Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Tao, Lixin; Yang, Kun; Wu, Jie; Mahara, Gehendra; Zhang, Jie; Zhang, Jingbo; Zhao, Ping; Guo, Xiuhua

doi:10.1111/jch.13398

Cited by 14 publications

(12 citation statements)

References 49 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2017, a meta-analysis incorporating 15 studies worldwide also showed the positive causal relationship might be confounded by several factors ( 26 ). However, in 2018 Tao et al ( 8 ) described the gender-specific causal relationship based on a sample of 3,913 participants from a longitudinal cohort in Chinese population. Other studies from China also demonstrated positive relationship between Hcy level and hypertension ( 27 – 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the relationship could be greatly influenced by multiple factors such as race, gender, age, and nutritional supplementation ( 7 ). Recently, a large longitudinal study done by Tao et al ( 8 ) proved that serum Hcy level predicts hypertension. With a high prevalence of hypertension ( 9 ) and HHcy ( 7 ), Hcy might play a more important role in Chinese population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study

Ren

Zhang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Introduction: Serum homocysteine (Hcy) level is associated with cardiocerebrovascular disease. However, the relationship between Hcy and hypertension-mediated organ damage (HMOD) in non-hospitalized residents has not been elucidated. We aimed to investigate the association of HMOD with Hcy in elderly Chinese.Methods: One thousand seven hundred and forty-four community-dwelling elderly Chinese (age ≥65 years) participated in the Northern Shanghai Study from Jun. 2014 to Aug. 2015. Hyperhomocysteinemia (HHcy) was defined as serum Hcy ≥15 mmol/L, and HMOD was estimated as arterial stiffness [carotid-femoral pulse wave velocity (CF-PWV) and ankle-brachial index (ABI)], cardiac impairment [left ventricular (LV) hypertrophy and LV diastolic dysfunction], and renal dysfunction [estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio]. Linear and logistic regression models were built to explore the associations of HMOD with Hcy.Results: Among 1,744 participants, 632 (36.2%) were diagnosed as HHcy. HHcy group had more men (61.2 vs. 35.3%), with higher age (73.7 ± 6.7 vs. 70.4 ± 5.3 years) and BMI (24.2 ± 3.4 vs. 23.7 ± 3.5 kg/m2). Linear regression analysis showed that serum Hcy level was positively associated CF-PWV and negatively associated with ABI and eGFR. By logistic regression, HHcy was significantly associated with abnormal CF-PWV [odds ratio (OR) = 1.53, 95% confidence interval (CI) 1.08–2.16] and ABI (OR = 1.55, 95% CI 1.17–2.04), and decreased eGFR (OR = 7.09, 95% CI 4.03–12.47) after adjustment for covariates. Moreover, similar associations of serum Hcy level with CF-PWV and eGFR were observed in subgroups by gender and hypertensive state.Conclusion: HMOD, particularly renal dysfunction and arterial stiffening, was significantly and independently associated with increased serum Hcy level in the elderly Chinese.Clinical Trial Registration: [ClinicalTrial.gov], identifier [NCT02368938].

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study

Ren

Zhang

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…In patients with high cholesterol levels, the administration of folic acid reduced the risk of stroke by 30% [67]. In recent years several large meta-analyses have been published, all of which stated that folic acid therapy and possibly with the addition of other B vitamins reduces the risk of stroke by 10%-15% [56,68,69]. A meta-analysis by Wanga et al assessed the efficacy of folic acid supplementation among patients with hypertension and hyperhomocysteinemia (homocysteine >10 µmol/l) [56].…”

Section: Administration Of Folic Acid In the Preventions Of Strokesmentioning

confidence: 99%

The significance of homocysteine in patients with hypertension

Głuszek¹,

Kosicka

2021

Postępy Higieny I Medycyny Doświadczalnej

View full text Add to dashboard Cite

Cardiovascular disease is the most common cause of death in developed countries. Important factors leading to ischemic heart disease and strokes are hypertension and high levels of homocysteine in blood serum. The coexistence of these two factors significantly increases the risk of these diseases and premature deaths. Many studies indicate that patients with hypertension are significantly more likely to demonstrate increased blood serum homocysteine levels than those with normal blood pressure. This may be caused by a higher incidence of overweight, high intake of salt and increased uric acid levels. It has been shown that both these factors increase the prevalence of hypertension and lead to higher homocysteine levels. However, the results of some studies indicate that arterial hypertension and homocysteinemia are causally related. It was shown, among other things, that high homocysteine levels damage the endothelium and reduce nitric oxide synthesis, which may directly lead to hypertension. Serum homocysteine levels are slightly higher in patients with white coat hypertension than they are in healthy individuals and may therefore also increase the risk of cardiovascular diseases. Several authors have also shown that the levels of homocysteine in blood serum are higher in so-called non-dippers, i.e., patients with no night-time pressure drop. The lack of a 10%–20% decrease in blood pressure at night is associated with increased cardiovascular complications. Strokes occur especially frequently in older people with arterial hypertension and hyperhomocysteinemia. The administration of B vitamins and folic acid significantly reduces serum homocysteine levels. The administration of this acid also slightly, but statistically significantly, increases the effectiveness of hypotensive drugs. Large meta-analyses meta-analysis indicate that the increased supply of folic acid in patients with hypertension significantly reduces the risk of stroke. Such management is particularly effective in patients with hypertension and hyperhomocysteinemia.

show abstract

“…К "сосудистым" ФР МАГ относят и избыточную прокоагулянтную активность крови, нередко ассоциированную с НВ. Показано, в частности, что при повышенном АД сосудисто-тромбоцитарное звено гемостаза характеризуется усилением спонтанной и индуцированной агрегационной способности тромбоцитов, возрастанием активности фактора Виллебранда, что было особенно заметным на фоне увеличенной концентрации в крови гомоцистеина [37]. У больных МАГ средние значения последнего индикатора обычно ниже, чем при стабильной АГ, а показатели гемостаза характеризуются увеличением концентрации в крови фибриногена, тромбомодулина, ингибитора активатора плазминогена, активатора тканевого плазминогена.…”

Section: факторы риска и патофизиологические детерминанты магunclassified

Masked arterial hypertension: prevalence, pathophysiological determinants and clinical significance

et al. 2019

View full text Add to dashboard Cite

In most modern studies, masked arterial hypertension (MAH) is characterized as a poorly diagnosed, latent clinical condition predisposing to subclinical damage to target organs and an increased risk of cardiovascular complications. The prevalence of MAH among the population depends on gender, age, anthropometric and socioeconomic factors, profession, race and other characteristics. The most important risk factors (RF) of MAH and its pathophysiological determinants include genetic polymorphism, subclinical non-specific inflammation, hemostatic disorders, obesity, metabolic syndrome, water-salt imbalance, dyslipidemia, hyperuricemia. A defined value has latent dysfunction of the mechanisms that provide circulatory homeostasis, the detection of which is possible by the hemodynamic response to psycho-emotional, hypoxic, hypocapnic, orthostatic effects. Aggressiveness of RF exposure and the consequences of their implementation are evaluated by the rate of development of cardiovascular events and mortality, which indicate an unfavorable prognosis of “uncontrolled” MAH. The maximum reduction of the RF effects and rational pharmacotherapy can significantly improve its clinical prospects.

show abstract

Association between plasma homocysteine and hypertension: Results from a cross‐sectional and longitudinal analysis in Beijing’s adult population from 2012 to 2017

Cited by 14 publications

References 49 publications

Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study

Hypertension-Mediated Organ Damage Correlates With Serum Homocysteine Level in Community-Dwelling Elderly Chinese: The North Shanghai Study

The significance of homocysteine in patients with hypertension

Masked arterial hypertension: prevalence, pathophysiological determinants and clinical significance

Contact Info

Product

Resources

About