Association between physical activity and dementia’s risk factors in patients with Parkinson’s disease

Alwardat, Mohammad; Schirinzi, Tommaso; Lazzaro, Giulia Di; Sancesario, Giulia Maria; Franco, Donatella; Imbriani, Paola; Salimei, Paola Sinibaldi; Bernardini, Sergio; Mercuri, Nicola Biagio; Pisani, Antonio

doi:10.1007/s00702-019-01979-0

Cited by 30 publications

(20 citation statements)

References 43 publications

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“…A previous study, assessing through traditional enrolment into a clinic setting the relationship between physical exercise and dementia risk factors, showed in PD patients a METs level of 1443 ± 2197.5 min/week 8 . Although proper comparisons with this previous group are not reliable, the relatively higher METs amount that we found here (1994.7 ± 1971 min/week) suggests some peculiarity in the present cohort, probably due to different educational level or clinical severity.…”

Section: Discussioncontrasting

confidence: 55%

“…Although the reasons of such decline could not be directly determined, we observed that the main identified risk factor associated with perceived worsening was the low total MET score. MET is an index of energy expenditure that results from IPAQ‐SF, a commonly used questionnaire to assess quantitatively physical activity, even in PD 8,10 . A higher rate of physical activity improves quality of life, mood, and cognitive performances, and even motor disturbances in PD patients, exerting beneficial effects either at brain or systemic level 8,11,12 .…”

Section: Discussionmentioning

confidence: 99%

“…MET is an index of energy expenditure that results from IPAQ‐SF, a commonly used questionnaire to assess quantitatively physical activity, even in PD 8,10 . A higher rate of physical activity improves quality of life, mood, and cognitive performances, and even motor disturbances in PD patients, exerting beneficial effects either at brain or systemic level 8,11,12 . The reduction of such “protective” action might thus explain the perception of worsening in these patients, which also presented a greater burden of PD‐related disturbances (PWBM score) and depressive symptoms (BDI score) compared to those referring stable conditions.…”

Section: Discussionmentioning

confidence: 99%

“…A structured questionnaire was set up to collect data on demographics including age at PD onset and disease duration; motor activity habits before COVID‐19 emergency: physiotherapy/rehabilitation practice, sports practice (type and weekly frequency); motor activity habits during lockdown: physiotherapy/rehabilitation practice, physical exercise practice (indoor/outdoor, type of activity); use of TBTs (specifically free web video lessons, web video course organized by institutions/associations, video games, and smartphone applications), previous experience, frequency of current use, opinion on the usefulness; use of wearable devices (eg pedometer); perception of own health during COVID‐19 emergency (specifically, we asked: “Do you feel that your global health was worsened or remained stable during the lockdown?”). Three self‐administered scales were also included in the survey: the International Physical Activity Questionnaires‐Short Form (IPAQ–SF), 7,8 a self‐reported questionnaire to quantify the intensity of physical activity as metabolic equivalent (MET) min/week; the Parkinson's Well‐Being Map (PWBM), a self‐reported score of motor and non‐motor symptoms divided into 8 items 9 to assess clinical severity; and the Beck Depression Index (BDI) to estimate depression. All responses were transformed in categorical or continuous variables as appropriate for statistical analysis.…”

Section: Methodsmentioning

confidence: 99%

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Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

Schirinzi

Lazzaro

Salimei

et al. 2020

Movement Disord Clin Pract

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Background Background: COVID-19 outbreak profoundly affected health systems and people's daily life worldwide. Parkinson's disease (PD) patients lost their normal routine and interrupted regular physical activity, either as physiotherapy or sport, with inevitable consequence on their daily-life and well-being. Objectives Objectives: To evaluate the changes in physical activity due to COVID-19 emergency, including self-management strategies or technology-assisted activities, and the subsequent clinical implications in PD patients. Methods Methods: Seventy-four patients from an Italian center have been remotely examined during the lockdown (April-May 2020) by an e-mail structured survey, including self-administered scales. We collected and analyzed data on changes, modalities and amount of physical active practice, on the use of technology-based tools, and on self-perceived clinical condition. Results Results: Sixty percent of patients reported a significant worsening of their general conditions during the lockdown, the reduction of physical activity being the main risk factor for such change. However, patients found ways to practice physical activity, using satisfactorily technology assistance in 50% of cases (mostly women). Conclusions Conclusions: The COVID-19 emergency has been an ordeal for PD patients. Nevertheless, patients adapted their habits to continue practicing physical activity that resulted a main determinant of their well-being; as well, they successfully approached technology-based assistance. Education, communication, and networking emerge as critical for a constructive reaction to the emergency's challenges.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Physical Activity Changes and Correlate Effects in Patients with Parkinson's Disease during COVID‐19 Lockdown

Schirinzi

Lazzaro

Salimei

et al. 2020

Movement Disord Clin Pract

Self Cite

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“…Parkinson's Disease [39][40][41][42]. There is no strong supporting evidence for the hypothesis that physical activity can prevent male PD in the Harvard Alumni Health Study.…”

Section: Physical Activity Prevention Andmentioning

confidence: 99%

What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Fan

Jabeen

et al. 2020

Oxidative Medicine and Cellular Longevity

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Aim. This study was aimed at investigating the effects and molecular mechanisms of physical activity intervention on Parkinson’s disease (PD) and providing theoretical guidance for the prevention and treatment of PD. Methods. Four electronic databases up to December 2019 were searched (PubMed, Springer, Elsevier, and Wiley database), 176 articles were selected. Literature data were analyzed by the logic analysis method. Results. (1) Risk factors of PD include dairy products, pesticides, traumatic brain injury, and obesity. Protective factors include alcohol, tobacco, coffee, black tea, and physical activity. (2) Physical activity can reduce the risk and improve symptoms of PD and the beneficial forms of physical activity, including running, dancing, traditional Chinese martial arts, yoga, and weight training. (3) Different forms of physical activity alleviate the symptoms of PD through different mechanisms, including reducing the accumulation of α-syn protein, inflammation, and oxidative stress, while enhancing BDNF activity, nerve regeneration, and mitochondrial function. Conclusion. Physical activity has a positive impact on the prevention and treatment of PD. Illustrating the molecular mechanism of physical activity-induced protective effect on PD is an urgent need for improving the efficacy of PD therapy regimens in the future.

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