel and non-invasive approaches for evaluating pathological state of blood vessels, so that early interventions may be carried out to prevent incidence of stroke or MI. Our recent studies have suggested that altered 'Pattern of Autofluorescence (AF)' of skin and fingernails are novel biomarkers of acute ischemic stroke (AIS) and MI. In particular, our studies have shown characteristic increases in the green AF intensity of the fingernails and certain regions of the skin of AIS patients and MI patients. By determining the skin's green AF of the Healthy Group, the Low-Risk Group for Developing AIS, and the High-Risk Group for Developing AIS, our current study has indicated that the green AF intensity in the right and left Ventroforefingers and Dorsal Antebrachium, the right Dorsal Centremetacarpus, Dorsal Index Fingers and Centremetacarpus, as well as the left Index Fingernails and Ventriantebrachium, is highly correlated with the risk of developing AIS. Our study has also suggested that oxidative stress and inflammation may account for the increased AF intensity in the Low-Risk Group and the High-Risk Group.These findings have suggested that the green AF intensity of the fingernails and certain regions of the skin is a novel biomarker for non-invasive evaluation of the injury levels of blood vessels and the risk of developing AIS or MI.

show abstract

Section: Discussionmentioning

confidence: 99%

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Zhang

Tao

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Oxidative stress associated with preeclampsia may be a consequence of reduced antioxidant defence pathways specifically involving glutathione peroxidases, perhaps linked to reducing selenium availability [40]. Reactive oxygen species (ROS) are generated as byproducts of cellular metabolism, primarily in the mitochondria or in pathological cases which induce high oxidative stress such as in preeclampsia [41]. When the cellular production of ROS exceeds the cell's antioxidant capacity, cellular macromolecules such as lipids, proteins and DNA can be damaged, because of this, oxidative stress is thought to contribute to ageing and pathogenesis of a variety of human diseases [41].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Antioxidant Status and Lipid Peroxidation in Pre-Eclampsia

Manafa

Onyenekwe

Igwe

et al. 2019

JAMPS

View full text Add to dashboard Cite

Aim:To assess the role of antioxidants and lipid peroxidation in the pathogenesis of pre-eclampsia. Study Design: This is a case-control study designed to evaluate the levels of malondialdehyde and total antioxidant capacity with glutathione peroxidase and superoxide dismutase activities in preeclamptic. One hundred (100) participants were randomly selected to include fifty pre-eclamptic Manafa et al.; JAMPS, 21(4): 1-9, 2019; Article no.JAMPS.50664 2 (test), twenty-five (25) healthy pregnant normotensive women (control A) and twenty-five healthy non-pregnant normotensive women (control B). Original Research Article Place and Duration of Study:This study was carried out at the Holy Rosary Hospital waterside, Onitsha, Anambra state. Nigeria. The study lasted for 13 months. Methodology: One hundred women (50 pre-eclamptic, 25 pregnant normotensives and 25 nonpregnant normotensives) aged 25-40 years were recruited for this study. Blood samples were collected from the participants for the estimation of total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities using spectrophotometric methods. Blood pressures were measured using accosson sphygmomanometer. Data were analysed using analysis of variance and Pearson's correlation coefficient at p < 0.05. Results: The TAC was significantly higher in the pregnant normotensives (p< 0.05) compared with the pre-eclamptic and non-pregnant normotensives. There was no significant difference in the MDA in pre-eclamptic compared with pregnant normotensives and non-pregnant normotensives (p>0.05). A significant difference was observed in the SOD and GPx activities in the pregnant normotensive and non-pregnant normotensives compared with pre-eclamptic. A positive correlation was observed between the blood pressures (systolic and diastolic) and the activities of TAC, SOD and GPx in preeclamptic. Furthermore, a positive correlation was observed between MDA levels and SBP (r = 0.019) while a negative correlation (r = -0.225) existed between MDA and DBP. Conclusion: Diminished ability of antioxidants to scavenge free radicals may affect the onset of pre-eclampsia and therefore possible prognostic tool in its management.

show abstract

“…This may be due to the non-administration of the extract to the rats in the group. Alloxan increases blood glucose level by attacking the pancreas, thus depleting the beta cells responsible for glucose metabolism (Sedighi et al, 2014). The effectiveness of the extract to reduce the blood glucose level of the experimental animals could be attributed to the extracts ability to stimulate the pancreatic beta cells to release insulin due to the presence of the phytochemical constituent of the seed (Shlafer and Marieb, 1989).…”

Section: Administration Of Extract and Treatment Of The Animalsmentioning

confidence: 99%

Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats

2020

JPRR

View full text Add to dashboard Cite

Research Article JPRR (2020) 4:19 Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats This study evaluated the potentials of the seed extract of Ricinodendron heudelotii on the oxidative stress biomarkers of diabetic albino rats of the wistar strain. Diabetes mellitus was induced via intraperitoneal administration of 160 mg/ kg bodyweight Alloxan monohydrate in normal saline and confirmed after 120 hours of blood glucose level above 300mg/dl. Blood samples were collected from the animals and analyzed for Malondialdehyde, Catalase, Reduced Glutathione, Glutathione-S-transferase, Glutathione peroxidase, and Superoxide dismutase activities as biomarkers of oxidative stress. The result revealed a significant decrease at P≤0.05 in blood glucose concentration of diabetic rats with increase in the seed extract concentration, Malondialdehyde (MDA) decreased significantly in the diabetic rats while Catalase increased significantly at P≤0.05 as the extract concentration increased. Variations in Glutathione-S-transferase, Glutathione Peroxidase, Superoxide dismutase and Reduced Glutathione in comparison with control was observed. The results therefore suggests that the aqueous seed extract of Ricinodendron heudelotii has the potency to reduce glucose level and act as antioxidants against oxidative stress, hence its use therapeutically.

show abstract

Association Between Plasma Selenium and Glutathione Peroxidase Levels And Severity of Diabetic Nephropathy in Patients With Type Two Diabetes Mellitus

Cited by 40 publications

References 25 publications

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Assessment of Antioxidant Status and Lipid Peroxidation in Pre-Eclampsia

Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats

Contact Info

Product

Resources

About