Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats

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doi:10.28933/jprr-2019-11-1905

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The use of natural products in the enhancement, management and treatment of disease has been a global trend, with lots of recommendations and advocacy from the World Health Organization 1 . An aphrodisiac is seen as any substance that enhances sex drive or desire.…”

Section: Introductionmentioning

confidence: 99%

Male Reproductive Hormonal Activity of Synergistic Ingestion of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera in Male Rat Model

Daka,

Odinga,

Lemii

et al. 2024

Asian Sci. Bul

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Background and Objective: Masculinity encompasses sexual potency as one of its determinants. The global rise in rates of sexual dysfunctionality in males has gained much interest in the world of science, hence, a need for ways to enhance and manage sexual dysfunctionality. This study evaluated the effects of the synergistic mixture of Cyperus esculentus (tiger nuts), Phoenix dactylifera (dates) and Cocos nucifera (coconut), (STCD) on the reproductive hormones in a male rat model. Materials and Methods: Acute toxicity LD 50 of STCD was carried out according to Organization for Economic Co-operation and Development (OECD) guidelines, afterwards, fifteen male albino rats were grouped into three groups with 5 rats in each group; Control, 200 and 400 mg/kg STCD. The rats were administered STCD orally for 24 hrs, for 21 days, with feed and water ad libitum. Blood samples were collected via cardiac puncture for biochemical analysis while the tests were harvested for histological examination. The IBM SPSS, Version 25 was used for statistical analysis. Results: Acute toxicity LD 50 of STCD was observed to be $2404.2 mg/kg body weight. An increase in the serum concentration of Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH) and testosterone were observed, while a decrease in prolactin was observed in the group administered STCD at 200 and 400 mg/kg STCD with values, 0.526±0.193, 1.166±0.440, 0.756±0.130, 0.536±0.217 and 1.018±0.741, 1.700±0.835, 0.874±0.516 and 0.284±0.627, respectively, when compared to the control. The histological examination showed numerous germ cells with normal spermatozoa for control and 200 mg/kg extract, while that of 400 mg/kg extract showed a spermatic cord containing mature spermatozoa. Conclusion: The results of this present study show that STCD had enhancing effects on the male reproductive hormones investigated, thus this study suggests the enhancing potency on male sexual libido and performance of STCD. This is also evidenced by the copulatory behavior observed in the experimental rats when administered STCD.

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Section: Introductionmentioning

confidence: 99%

Male Reproductive Hormonal Activity of Synergistic Ingestion of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera in Male Rat Model

Daka,

Odinga,

Lemii

et al. 2024

Asian Sci. Bul

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Evaluation of Tumor necrosis factor (TNF-α) Concertation and Renal function in the Sera of patients with Type 2 diabetes in Erbil city

Abdulrazaaq

2024

medicra

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The research included a total of 70 samples, including 40 samples from patients diagnosed with type 2 diabetes and 30 samples from the control group. The participants' age ranged from 40 to 60 years. The samples were gathered during a one-year duration from the Chronic Diseases Unit / Diabetes Department in the city of Erbil. Later, blood samples were collected from both ill and healthy individuals, and then separated via the process of centrifugation. The variables that were evaluated include glucose, ferritin, Tumor necrosis factor-alpha (TNFα), CRP, urea, creatinine, and uric acid. The results of this research showed a significant rise in the concentrations of glucose, ferritin, TNF-alpha, CRP, urea, creatinine, and uric acid in persons with type II diabetes as compared to the control group.

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Pharmacology and Enzyme Inhibitory Potentials of Myrtus communis L. Fruits Grown in Oman

Alsenaidi,

Amush,

Ullah

et al. 2023

Trends Med. Res

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Background and Objective: Myrtus communis L. is a plant used in traditional medicine worldwide. Since many ages ago, this herb's berries have all been widely utilized as a traditional medicine to treat conditions like peptic ulcers, diarrhea, haemorrhoids, inflammation and skin diseases. The purpose of the study is to evaluate the antiulcer, antidiabetic enzymatic inhibition, antibacterial and antioxidant actions of different polarity extracts of fruits of Myrtus communis L. Materials and Methods: Methanol (crude extract) and its fractions (n-hexane (MCFH), dichloromethane (MCFD), ethyl acetate (MCFE), butanol (MCFB) and aqueous (MCFA)) from fruits of Myrtus communis L. were produced and assessed for their antimicrobial, antioxidant, α-glucosidase and antiulcer in vitro bioassays. All of the fractions were tested using a brine shrimp lethality assay to determine their cytotoxic effects. Results: The examined samples demonstrated a sizable capacity to fend off the gram-negative and gram-positive bacteria. The MCFB determined the best antibacterial activity of the five extracts, with an average inhibitions zone of 9.3 mm against Staphylococcus aureus and 6.75 mm against Escherichia coli. The MCFA extract displayed the second-highest antibacterial activity against Pseudomonas aeruginosa, with an average inhibition zone of 9.5 mm, while MCFH had the least amount of activity against the bacteria that were tested. In the anti-alpha glucosidase activity, MCFE was the best with IC 50 of 20.04±0.38 µg mLG 1 and the unease inhibition was best seen with the MCFA and MCFB extracts with IC 50 values of 146.87±1.39 and 194.97±1.68 µg mLG 1 , respectively. All extracts showed no significant cytotoxic activity. Conclusion: Therefore, all tested samples, especially MCFE and MCFB extracts, were assumed to have significant capacities for the studied activities.

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Effect of Ricinodendron heudelotii seed extract on the oxidative stress biomarkers of Diabetic albino rats

Cited by 4 publications

References 12 publications

Male Reproductive Hormonal Activity of Synergistic Ingestion of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera in Male Rat Model

Male Reproductive Hormonal Activity of Synergistic Ingestion of Aqueous Extract of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera in Male Rat Model

Evaluation of Tumor necrosis factor (TNF-α) Concertation and Renal function in the Sera of patients with Type 2 diabetes in Erbil city

Pharmacology and Enzyme Inhibitory Potentials of Myrtus communis L. Fruits Grown in Oman

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