Association between plasma endothelial microparticles and contrast-induced nephropathy in patients underwent coronary angiography

Abstract

We aim to investigate the association between plasma endothelial microparticles (EMPs) and contrast-induced nephropathy of patients underwent coronary angiography. The patients were divided into normal renal function group and renal dysfunction group based on the estimated glomerular filtration rate (eGFR). Among the 180 cases, 117 received determination of EMP and serum creatinine after percutaneous coronary intervention (PCI) and/or coronary angiography. The patients were divided into contrast-induced-nephropathy (CIN) group and non-CIN group. EMPs collection and determination were performed, together with biochemical analysis and digital subtraction angiography (DSA) analysis. Spearman correlation showed that the expression of EMP was negatively correlated with eGFR ( r = –0.201, P < .01). The serum hypersensitive C-reactive protein (hs-CRP), cystatin C (Cys-C), uric acid (UA) were significantly higher in CIN group than that in the non CIN group. Spearman correlation showed that the expression of EMP was positively correlated with serum interleukin-6 (IL-6, r = 0.393, P < .01). The expression of EMP was positively correlated with serum hs-CRP ( r = 0.360, P < .01). Logistic regression analysis showed that the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), eGFR, UA, and Cys-C were correlated with the incidence of contrast induced nephropathy. In patients with contrast-induced-nephropathy, the plasma EMPs were significantly increased after coronary angiography. The expression of plasma EMPs may play a role in the occurrence of contrast-induced-nephropathy.

C-Reactive Protein/Albumin Ratio as a Novel Predictor of Contrast Induced Nephropathy in Patients With Stable Angina Pectoris

“…7,10,[18][19][20] A recent study, which investigated the relationship between plasma endothelial microparticles and CIN in patients who underwent CAG, demonstrated that cystatin-C, high-sensitivity CRP, and uric acid were significantly higher in patients with CIN than ones without CIN. 8 The researchers found that elevated microparticles in CIN patients correlated with interleukin-6 and high-sensitivity CRP, and reported that high cystatin-C, uric acid, and N-terminal pro-brain natriuretic peptide were the predictors of CIN rather than high-sensitivity CRP. 8 Another study reported that the combination of procalcitonin and highsensitivity CRP was a better predictor of CIN than either procalcitonin or high-sensitivity CRP alone in patients underwent PCI.…”

“…8 The researchers found that elevated microparticles in CIN patients correlated with interleukin-6 and high-sensitivity CRP, and reported that high cystatin-C, uric acid, and N-terminal pro-brain natriuretic peptide were the predictors of CIN rather than high-sensitivity CRP. 8 Another study reported that the combination of procalcitonin and high-sensitivity CRP was a better predictor of CIN than either procalcitonin or high-sensitivity CRP alone in patients underwent PCI. 7 Thus, many markers of inflammation, other than CRP, have been recently investigated and some of them are superior to CRP.…”

“…4,6 Studies reported the relation of inflammation markers including the C-reactive protein (CRP), high sensitivity-CRP, procalcitonin, cystatin-C, uric acid, the neutrophil to lymphocyte ratio (NLR), the platelet to lymphocyte ratio (PLR), red cell distribution width (RDW), and hematocrit with the development of CIN. [7][8][9][10] Recent studies have reported the importance of the CRP to albumin ratio (CAR) in some clinical conditions, and that CAR can be a useful indicator of coronary artery disease severity. [11][12][13][14] It has been reported that CAR is an important predictor of CIN development in patients with myocardial infarction.…”

Relationship Between Prognostic Nutritional Index and Contrast-Associated Acute Kidney Injury in Patients With Non-ST Segment Elevation Myocardial Infarction Undergoing Coronary Angiography

“…The relationship between the CRP values and the increased risk of CA-AKI development has been reported. 38,39 In a study involving 2133 patients admitted to a CAG laboratory, hsCRP levels were found to predict the risk for developing CA-AKI at a level similar to the MRS scores. 38 Endothelial dysfunction and oxidative stress play a prominent role in the development of contrast-induced nephropathy, whereas inflammation plays a central role.…”